Bioappearance and pharmacokinetics of bioactives upon coffee consumption
Habitual consumption of medium amounts of coffee over the whole life-span is hypothesized to reduce the risk to develop diabetes type 2 (DM2) and Alzheimer’s disease (AD). To identify putative bioactive coffee-derived metabolites, first, pooled urine from coffee drinkers and non-coffee drinkers were...
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| description | Habitual consumption of medium amounts of coffee over the whole life-span is hypothesized to reduce the risk to develop diabetes type 2 (DM2) and Alzheimer’s disease (AD). To identify putative bioactive coffee-derived metabolites, first, pooled urine from coffee drinkers and non-coffee drinkers were screened by UPLC-HDMS. After statistical data analysis, trigonelline, dimethylxanthines and monomethylxanthines, and ferulic acid conjugates were identified as the major metabolites found after coffee consumption. For quantitative analysis of these markers in body fluids, targeted methods based on stable-isotope dilution and UPLC-MS/MS were developed and applied to plasma samples from a coffee intervention study (
n
= 13 volunteers) who consumed a single cup of caffeinated coffee brew after a 10-day washout period. Chlorogenic acid-derived metabolites were found to be separated into two groups showing different pharmacokinetic properties. The first group comprised, e.g., ferulic acid and feruloyl sulfate and showed early appearance in the plasma (∼1 h). The second group contained particularly chlorogenic acid metabolites formed by the intestinal microflora, appearing late and persisting in the plasma (>6 h). Trigonelline appeared early but persisted with calculated half-life times ∼5 h. The plasma levels of caffeine metabolites significantly and progressively increased 2–4 h after coffee consumption and did not reach
c
max
within the time frame of the study. The pharmacokinetic profiles suggest that particularly trigonelline, caffeine, its metabolites, as well as late appearing dihydroferulic acid, feruloylglycine and dihydroferulic acid sulfate formed from chlorogenic acid by the intestinal microflora accumulate in the plasma due to their long half-life times during habitual consumption of several cups of coffee distributed over the day. Since some of these metabolites have been reported to show antioxidant effects in vivo, antioxidant-response-element activating potential, and neuroprotective properties, respectively, some of these key metabolites might account for the inflammation- and DM2/AD risk reducing effects reported for habitual life time consumption of coffee.
Figure
Identification of coffee key metabolites in human urine using untargeted MS-based profiling and subsequent targeted analyses in plasma using stable isotope dilution assays |
| doi_str_mv | 10.1007/s00216-013-7288-0 |
| format | Article |
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n
= 13 volunteers) who consumed a single cup of caffeinated coffee brew after a 10-day washout period. Chlorogenic acid-derived metabolites were found to be separated into two groups showing different pharmacokinetic properties. The first group comprised, e.g., ferulic acid and feruloyl sulfate and showed early appearance in the plasma (∼1 h). The second group contained particularly chlorogenic acid metabolites formed by the intestinal microflora, appearing late and persisting in the plasma (>6 h). Trigonelline appeared early but persisted with calculated half-life times ∼5 h. The plasma levels of caffeine metabolites significantly and progressively increased 2–4 h after coffee consumption and did not reach
c
max
within the time frame of the study. The pharmacokinetic profiles suggest that particularly trigonelline, caffeine, its metabolites, as well as late appearing dihydroferulic acid, feruloylglycine and dihydroferulic acid sulfate formed from chlorogenic acid by the intestinal microflora accumulate in the plasma due to their long half-life times during habitual consumption of several cups of coffee distributed over the day. Since some of these metabolites have been reported to show antioxidant effects in vivo, antioxidant-response-element activating potential, and neuroprotective properties, respectively, some of these key metabolites might account for the inflammation- and DM2/AD risk reducing effects reported for habitual life time consumption of coffee.
