The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine
Stem cells with multipotent and self-renewal abilities play a vital role in regenerative medicine and tissue engineering. They can assist tissue reconstruction through specific differentiation and secretion of various bioactive macromolecules. More and more studies confirm that the cell-fate commitm...
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| Veröffentlicht in: | Materials Science & Engineering C 2014-12, Vol.45, p.671-681 |
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| container_title | Materials Science & Engineering C |
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| creator | Jin, Guorui Li, Kai |
| description | Stem cells with multipotent and self-renewal abilities play a vital role in regenerative medicine and tissue engineering. They can assist tissue reconstruction through specific differentiation and secretion of various bioactive macromolecules. More and more studies confirm that the cell-fate commitment can be manipulated via constructing a specific stem cell niche. The construction of specific niches with conductive materials (conducting polymers, carbon nanotubes and graphene) can promote stem cell differentiation towards electro-active lineages and emphasize the promising role of stem cells in electro-active tissue regeneration (e.g., nerve and heart). In this review, we summarize the commonly applied conductive materials for scaffold construction and evaluate their contributions in the regeneration of electro-active tissues.
•Stem cell, niche and their contributions in regenerative medicine are summarized.•Fabrication and cytotoxicity of commonly used conductive materials are reviewed.•Conductive scaffolds for guiding stem cell differentiation are well discussed. |
| doi_str_mv | 10.1016/j.msec.2014.06.004 |
| format | Article |
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•Stem cell, niche and their contributions in regenerative medicine are summarized.•Fabrication and cytotoxicity of commonly used conductive materials are reviewed.•Conductive scaffolds for guiding stem cell differentiation are well discussed.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2014.06.004</identifier><identifier>PMID: 25491876</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Conductive scaffold ; Construction materials ; Construction specifications ; Differentiation ; Electric Conductivity ; Graphite - chemistry ; Humans ; Medicine ; Nanotubes, Carbon - chemistry ; Polymers - chemistry ; Regeneration ; Regenerative ; Regenerative Medicine ; Scaffolds ; Stem Cell Niche ; Stem cells ; Stem Cells - cytology ; Tissue Engineering ; Tissue Scaffolds</subject><ispartof>Materials Science & Engineering C, 2014-12, Vol.45, p.671-681</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c632t-75776634b752f3623abeea19943ba10db8ee8c0524720a0e73f8cd2117a28f963</citedby><cites>FETCH-LOGICAL-c632t-75776634b752f3623abeea19943ba10db8ee8c0524720a0e73f8cd2117a28f963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2014.06.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25491876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Guorui</creatorcontrib><creatorcontrib>Li, Kai</creatorcontrib><title>The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Stem cells with multipotent and self-renewal abilities play a vital role in regenerative medicine and tissue engineering. They can assist tissue reconstruction through specific differentiation and secretion of various bioactive macromolecules. More and more studies confirm that the cell-fate commitment can be manipulated via constructing a specific stem cell niche. The construction of specific niches with conductive materials (conducting polymers, carbon nanotubes and graphene) can promote stem cell differentiation towards electro-active lineages and emphasize the promising role of stem cells in electro-active tissue regeneration (e.g., nerve and heart). In this review, we summarize the commonly applied conductive materials for scaffold construction and evaluate their contributions in the regeneration of electro-active tissues.
•Stem cell, niche and their contributions in regenerative medicine are summarized.•Fabrication and cytotoxicity of commonly used conductive materials are reviewed.•Conductive scaffolds for guiding stem cell differentiation are well discussed.</description><subject>Conductive scaffold</subject><subject>Construction materials</subject><subject>Construction specifications</subject><subject>Differentiation</subject><subject>Electric Conductivity</subject><subject>Graphite - chemistry</subject><subject>Humans</subject><subject>Medicine</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Polymers - chemistry</subject><subject>Regeneration</subject><subject>Regenerative</subject><subject>Regenerative Medicine</subject><subject>Scaffolds</subject><subject>Stem Cell Niche</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkTtPwzAUhS0EoqXwBxiQR5aEazuxE4kFIV5SJZYyG8e5AZc8ip0i9d_jUmBETB7ud46s8xFyyiBlwOTFMu0C2pQDy1KQKUC2R6asUCIBVrJ9MoWSF0lWCjYhRyEsAWQhFD8kE55nZQTllDwvXpFii3b0zpq23VA79PXaju4DabCmaYa2pibQMXLhLZLj0NOhoWHEjlpsW9o7G2-upx5fsEdvvrId1s66Ho_JQWPagCff74w83d4sru-T-ePdw_XVPLFS8DFRuVJSiqxSOW-E5MJUiIaVZSYqw6CuCsTCQs4zxcEAKtEUtuaMKcOLppRiRs53vSs_vK8xjLpzYfs_0-OwDppJCVDmuVD_QEUOIIo8iyjfodYPIXhs9Mq7zviNZqC3EvRSbyXorQQNUkcJMXT23b-u4gy_kZ_VI3C5AzAO8uHQ62Ad9jZO5qMJXQ_ur_5PrXOX7A</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Jin, Guorui</creator><creator>Li, Kai</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20141201</creationdate><title>The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine</title><author>Jin, Guorui ; Li, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c632t-75776634b752f3623abeea19943ba10db8ee8c0524720a0e73f8cd2117a28f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Conductive scaffold</topic><topic>Construction materials</topic><topic>Construction specifications</topic><topic>Differentiation</topic><topic>Electric Conductivity</topic><topic>Graphite - chemistry</topic><topic>Humans</topic><topic>Medicine</topic><topic>Nanotubes, Carbon - chemistry</topic><topic>Polymers - chemistry</topic><topic>Regeneration</topic><topic>Regenerative</topic><topic>Regenerative Medicine</topic><topic>Scaffolds</topic><topic>Stem Cell Niche</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds</topic><toplevel>online_resources</toplevel><creatorcontrib>Jin, Guorui</creatorcontrib><creatorcontrib>Li, Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Guorui</au><au>Li, Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>45</volume><spage>671</spage><epage>681</epage><pages>671-681</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Stem cells with multipotent and self-renewal abilities play a vital role in regenerative medicine and tissue engineering. 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| fulltext | fulltext |
| identifier | ISSN: 0928-4931 |
| ispartof | Materials Science & Engineering C, 2014-12, Vol.45, p.671-681 |
| issn | 0928-4931 1873-0191 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Conductive scaffold Construction materials Construction specifications Differentiation Electric Conductivity Graphite - chemistry Humans Medicine Nanotubes, Carbon - chemistry Polymers - chemistry Regeneration Regenerative Regenerative Medicine Scaffolds Stem Cell Niche Stem cells Stem Cells - cytology Tissue Engineering Tissue Scaffolds |
| title | The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine |
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