Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice
•BBR prevented liver injury and mitochondrial oxidative damage induced by binge ethanol.•BBR reduced lipid peroxidation and CYP2E1 induction under the condition of chronic ethanol exposure.•BBR reduced hepatosteatosis partially through restoring PPARα/PGC-1α and HNF4α/MTTP pathways. Alcohol consumpt...
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| Veröffentlicht in: | Food and chemical toxicology 2014-12, Vol.74, p.225-232 |
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| creator | Zhang, Pengcheng Ma, Dongshen Wang, Yongchen Zhang, Miao Qiang, Xiaoyan Liao, Min Liu, Xie Wu, Hui Zhang, Yubin |
| description | •BBR prevented liver injury and mitochondrial oxidative damage induced by binge ethanol.•BBR reduced lipid peroxidation and CYP2E1 induction under the condition of chronic ethanol exposure.•BBR reduced hepatosteatosis partially through restoring PPARα/PGC-1α and HNF4α/MTTP pathways.
Alcohol consumption is customary in many cultures and it is a common human behavior worldwide. Binge ethanol and chronic alcohol consumption, two usual drinking patterns of human beings, produce a state of oxidative stress in liver and disturb the liver function. However, a safe and effective therapy for alcoholic liver disease in humans is still elusive. This study identified the natural product berberine as a potential agent for treating or preventing ethanol-induced liver injury. We demonstrated that berberine attenuated oxidative stress resulted from binge drinking in liver by reducing hepatic lipid peroxidation, glutathione exhaust and mitochondrial oxidative damage. Furthermore, berberine also prevented the oxidative stress and macrosteatosis in response to chronic ethanol exposure in mice. Either the total cytochrome P450 2E1 or the mitochondria-located cytochrome P450 2E1, which is implicated in ethanol-mediated oxidative stress, was suppressed by berberine. On the other hand, berberine significantly blunted the lipid accumulation in liver due to chronic alcohol consumption, at least partially, through restoring peroxisome proliferator-activated receptor α/peroxisome proliferator-activated receptor-gamma Co-activator-1α and hepatocyte nuclear factor 4α/microsomal triglyceride transfer protein pathways. These findings suggested that berberine could serve as a potential agent for preventing or treating human alcoholic liver disease. |
| doi_str_mv | 10.1016/j.fct.2014.10.005 |
| format | Article |
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Alcohol consumption is customary in many cultures and it is a common human behavior worldwide. Binge ethanol and chronic alcohol consumption, two usual drinking patterns of human beings, produce a state of oxidative stress in liver and disturb the liver function. However, a safe and effective therapy for alcoholic liver disease in humans is still elusive. This study identified the natural product berberine as a potential agent for treating or preventing ethanol-induced liver injury. We demonstrated that berberine attenuated oxidative stress resulted from binge drinking in liver by reducing hepatic lipid peroxidation, glutathione exhaust and mitochondrial oxidative damage. Furthermore, berberine also prevented the oxidative stress and macrosteatosis in response to chronic ethanol exposure in mice. Either the total cytochrome P450 2E1 or the mitochondria-located cytochrome P450 2E1, which is implicated in ethanol-mediated oxidative stress, was suppressed by berberine. On the other hand, berberine significantly blunted the lipid accumulation in liver due to chronic alcohol consumption, at least partially, through restoring peroxisome proliferator-activated receptor α/peroxisome proliferator-activated receptor-gamma Co-activator-1α and hepatocyte nuclear factor 4α/microsomal triglyceride transfer protein pathways. These findings suggested that berberine could serve as a potential agent for preventing or treating human alcoholic liver disease.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2014.10.005</identifier><identifier>PMID: 25455889</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Addictive behaviors ; Adult and adolescent clinical studies ; Alcoholic liver disease ; Alcoholism ; Alcoholism and acute alcohol poisoning ; Alcohols ; Animals ; Apoptosis - drug effects ; Berberine ; Berberine - pharmacology ; Binge Drinking - pathology ; Biological and medical sciences ; Central Nervous System Depressants - antagonists & inhibitors ; Central Nervous System Depressants - toxicity ; Consumption ; Cytochromes P450 ; Ethanol ; Ethanol - antagonists & inhibitors ; Ethanol - toxicity ; Ethyl alcohol ; Fatty Liver, Alcoholic - prevention & control ; Food toxicology ; Lipid Metabolism - drug effects ; Lipids ; Liver ; Liver Diseases, Alcoholic - prevention & control ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Mitochondria, Liver - drug effects ; Mitochondrial Swelling - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Protective Agents - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Signal Transduction - drug effects ; Steatosis ; Stresses ; Toxicology</subject><ispartof>Food and chemical toxicology, 2014-12, Vol.74, p.225-232</ispartof><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-306dd0075ae4a214cefff26de3892509b4345a0bc215999f345b60e9b897dad23</citedby><cites>FETCH-LOGICAL-c515t-306dd0075ae4a214cefff26de3892509b4345a0bc215999f345b60e9b897dad23</cites><orcidid>0000-0002-5586-6763</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2014.10.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29031819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25455889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Pengcheng</creatorcontrib><creatorcontrib>Ma, Dongshen</creatorcontrib><creatorcontrib>Wang, Yongchen</creatorcontrib><creatorcontrib>Zhang, Miao</creatorcontrib><creatorcontrib>Qiang, Xiaoyan</creatorcontrib><creatorcontrib>Liao, Min</creatorcontrib><creatorcontrib>Liu, Xie</creatorcontrib><creatorcontrib>Wu, Hui</creatorcontrib><creatorcontrib>Zhang, Yubin</creatorcontrib><title>Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>•BBR prevented liver injury and mitochondrial oxidative damage induced by binge ethanol.•BBR reduced lipid peroxidation and CYP2E1 induction under the condition of chronic ethanol exposure.•BBR reduced hepatosteatosis partially through restoring PPARα/PGC-1α and HNF4α/MTTP pathways.
