Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup
A set of four reference materials for the detection and quantification of silica nanoparticles (NPs) in food was produced as a proof of principle exercise. Neat silica suspensions were ampouled, tested for homogeneity and stability, and characterized for total silica content as well as particle diam...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2014-06, Vol.406 (16), p.3895-3907 |
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| creator | Grombe, Ringo Charoud-Got, Jean Emteborg, Håkan Linsinger, Thomas P. J. Seghers, John Wagner, Stephan von der Kammer, Frank Hofmann, Thilo Dudkiewicz, Agnieszka Llinas, Meritxell Solans, Conxita Lehner, Angela Allmaier, Günter |
| description | A set of four reference materials for the detection and quantification of silica nanoparticles (NPs) in food was produced as a proof of principle exercise. Neat silica suspensions were ampouled, tested for homogeneity and stability, and characterized for total silica content as well as particle diameter by dynamic light scattering (DLS), electron microscopy (EM), gas-phase electrophoretic molecular mobility analysis (GEMMA), and field-flow fractionation coupled with an inductively coupled mass spectrometer (FFF-ICPMS). Tomato soup was prepared from ingredients free of engineered nanoparticles and was spiked at two concentration levels with the silica NP suspension. Homogeneity of these materials was found sufficient to act as reference materials and the materials are sufficiently stable to allow long-term storage and distribution at ambient temperature, providing proof of principle of the feasibility of producing liquid food reference materials for the detection of nanoparticles. The spiked soups were characterized for particle diameter by EM and FFF-ICPMS (one material only), as well as for the total silica content. Although questions regarding the trueness of the results from EM and FFF-ICPMS procedures remain, the data obtained indicate that even assigning values should eventually be feasible. The materials can therefore be regarded as the first step towards certified reference materials for silica nanoparticles in a food matrix. |
| doi_str_mv | 10.1007/s00216-013-7554-1 |
| format | Article |
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J. ; Seghers, John ; Wagner, Stephan ; von der Kammer, Frank ; Hofmann, Thilo ; Dudkiewicz, Agnieszka ; Llinas, Meritxell ; Solans, Conxita ; Lehner, Angela ; Allmaier, Günter</creator><creatorcontrib>Grombe, Ringo ; Charoud-Got, Jean ; Emteborg, Håkan ; Linsinger, Thomas P. J. ; Seghers, John ; Wagner, Stephan ; von der Kammer, Frank ; Hofmann, Thilo ; Dudkiewicz, Agnieszka ; Llinas, Meritxell ; Solans, Conxita ; Lehner, Angela ; Allmaier, Günter</creatorcontrib><description>A set of four reference materials for the detection and quantification of silica nanoparticles (NPs) in food was produced as a proof of principle exercise. Neat silica suspensions were ampouled, tested for homogeneity and stability, and characterized for total silica content as well as particle diameter by dynamic light scattering (DLS), electron microscopy (EM), gas-phase electrophoretic molecular mobility analysis (GEMMA), and field-flow fractionation coupled with an inductively coupled mass spectrometer (FFF-ICPMS). Tomato soup was prepared from ingredients free of engineered nanoparticles and was spiked at two concentration levels with the silica NP suspension. Homogeneity of these materials was found sufficient to act as reference materials and the materials are sufficiently stable to allow long-term storage and distribution at ambient temperature, providing proof of principle of the feasibility of producing liquid food reference materials for the detection of nanoparticles. The spiked soups were characterized for particle diameter by EM and FFF-ICPMS (one material only), as well as for the total silica content. Although questions regarding the trueness of the results from EM and FFF-ICPMS procedures remain, the data obtained indicate that even assigning values should eventually be feasible. The materials can therefore be regarded as the first step towards certified reference materials for silica nanoparticles in a food matrix.