Pesticide exposure and screen-positive neuropsychiatric disease in British sheep farmers
Epidemiological evidence linking low dose pesticide exposure and chronic ill-health in UK sheep farmers is limited. Our aim was to examine whether neuropsychiatric disorders were associated with low dose chronic and/or more acute pesticide exposure in sheep farmers. A cohort of British farmers worki...
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| Veröffentlicht in: | Environmental research 2014-11, Vol.135, p.262-270 |
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| creator | Povey, Andrew C. McNamee, Roseanne Alhamwi, Haytham Stocks, S. Jill Watkins, Gillian Burns, Alistair Agius, Raymond |
| description | Epidemiological evidence linking low dose pesticide exposure and chronic ill-health in UK sheep farmers is limited. Our aim was to examine whether neuropsychiatric disorders were associated with low dose chronic and/or more acute pesticide exposure in sheep farmers.
A cohort of British farmers working in the 1970s was sent a screening questionnaire which asked about their health and work history. The prevalence of screen-positive depression, dementia, Parkinsonism and neuropathy was determined using a priori algorithms. Self-reported pesticide exposure was assessed by whether the participant had ever handled the pesticide concentrate (for low dose chronic exposure) or sought advice for pesticide poisoning (acute exposure) and participants categorised into those with only acute or chronic exposure, those with both acute and chronic exposure and those with neither acute nor chronic exposure. Associations between acute and chronic pesticide exposure, and screen-positive ill-health were determined after adjustment for demographic, lifestyle, occupation and somatic severity scores and other variables.
In those participants, who had never sought advice for pesticide poisoning, handling the pesticide concentrate for treating sheep was associated with elevated ORs for screen-positive neuropathy (ORadi 1.57 95%CI 0.97–2.54) and Parkinsonism (ORadj 1.56 95%CI 0.95–2.56) but not depression or dementia. In those participants who had handled the pesticide concentrate, seeking advice for pesticide poisoning was associated with screen-positive depression (Odds ratio, ORadj=9.97 95%CI 4.76–20.8 ), dementia (OR=6.94 95%CI 3.44–14.0), Parkinsonism (ORadj=4.77 95% 2.39–9.52), and neuropathy (ORadj=4.77 95%CI 2.39–9.52). Adjustment for somatic severity score modified little the associations with pesticide handling in those not acutely exposed but reduced the ORs for seeking advice for pesticide poisoning in those exposed chronically. Furthermore, stratification of results based upon somatic severity score indicated that the highest ORs for handling the pesticide concentrate associated with neuropathy and Parkinsonism were found in those participants whose somatic score was minimal.
Results are consistent with low-dose exposure to pesticides being associated with screen-positive neuropathy and Parkinsonism but the stronger associations between seeking advice for pesticide poisoning and screen-positive ill-health suggest that acute pesticide exposure remains an important determ |
| doi_str_mv | 10.1016/j.envres.2014.09.008 |
| format | Article |
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A cohort of British farmers working in the 1970s was sent a screening questionnaire which asked about their health and work history. The prevalence of screen-positive depression, dementia, Parkinsonism and neuropathy was determined using a priori algorithms. Self-reported pesticide exposure was assessed by whether the participant had ever handled the pesticide concentrate (for low dose chronic exposure) or sought advice for pesticide poisoning (acute exposure) and participants categorised into those with only acute or chronic exposure, those with both acute and chronic exposure and those with neither acute nor chronic exposure. Associations between acute and chronic pesticide exposure, and screen-positive ill-health were determined after adjustment for demographic, lifestyle, occupation and somatic severity scores and other variables.
In those participants, who had never sought advice for pesticide poisoning, handling the pesticide concentrate for treating sheep was associated with elevated ORs for screen-positive neuropathy (ORadi 1.57 95%CI 0.97–2.54) and Parkinsonism (ORadj 1.56 95%CI 0.95–2.56) but not depression or dementia. In those participants who had handled the pesticide concentrate, seeking advice for pesticide poisoning was associated with screen-positive depression (Odds ratio, ORadj=9.97 95%CI 4.76–20.8 ), dementia (OR=6.94 95%CI 3.44–14.0), Parkinsonism (ORadj=4.77 95% 2.39–9.52), and neuropathy (ORadj=4.77 95%CI 2.39–9.52). Adjustment for somatic severity score modified little the associations with pesticide handling in those not acutely exposed but reduced the ORs for seeking advice for pesticide poisoning in those exposed chronically. Furthermore, stratification of results based upon somatic severity score indicated that the highest ORs for handling the pesticide concentrate associated with neuropathy and Parkinsonism were found in those participants whose somatic score was minimal.
