Mechanical properties and stem cell adhesion of injection-molded poly(ether ether ketone) and hydroxyapatite nanocomposites
ABSTRACT A nanocomposite of poly(ether ether ketone) (PEEK) with 10 wt % hydroxyapatite (HA) was produced by extrusion and injection molding. Afterward, the samples were thermally treated. Thermal and short‐ and long‐term mechanical characterizations of the samples were made. The adhesion of human a...
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| creator | Rego, Bruna Turino Neto, Wilson Alves Ribeiro de Paula, Ana Claudia Chagas Góes, Alfredo Miranda Bretas, Rosario Elida Suman |
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A nanocomposite of poly(ether ether ketone) (PEEK) with 10 wt % hydroxyapatite (HA) was produced by extrusion and injection molding. Afterward, the samples were thermally treated. Thermal and short‐ and long‐term mechanical characterizations of the samples were made. The adhesion of human adipose stem cells (h‐ASCs) on the samples was also monitored. The ultimate tensile strength (UTS) and elastic modulus values of the nanocomposite were found to be much higher than those of trabecular bone. The impact strength of PEEK was not modified by HA; this suggested that there was no formation of large agglomerates of nanoparticles that could concentrate the stresses. With regard to fatigue life, both the thermally and nonthermally treated nanocomposites did not fail after 106 cycles when maximum stresses of 30 and 50% of the UTS were applied, but they failed when the maximum applied stress was 75% of the UTS and behaved as cortical bone. After 5 days of culturing, the h‐ASCs had a higher proliferation in the nanocomposite than in pure PEEK because of the presence of HA. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41748. |
| doi_str_mv | 10.1002/app.41748 |
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A nanocomposite of poly(ether ether ketone) (PEEK) with 10 wt % hydroxyapatite (HA) was produced by extrusion and injection molding. Afterward, the samples were thermally treated. Thermal and short‐ and long‐term mechanical characterizations of the samples were made. The adhesion of human adipose stem cells (h‐ASCs) on the samples was also monitored. The ultimate tensile strength (UTS) and elastic modulus values of the nanocomposite were found to be much higher than those of trabecular bone. The impact strength of PEEK was not modified by HA; this suggested that there was no formation of large agglomerates of nanoparticles that could concentrate the stresses. With regard to fatigue life, both the thermally and nonthermally treated nanocomposites did not fail after 106 cycles when maximum stresses of 30 and 50% of the UTS were applied, but they failed when the maximum applied stress was 75% of the UTS and behaved as cortical bone. After 5 days of culturing, the h‐ASCs had a higher proliferation in the nanocomposite than in pure PEEK because of the presence of HA. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41748.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.41748</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken: Blackwell Publishing Ltd</publisher><subject>Adhesion ; biomedical applications ; Bones ; composites ; Ethers ; Hydroxyapatite ; Injection molding ; Materials science ; mechanical properties ; Nanocomposites ; Polyetheretherketones ; Polymers ; Stresses</subject><ispartof>Journal of applied polymer science, 2015-04, Vol.132 (14), p.np-n/a</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4388-2b42e260590f75749197ddcc2393435e1f1eea8f1d4de72ac2900756851eaed83</citedby><cites>FETCH-LOGICAL-c4388-2b42e260590f75749197ddcc2393435e1f1eea8f1d4de72ac2900756851eaed83</cites><orcidid>0000-0003-1883-2553</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.41748$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.41748$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids></links><search><creatorcontrib>Rego, Bruna Turino</creatorcontrib><creatorcontrib>Neto, Wilson Alves Ribeiro</creatorcontrib><creatorcontrib>de Paula, Ana Claudia Chagas</creatorcontrib><creatorcontrib>Góes, Alfredo Miranda</creatorcontrib><creatorcontrib>Bretas, Rosario Elida Suman</creatorcontrib><title>Mechanical properties and stem cell adhesion of injection-molded poly(ether ether ketone) and hydroxyapatite nanocomposites</title><title>Journal of applied polymer science</title><addtitle>J. Appl. Polym. Sci</addtitle><description>ABSTRACT
A nanocomposite of poly(ether ether ketone) (PEEK) with 10 wt % hydroxyapatite (HA) was produced by extrusion and injection molding. Afterward, the samples were thermally treated. Thermal and short‐ and long‐term mechanical characterizations of the samples were made. The adhesion of human adipose stem cells (h‐ASCs) on the samples was also monitored. The ultimate tensile strength (UTS) and elastic modulus values of the nanocomposite were found to be much higher than those of trabecular bone. The impact strength of PEEK was not modified by HA; this suggested that there was no formation of large agglomerates of nanoparticles that could concentrate the stresses. With regard to fatigue life, both the thermally and nonthermally treated nanocomposites did not fail after 106 cycles when maximum stresses of 30 and 50% of the UTS were applied, but they failed when the maximum applied stress was 75% of the UTS and behaved as cortical bone. After 5 days of culturing, the h‐ASCs had a higher proliferation in the nanocomposite than in pure PEEK because of the presence of HA. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41748.</description><subject>Adhesion</subject><subject>biomedical applications</subject><subject>Bones</subject><subject>composites</subject><subject>Ethers</subject><subject>Hydroxyapatite</subject><subject>Injection molding</subject><subject>Materials science</subject><subject>mechanical properties</subject><subject>Nanocomposites</subject><subject>Polyetheretherketones</subject><subject>Polymers</subject><subject>Stresses</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0EEkvhwD-wxKU9pPVnHB-rCragFio-xNEy9kTrbWIHOysa8edxG-CAxGVGo3ne0cy8CL2k5JQSws7sNJ0KqkT3CG0o0aoRLeseo03t0abTWj5Fz0rZE0KpJO0G_bwGt7MxODvgKacJ8hygYBs9LjOM2MEwYOt3UEKKOPU4xD24uRbNmAYPHk9pWI5h3kHGa7yFOUU4eZixW3xOd4ud7BxmwNHG5NI4pVKr8hw96e1Q4MXvfIS-vHn9-eKyufqwfXtxftU4wbuuYd8EA9YSqUmvpBKaauW9c4xrLrgE2lMA2_XUCw-KWcc0IUq2naRgwXf8CB2vc-uB3w9QZjOGcn-YjZAOxdC2rQImNKvoq3_QfTrkWLerlOC8_riVlTpZKZdTKRl6M-Uw2rwYSsy9DabaYB5sqOzZyv4IAyz_B835zc0fRbMqQnXg7q_C5lvTKq6k-fp-az593F5fSs3MO_4LFi6Z1A</recordid><startdate>20150410</startdate><enddate>20150410</enddate><creator>Rego, Bruna Turino</creator><creator>Neto, Wilson Alves Ribeiro</creator><creator>de Paula, Ana Claudia Chagas</creator><creator>Góes, Alfredo Miranda</creator><creator>Bretas, Rosario Elida Suman</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7U5</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-1883-2553</orcidid></search><sort><creationdate>20150410</creationdate><title>Mechanical properties and stem cell adhesion of injection-molded poly(ether ether ketone) and hydroxyapatite nanocomposites</title><author>Rego, Bruna Turino ; Neto, Wilson Alves Ribeiro ; de Paula, Ana Claudia Chagas ; Góes, Alfredo Miranda ; Bretas, Rosario Elida Suman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4388-2b42e260590f75749197ddcc2393435e1f1eea8f1d4de72ac2900756851eaed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adhesion</topic><topic>biomedical applications</topic><topic>Bones</topic><topic>composites</topic><topic>Ethers</topic><topic>Hydroxyapatite</topic><topic>Injection molding</topic><topic>Materials science</topic><topic>mechanical properties</topic><topic>Nanocomposites</topic><topic>Polyetheretherketones</topic><topic>Polymers</topic><topic>Stresses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rego, Bruna Turino</creatorcontrib><creatorcontrib>Neto, Wilson Alves Ribeiro</creatorcontrib><creatorcontrib>de Paula, Ana Claudia Chagas</creatorcontrib><creatorcontrib>Góes, Alfredo Miranda</creatorcontrib><creatorcontrib>Bretas, Rosario Elida Suman</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rego, Bruna Turino</au><au>Neto, Wilson Alves Ribeiro</au><au>de Paula, Ana Claudia Chagas</au><au>Góes, Alfredo Miranda</au><au>Bretas, Rosario Elida Suman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical properties and stem cell adhesion of injection-molded poly(ether ether ketone) and hydroxyapatite nanocomposites</atitle><jtitle>Journal of applied polymer science</jtitle><addtitle>J. Appl. Polym. Sci</addtitle><date>2015-04-10</date><risdate>2015</risdate><volume>132</volume><issue>14</issue><spage>np</spage><epage>n/a</epage><pages>np-n/a</pages><issn>0021-8995</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>ABSTRACT
A nanocomposite of poly(ether ether ketone) (PEEK) with 10 wt % hydroxyapatite (HA) was produced by extrusion and injection molding. Afterward, the samples were thermally treated. Thermal and short‐ and long‐term mechanical characterizations of the samples were made. The adhesion of human adipose stem cells (h‐ASCs) on the samples was also monitored. The ultimate tensile strength (UTS) and elastic modulus values of the nanocomposite were found to be much higher than those of trabecular bone. The impact strength of PEEK was not modified by HA; this suggested that there was no formation of large agglomerates of nanoparticles that could concentrate the stresses. With regard to fatigue life, both the thermally and nonthermally treated nanocomposites did not fail after 106 cycles when maximum stresses of 30 and 50% of the UTS were applied, but they failed when the maximum applied stress was 75% of the UTS and behaved as cortical bone. After 5 days of culturing, the h‐ASCs had a higher proliferation in the nanocomposite than in pure PEEK because of the presence of HA. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41748.</abstract><cop>Hoboken</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1002/app.41748</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-1883-2553</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Adhesion biomedical applications Bones composites Ethers Hydroxyapatite Injection molding Materials science mechanical properties Nanocomposites Polyetheretherketones Polymers Stresses |
| title | Mechanical properties and stem cell adhesion of injection-molded poly(ether ether ketone) and hydroxyapatite nanocomposites |
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