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-013-7554-1</identifier><identifier>PMID: 24390460</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Ambient temperature ; Analytical Chemistry ; Atomic properties ; Biochemistry ; Biological samples ; Characterisation of Nanomaterials in Biological Samples ; Characterization and Evaluation of Materials ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Composition ; Contamination ; Food ; Food contamination ; Food Contamination - analysis ; Food matrix ; Food Science ; Foods ; Fractionation ; Homogeneity ; Identification and classification ; Laboratory Medicine ; Light scattering ; Lycopersicon esculentum - chemistry ; Mass Spectrometry ; Methods ; Microscopy ; Microscopy, Electron, Transmission ; Monitoring/Environmental Analysis ; Nanomaterials ; Nanoparticles ; Nanoparticles - chemistry ; Nanotechnology ; Particle Size ; Proving ; Reference materials ; Research Paper ; Scattering, Radiation ; Silica ; Silicon dioxide ; Silicon Dioxide - chemistry ; Soups ; Tomato products ; Tomatoes</subject><ispartof>Analytical and bioanalytical chemistry, 2014-06, Vol.406 (16), p.3895-3907</ispartof><rights>European Union 2013</rights><rights>COPYRIGHT 2014 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-9b43ca7d6ae6c075d6f10bb0ef3f2455ff5ccb6e505f3ed24d6a282b3bffb4a3</citedby><cites>FETCH-LOGICAL-c542t-9b43ca7d6ae6c075d6f10bb0ef3f2455ff5ccb6e505f3ed24d6a282b3bffb4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-013-7554-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-013-7554-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24390460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grombe, Ringo</creatorcontrib><creatorcontrib>Charoud-Got, Jean</creatorcontrib><creatorcontrib>Emteborg, Håkan</creatorcontrib><creatorcontrib>Linsinger, Thomas P. J.</creatorcontrib><creatorcontrib>Seghers, John</creatorcontrib><creatorcontrib>Wagner, Stephan</creatorcontrib><creatorcontrib>von der Kammer, Frank</creatorcontrib><creatorcontrib>Hofmann, Thilo</creatorcontrib><creatorcontrib>Dudkiewicz, Agnieszka</creatorcontrib><creatorcontrib>Llinas, Meritxell</creatorcontrib><creatorcontrib>Solans, Conxita</creatorcontrib><creatorcontrib>Lehner, Angela</creatorcontrib><creatorcontrib>Allmaier, Günter</creatorcontrib><title>Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>A set of four reference materials for the detection and quantification of silica nanoparticles (NPs) in food was produced as a proof of principle exercise. Neat silica suspensions were ampouled, tested for homogeneity and stability, and characterized for total silica content as well as particle diameter by dynamic light scattering (DLS), electron microscopy (EM), gas-phase electrophoretic molecular mobility analysis (GEMMA), and field-flow fractionation coupled with an inductively coupled mass spectrometer (FFF-ICPMS). Tomato soup was prepared from ingredients free of engineered nanoparticles and was spiked at two concentration levels with the silica NP suspension. Homogeneity of these materials was found sufficient to act as reference materials and the materials are sufficiently stable to allow long-term storage and distribution at ambient temperature, providing proof of principle of the feasibility of producing liquid food reference materials for the detection of nanoparticles. The spiked soups were characterized for particle diameter by EM and FFF-ICPMS (one material only), as well as for the total silica content. Although questions regarding the trueness of the results from EM and FFF-ICPMS procedures remain, the data obtained indicate that even assigning values should eventually be feasible. The materials can therefore be regarded as the first step towards certified reference materials for silica nanoparticles in a food matrix.</description><subject>Ambient temperature</subject><subject>Analytical Chemistry</subject><subject>Atomic properties</subject><subject>Biochemistry</subject><subject>Biological samples</subject><subject>Characterisation of Nanomaterials in Biological Samples</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composition</subject><subject>Contamination</subject><subject>Food</subject><subject>Food contamination</subject><subject>Food Contamination - analysis</subject><subject>Food matrix</subject><subject>Food Science</subject><subject>Foods</subject><subject>Fractionation</subject><subject>Homogeneity</subject><subject>Identification and classification</subject><subject>Laboratory Medicine</subject><subject>Light