Alcohol consumption is customary in many cultures and it is a common human behavior worldwide. Binge ethanol and chronic alcohol consumption, two usual drinking patterns of human beings, produce a state of oxidative stress in liver and disturb the liver function. However, a safe and effective therapy for alcoholic liver disease in humans is still elusive. This study identified the natural product berberine as a potential agent for treating or preventing ethanol-induced liver injury. We demonstrated that berberine attenuated oxidative stress resulted from binge drinking in liver by reducing hepatic lipid peroxidation, glutathione exhaust and mitochondrial oxidative damage. Furthermore, berberine also prevented the oxidative stress and macrosteatosis in response to chronic ethanol exposure in mice. Either the total cytochrome P450 2E1 or the mitochondria-located cytochrome P450 2E1, which is implicated in ethanol-mediated oxidative stress, was suppressed by berberine. On the other hand, berberine significantly blunted the lipid accumulation in liver due to chronic alcohol consumption, at least partially, through restoring peroxisome proliferator-activated receptor α/peroxisome proliferator-activated receptor-gamma Co-activator-1α and hepatocyte nuclear factor 4α/microsomal triglyceride transfer protein pathways. These findings suggested that berberine could serve as a potential agent for preventing or treating human alcoholic liver disease.</description><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcoholic liver disease</subject><subject>Alcoholism</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Alcohols</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Berberine</subject><subject>Berberine - pharmacology</subject><subject>Binge Drinking - pathology</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Depressants - antagonists & inhibitors</subject><subject>Central Nervous System Depressants - toxicity</subject><subject>Consumption</subject><subject>Cytochromes P450</subject><subject>Ethanol</subject><subject>Ethanol - antagonists & inhibitors</subject><subject>Ethanol - toxicity</subject><subject>Ethyl alcohol</subject><subject>Fatty Liver, Alcoholic - prevention & control</subject><subject>Food toxicology</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver Diseases, Alcoholic - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mitochondria, Liver - drug effects</subject><subject>Mitochondrial Swelling - drug effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Protective Agents - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Signal Transduction - drug effects</subject><subject>Steatosis</subject><subject>Stresses</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2PFCEQhonRuLOjP8CL4WLipUc-Ghriyd24arKJl_VMaCgik_5YKWaj_14mM-rN7AkKnqq8qYeQV5ztOOP63X6XQt0JxvtW7xhTT8iGm0F2Wir-lGyYGEynLVcX5BJxzxgb-KCfkwuheqWMsRtydwVlhJIXoPdlrRAq0ik_QKGprDOF-t0v69TlJR4CRLr-zNHX9k-xFkCkfontCr6umJHmhc45wAvyLPkJ4eX53JJvNx_vrj93t18_fbn-cNsFxVXtJNMxtkzKQ-8F7wOklISOII0Vitmxl73ybAyCK2ttatWoGdjR2CH6KOSWvD3NbdF_HACrmzMGmCa_wHpAx7Vu442V8hGoEnLQwjwG7Ye2ctMWvSX8hIayIhZI7r7k2ZdfjjN3VOT2rilyR0XHp6ao9bw-jz-MM8S_HX-cNODNGfAY_JSKX0LGf5xlkht-5N6fOGgrfshQHIYMS9OUS_Po4pr_E-M31Wmthg</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Zhang, Pengcheng</creator><creator>Ma, Dongshen</creator><creator>Wang, Yongchen</creator><creator>Zhang, Miao</creator><creator>Qiang, Xiaoyan</creator><creator>Liao, Min</creator><creator>Liu, Xie</creator><creator>Wu, Hui</creator><creator>Zhang, Yubin</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>7TB</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><orcidid>https://orcid.org/0000-0002-5586-6763</orcidid></search><sort><creationdate>20141201</creationdate><title>Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice</title><author>Zhang, Pengcheng ; Ma, Dongshen ; Wang, Yongchen ; Zhang, Miao ; Qiang, Xiaoyan ; Liao, Min ; Liu, Xie ; Wu, Hui ; Zhang, Yubin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-306dd0075ae4a214cefff26de3892509b4345a0bc215999f345b60e9b897dad23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Addictive behaviors</topic><topic>Adult and adolescent clinical studies</topic><topic>Alcoholic liver disease</topic><topic>Alcoholism</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Alcohols</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Berberine</topic><topic>Berberine - pharmacology</topic><topic>Binge Drinking - pathology</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Depressants - antagonists & inhibitors</topic><topic>Central Nervous System Depressants - toxicity</topic><topic>Consumption</topic><topic>Cytochromes