Results are consistent with low-dose exposure to pesticides being associated with screen-positive neuropathy and Parkinsonism but the stronger associations between seeking advice for pesticide poisoning and screen-positive ill-health suggest that acute pesticide exposure remains an important determinant of ill-health. Further work is required to better delineate to what extent low dose exposures may contribute to ill-health in populations without acute exposures. Somatising tendency does not appear to play an important role in this population.
•We investigated health effects of pesticide exposure in UK farmers.•Ill-health was associated with both acute and chronic low dose pesticide exposure.•Somatising tendency was associated with ill-health but was not found to be an important confounder.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2014.09.008</identifier><identifier>PMID: 25462674</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Agriculture - statistics & numerical data ; Animals ; Biological and medical sciences ; Brain Diseases - chemically induced ; Brain Diseases - epidemiology ; Cohort Studies ; Cross-Sectional Studies ; Depression ; Exposure ; Farming ; Handling ; Humans ; Logistic Models ; Medical sciences ; Mental Disorders - chemically induced ; Mental Disorders - epidemiology ; Neuropsychiatric ill-health ; Occupational Exposure - adverse effects ; Occupational medicine ; Odds Ratio ; Organophosphates ; Pesticides ; Pesticides - adverse effects ; Pesticides, fertilizers and other agrochemicals toxicology ; Poisoning ; Populations ; Prevalence ; Public health. Hygiene-occupational medicine ; Sheep ; Surveys and Questionnaires ; Toxicology ; United Kingdom - epidemiology</subject><ispartof>Environmental research, 2014-11, Vol.135, p.262-270</ispartof><rights>2014</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-eef85b0aba741b1160b884b31ac8dae85a2057b208ab2570b83e6a4e56f0ede83</citedby><cites>FETCH-LOGICAL-c458t-eef85b0aba741b1160b884b31ac8dae85a2057b208ab2570b83e6a4e56f0ede83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0013935114003119$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29075660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25462674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Povey, Andrew C.</creatorcontrib><creatorcontrib>McNamee, Roseanne</creatorcontrib><creatorcontrib>Alhamwi, Haytham</creatorcontrib><creatorcontrib>Stocks, S. Jill</creatorcontrib><creatorcontrib>Watkins, Gillian</creatorcontrib><creatorcontrib>Burns, Alistair</creatorcontrib><creatorcontrib>Agius, Raymond</creatorcontrib><title>Pesticide exposure and screen-positive neuropsychiatric disease in British sheep farmers</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Epidemiological evidence linking low dose pesticide exposure and chronic ill-health in UK sheep farmers is limited. Our aim was to examine whether neuropsychiatric disorders were associated with low dose chronic and/or more acute pesticide exposure in sheep farmers.
A cohort of British farmers working in the 1970s was sent a screening questionnaire which asked about their health and work history. The prevalence of screen-positive depression, dementia, Parkinsonism and neuropathy was determined using a priori algorithms. Self-reported pesticide exposure was assessed by whether the participant had ever handled the pesticide concentrate (for low dose chronic exposure) or sought advice for pesticide poisoning (acute exposure) and participants categorised into those with only acute or chronic exposure, those with both acute and chronic exposure and those with neither acute nor chronic exposure. Associations between acute and chronic pesticide exposure, and screen-positive ill-health were determined after adjustment for demographic, lifestyle, occupation and somatic severity scores and other variables.
In those participants, who had never sought advice for pesticide poisoning, handling the pesticide concentrate for treating sheep was associated with elevated ORs for screen-positive neuropathy (ORadi 1.57 95%CI 0.97–2.54) and Parkinsonism (ORadj 1.56 95%CI 0.95–2.56) but not depression or dementia. In those participants who had handled the pesticide concentrate, seeking advice for pesticide poisoning was associated with screen-positive depression (Odds ratio, ORadj=9.97 95%CI 4.76–20.8 ), dementia (OR=6.94 95%CI 3.44–14.0), Parkinsonism (ORadj=4.77 95% 2.39–9.52), and neuropathy (ORadj=4.77 95%CI 2.39–9.52). Adjustment for somatic severity score modified little the associations with pesticide handling in those not acutely exposed but reduced the ORs for seeking advice for pesticide poisoning in those exposed chronically. Furthermore, stratification of results based upon somatic severity score indicated that the highest ORs for handling the pesticide concentrate associated with neuropathy and Parkinsonism were found in those participants whose somatic score was minimal.