scattering</subject><subject>Lycopersicon esculentum - chemistry</subject><subject>Mass Spectrometry</subject><subject>Methods</subject><subject>Microscopy</subject><subject>Microscopy, Electron, Transmission</subject><subject>Monitoring/Environmental Analysis</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology</subject><subject>Particle Size</subject><subject>Proving</subject><subject>Reference materials</subject><subject>Research Paper</subject><subject>Scattering, Radiation</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - chemistry</subject><subject>Soups</subject><subject>Tomato products</subject><subject>Tomatoes</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkstu3SAQhlHVqknTPkA3FVI33ThhMGC8jKLepEjJInuE8ZAS2XAC9qJ9-nDkJL2oVSMWoOGbn5nhJ-QtsGNgrDspjHFQDYO26aQUDTwjh6BAN1xJ9vzxLPgBeVXKDWMgNaiX5ICLtmdCsUNye5nTuLolpEiTpxk9ZowO6WwXzMFOhfqU6fIN6YgLbqCNIy3hxxbKc4j2Ib-EKThLo41pZ_MS3ISFhkiXVPUSLWndvSYvfJXFN_f7Ebn69PHq7EtzfvH569npeeOk4EvTD6J1thuVReVYJ0flgQ0DQ996LqT0Xjo3KJRM-hZHLirJNR_awftB2PaIfNhkdzndrlgWM4ficJpsxLQWA0rVEULX6f-jUnV13roXT0Bb6CUo3Vf0_R_oTVpzrC3XtzvGldYCflLXdkITok9Ltm4vak5b3WneA7BKHf-FqmvEObgU0Yca_y0BtgSXUyn1V80uh9nm7waY2XvHbN4x1Ttm7x2zL-XdfcHrMOP4mPFglgrwDSj1Kl5j_qWjf6reAXLYzjk</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Grombe, Ringo</creator><creator>Charoud-Got, Jean</creator><creator>Emteborg, Håkan</creator><creator>Linsinger, Thomas P. 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J.</au><au>Seghers, John</au><au>Wagner, Stephan</au><au>von der Kammer, Frank</au><au>Hofmann, Thilo</au><au>Dudkiewicz, Agnieszka</au><au>Llinas, Meritxell</au><au>Solans, Conxita</au><au>Lehner, Angela</au><au>Allmaier, Günter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>406</volume><issue>16</issue><spage>3895</spage><epage>3907</epage><pages>3895-3907</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>A set of four reference materials for the detection and quantification of silica nanoparticles (NPs) in food was produced as a proof of principle exercise. Neat silica suspensions were ampouled, tested for homogeneity and stability, and characterized for total silica content as well as particle diameter by dynamic light scattering (DLS), electron microscopy (EM), gas-phase electrophoretic molecular mobility analysis (GEMMA), and field-flow fractionation coupled with an inductively coupled mass spectrometer (FFF-ICPMS). Tomato soup was prepared from ingredients free of engineered nanoparticles and was spiked at two concentration levels with the silica NP suspension. Homogeneity of these materials was found sufficient to act as reference materials and the materials are sufficiently stable to allow long-term storage and distribution at ambient temperature, providing proof of principle of the feasibility of producing liquid food reference materials for the detection of nanoparticles. The spiked soups were characterized for particle diameter by EM and FFF-ICPMS (one material only), as well as for the total silica content. Although questions regarding the trueness of the results from EM and FFF-ICPMS procedures remain, the data obtained indicate that even assigning values should eventually be feasible. The materials can therefore be regarded as the first step towards certified reference materials for silica nanoparticles in a food matrix.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24390460</pmid><doi>10.1007/s00216-013-7554-1</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Ambient temperature Analytical Chemistry Atomic properties Biochemistry Biological samples Characterisation of Nanomaterials in Biological Samples Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Composition Contamination Food Food contamination Food Contamination - analysis Food matrix Food Science Foods Fractionation Homogeneity Identification and classification Laboratory Medicine Light scattering Lycopersicon esculentum - chemistry Mass Spectrometry Methods Microscopy Microscopy, Electron, Transmission Monitoring/Environmental Analysis Nanomaterials Nanoparticles Nanoparticles - chemistry Nanotechnology Particle Size Proving Reference materials Research Paper Scattering, Radiation Silica Silicon dioxide Silicon Dioxide - chemistry Soups Tomato products Tomatoes |
| title | Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup |
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