Synthesis, structural characterization and effect on human granulocyte intracellular cAMP levels of abscisic acid analogs

[Display omitted] The phytohormone abscisic acid (ABA), in addition to regulating physiological functions in plants, is also produced and released by several mammalian cell types, including human granulocytes, where it stimulates innate immune functions via an increase of the intracellular cAMP conc...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2015-01, Vol.23 (1), p.22-32
Hauptverfasser:	Bellotti, Marta, Salis, Annalisa, Grozio, Alessia, Damonte, Gianluca, Vigliarolo, Tiziana, Galatini, Andrea, Zocchi, Elena, Benatti, Umberto, Millo, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscisic acid Abscisic Acid - analogs & derivatives Abscisic Acid - chemical synthesis Abscisic Acid - chemistry Abscisic Acid - pharmacology Abscisic acid analogs cAMP Cyclic AMP - metabolism Granulocytes Granulocytes - drug effects Granulocytes - metabolism Humans Inflammatory disease Intracellular Membranes - drug effects Signal Transduction Structure-Activity Relationship
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