Results are consistent with low-dose exposure to pesticides being associated with screen-positive neuropathy and Parkinsonism but the stronger associations between seeking advice for pesticide poisoning and screen-positive ill-health suggest that acute pesticide exposure remains an important determinant of ill-health. Further work is required to better delineate to what extent low dose exposures may contribute to ill-health in populations without acute exposures. Somatising tendency does not appear to play an important role in this population.
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Hygiene-occupational medicine</topic><topic>Sheep</topic><topic>Surveys and Questionnaires</topic><topic>Toxicology</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Povey, Andrew C.</creatorcontrib><creatorcontrib>McNamee, Roseanne</creatorcontrib><creatorcontrib>Alhamwi, Haytham</creatorcontrib><creatorcontrib>Stocks, S. 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Jill</au><au>Watkins, Gillian</au><au>Burns, Alistair</au><au>Agius, Raymond</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pesticide exposure and screen-positive neuropsychiatric disease in British sheep farmers</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>135</volume><spage>262</spage><epage>270</epage><pages>262-270</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>Epidemiological evidence linking low dose pesticide exposure and chronic ill-health in UK sheep farmers is limited. Our aim was to examine whether neuropsychiatric disorders were associated with low dose chronic and/or more acute pesticide exposure in sheep farmers.
A cohort of British farmers working in the 1970s was sent a screening questionnaire which asked about their health and work history. The prevalence of screen-positive depression, dementia, Parkinsonism and neuropathy was determined using a priori algorithms. Self-reported pesticide exposure was assessed by whether the participant had ever handled the pesticide concentrate (for low dose chronic exposure) or sought advice for pesticide poisoning (acute exposure) and participants categorised into those with only acute or chronic exposure, those with both acute and chronic exposure and those with neither acute nor chronic exposure. Associations between acute and chronic pesticide exposure, and screen-positive ill-health were determined after adjustment for demographic, lifestyle, occupation and somatic severity scores and other variables.
In those participants, who had never sought advice for pesticide poisoning, handling the pesticide concentrate for treating sheep was associated with elevated ORs for screen-positive neuropathy (ORadi 1.57 95%CI 0.97–2.54) and Parkinsonism (ORadj 1.56 95%CI 0.95–2.56) but not depression or dementia. In those participants who had handled the pesticide concentrate, seeking advice for pesticide poisoning was associated with screen-positive depression (Odds ratio, ORadj=9.97 95%CI 4.76–20.8 ), dementia (OR=6.94 95%CI 3.44–14.0), Parkinsonism (ORadj=4.77 95% 2.39–9.52), and neuropathy (ORadj=4.77 95%CI 2.39–9.52). Adjustment for somatic severity score modified little the associations with pesticide handling in those not acutely exposed but reduced the ORs for seeking advice for pesticide poisoning in those exposed chronically. Furthermore, stratification of results based upon somatic severity score indicated that the highest ORs for handling the pesticide concentrate associated with neuropathy and Parkinsonism were found in those participants whose somatic score was minimal.
Results are consistent with low-dose exposure to pesticides being associated with screen-positive neuropathy and Parkinsonism but the stronger associations between seeking advice for pesticide poisoning and screen-positive ill-health suggest that acute pesticide exposure remains an important determinant of ill-health. Further work is required to better delineate to what extent low dose exposures may contribute to ill-health in populations without acute exposures. Somatising tendency does not appear to play an important role in this population.
•We investigated health effects of pesticide exposure in UK farmers.•Ill-health was associated with both acute and chronic low dose pesticide exposure.•Somatising tendency was associated with ill-health but was not found to be an important confounder.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>25462674</pmid><doi>10.1016/j.envres.2014.09.008</doi><tpages>9</tpages></addata></record> |
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| subjects | Agriculture - statistics & numerical data Animals Biological and medical sciences Brain Diseases - chemically induced Brain Diseases - epidemiology Cohort Studies Cross-Sectional Studies Depression Exposure Farming Handling Humans Logistic Models Medical sciences Mental Disorders - chemically induced Mental Disorders - epidemiology Neuropsychiatric ill-health Occupational Exposure - adverse effects Occupational medicine Odds Ratio Organophosphates Pesticides Pesticides - adverse effects Pesticides, fertilizers and other agrochemicals toxicology Poisoning Populations Prevalence Public health. Hygiene-occupational medicine Sheep Surveys and Questionnaires Toxicology United Kingdom - epidemiology |
| title | Pesticide exposure and screen-positive neuropsychiatric disease in British sheep farmers |
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