P450</topic><topic>Ethanol</topic><topic>Ethanol - antagonists & inhibitors</topic><topic>Ethanol - toxicity</topic><topic>Ethyl alcohol</topic><topic>Fatty Liver, Alcoholic - prevention & control</topic><topic>Food toxicology</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver Diseases, Alcoholic - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mitochondria, Liver - drug effects</topic><topic>Mitochondrial Swelling - drug effects</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Protective Agents - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Signal Transduction - drug effects</topic><topic>Steatosis</topic><topic>Stresses</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Pengcheng</creatorcontrib><creatorcontrib>Ma, Dongshen</creatorcontrib><creatorcontrib>Wang, Yongchen</creatorcontrib><creatorcontrib>Zhang, Miao</creatorcontrib><creatorcontrib>Qiang, Xiaoyan</creatorcontrib><creatorcontrib>Liao, Min</creatorcontrib><creatorcontrib>Liu, Xie</creatorcontrib><creatorcontrib>Wu, Hui</creatorcontrib><creatorcontrib>Zhang, Yubin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Pengcheng</au><au>Ma, Dongshen</au><au>Wang, Yongchen</au><au>Zhang, Miao</au><au>Qiang, Xiaoyan</au><au>Liao, Min</au><au>Liu, Xie</au><au>Wu, Hui</au><au>Zhang, Yubin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>74</volume><spage>225</spage><epage>232</epage><pages>225-232</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>•BBR prevented liver injury and mitochondrial oxidative damage induced by binge ethanol.•BBR reduced lipid peroxidation and CYP2E1 induction under the condition of chronic ethanol exposure.•BBR reduced hepatosteatosis partially through restoring PPARα/PGC-1α and HNF4α/MTTP pathways.
Alcohol consumption is customary in many cultures and it is a common human behavior worldwide. Binge ethanol and chronic alcohol consumption, two usual drinking patterns of human beings, produce a state of oxidative stress in liver and disturb the liver function. However, a safe and effective therapy for alcoholic liver disease in humans is still elusive. This study identified the natural product berberine as a potential agent for treating or preventing ethanol-induced liver injury. We demonstrated that berberine attenuated oxidative stress resulted from binge drinking in liver by reducing hepatic lipid peroxidation, glutathione exhaust and mitochondrial oxidative damage. Furthermore, berberine also prevented the oxidative stress and macrosteatosis in response to chronic ethanol exposure in mice. Either the total cytochrome P450 2E1 or the mitochondria-located cytochrome P450 2E1, which is implicated in ethanol-mediated oxidative stress, was suppressed by berberine. On the other hand, berberine significantly blunted the lipid accumulation in liver due to chronic alcohol consumption, at least partially, through restoring peroxisome proliferator-activated receptor α/peroxisome proliferator-activated receptor-gamma Co-activator-1α and hepatocyte nuclear factor 4α/microsomal triglyceride transfer protein pathways. These findings suggested that berberine could serve as a potential agent for preventing or treating human alcoholic liver disease.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>25455889</pmid><doi>10.1016/j.fct.2014.10.005</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5586-6763</orcidid></addata></record> |
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| ispartof | Food and chemical toxicology, 2014-12, Vol.74, p.225-232 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Addictive behaviors Adult and adolescent clinical studies Alcoholic liver disease Alcoholism Alcoholism and acute alcohol poisoning Alcohols Animals Apoptosis - drug effects Berberine Berberine - pharmacology Binge Drinking - pathology Biological and medical sciences Central Nervous System Depressants - antagonists & inhibitors Central Nervous System Depressants - toxicity Consumption Cytochromes P450 Ethanol Ethanol - antagonists & inhibitors Ethanol - toxicity Ethyl alcohol Fatty Liver, Alcoholic - prevention & control Food toxicology Lipid Metabolism - drug effects Lipids Liver Liver Diseases, Alcoholic - prevention & control Male Medical sciences Mice Mice, Inbred ICR Mitochondria, Liver - drug effects Mitochondrial Swelling - drug effects Oxidative stress Oxidative Stress - drug effects Protective Agents - pharmacology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Signal Transduction - drug effects Steatosis Stresses Toxicology |
| title | Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice |
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