Figure
Identification of coffee key metabolites in human urine using untargeted MS-based profiling and subsequent targeted analyses in plasma using stable isotope dilution assays</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-013-7288-0</identifier><identifier>PMID: 23982107</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acids ; Adult ; Alkaloids - blood ; Alkaloids - metabolism ; Alkaloids - urine ; Alzheimer's disease ; Analytical Chemistry ; Antioxidants ; Biochemistry ; Biocompatibility ; Biomedical materials ; Caffeine ; Caffeine - blood ; Caffeine - metabolism ; Caffeine - urine ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chlorogenic acid ; Chlorogenic Acid - blood ; Chlorogenic Acid - metabolism ; Chlorogenic Acid - urine ; Coffee ; Coffee - metabolism ; Coumaric Acids - blood ; Coumaric Acids - metabolism ; Coumaric Acids - urine ; Diabetes ; Female ; Food Science ; Health aspects ; Humans ; Laboratory Medicine ; Male ; Mass spectrometry ; Metabolites ; Monitoring/Environmental Analysis ; Nanotechnology ; Pharmacokinetics ; Phytochemicals ; Plasma ; Quantitative analysis ; Research Paper ; Risk ; Risk factors ; Statistical analysis ; Sulfates ; Surgical implants ; Tandem Mass Spectrometry ; Xanthines - blood ; Xanthines - metabolism ; Xanthines - urine ; Young Adult</subject><ispartof>Analytical and bioanalytical chemistry, 2013-10, Vol.405 (26), p.8487-8503</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-f2bd5d61349bceb8c9b548af9bee67be8ffcd3b99a795229e36ff2f0490b96433</citedby><cites>FETCH-LOGICAL-c542t-f2bd5d61349bceb8c9b548af9bee67be8ffcd3b99a795229e36ff2f0490b96433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-013-7288-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-013-7288-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23982107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lang, Roman</creatorcontrib><creatorcontrib>Dieminger, Natalie</creatorcontrib><creatorcontrib>Beusch, Anja</creatorcontrib><creatorcontrib>Lee, Yu-Mi</creatorcontrib><creatorcontrib>Dunkel, Andreas</creatorcontrib><creatorcontrib>Suess, Barbara</creatorcontrib><creatorcontrib>Skurk, Thomas</creatorcontrib><creatorcontrib>Wahl, Anika</creatorcontrib><creatorcontrib>Hauner, Hans</creatorcontrib><creatorcontrib>Hofmann, Thomas</creatorcontrib><title>Bioappearance and pharmacokinetics of bioactives upon coffee consumption</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Habitual consumption of medium amounts of coffee over the whole life-span is hypothesized to reduce the risk to develop diabetes type 2 (DM2) and Alzheimer’s disease (AD). To identify putative bioactive coffee-derived metabolites, first, pooled urine from coffee drinkers and non-coffee drinkers were screened by UPLC-HDMS. After statistical data analysis, trigonelline, dimethylxanthines and monomethylxanthines, and ferulic acid conjugates were identified as the major metabolites found after coffee consumption. For quantitative analysis of these markers in body fluids, targeted methods based on stable-isotope dilution and UPLC-MS/MS were developed and applied to plasma samples from a coffee intervention study (
n
= 13 volunteers) who consumed a single cup of caffeinated coffee brew after a 10-day washout period. Chlorogenic acid-derived metabolites were found to be separated into two groups showing different pharmacokinetic properties. The first group comprised, e.g., ferulic acid and feruloyl sulfate and showed early appearance in the plasma (∼1 h). The second group contained particularly chlorogenic acid metabolites formed by the intestinal microflora, appearing late and persisting in the plasma (>6 h). Trigonelline appeared early but persisted with calculated half-life times ∼5 h. The plasma levels of caffeine metabolites significantly and progressively increased 2–4 h after coffee consumption and did not reach
c
max
within the time frame of the study. The pharmacokinetic profiles suggest that particularly trigonelline, caffeine, its metabolites, as well as late appearing dihydroferulic acid, feruloylglycine and dihydroferulic acid sulfate formed from chlorogenic acid by the intestinal microflora accumulate in the plasma due to their long half-life times during habitual consumption of several cups of coffee distributed over the day. Since some of these metabolites have been reported to show antioxidant effects in vivo, antioxidant-response-element activating potential, and neuroprotective properties, respectively, some of these key metabolites might account for the inflammation- and DM2/AD risk reducing effects reported for habitual life time consumption of coffee.
Figure
Identification of coffee key metabolites in human urine using untargeted MS-based profiling and subsequent targeted analyses in plasma using stable isotope dilution assays</description><subject>Acids</subject><subject>Adult</subject><subject>Alkaloids - blood</subject><subject>Alkaloids - metabolism</subject><subject>Alkaloids - urine</subject><subject>Alzheimer's disease</subject><subject>Analytical Chemistry</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Caffeine</subject><subject>Caffeine - blood</subject><subject>Caffeine - metabolism</subject><subject>Caffeine - urine</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chlorogenic acid</subject><subject>Chlorogenic Acid - blood</subject><subject>Chlorogenic Acid - metabolism</subject><subject>Chlorogenic Acid - urine</subject><subject>Coffee</subject><subject>Coffee - metabolism</subject><subject>Coumaric Acids - blood</subject><subject>Coumaric Acids - metabolism</subject><subject>Coumaric Acids - urine</subject><subject>Diabetes</subject><subject>Female</subject><subject>Food Science</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Metabolites</subject><subject>Monitoring/Environmental Analysis</subject><subject>Nanotechnology</subject><subject>Pharmacokinetics</subject><subject>Phytochemicals</subject><subject>Plasma</subject><subject>Quantitative analysis</subject><subject>Research Paper</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Sulfates</subject><subject>Surgical implants</subject><subject>Tandem Mass Spectrometry</subject><subject>Xanthines - blood</subject><subject>Xanthines - metabolism</subject><subject>Xanthines - urine</subject><subject>Young Adult</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk9vFSEUxYnR2Fr9AG7MJG7cTL38GQaWtVFr0sSNrgkwl0p9AyPMNPHby8urTTUaDYtL4HcO3JtDyHMKpxRgfF0BGJU9UN6PTKkeHpBjKqnqmRzg4d1esCPypNZrADooKh-TI8a1YhTGY3LxJma7LGiLTR47m6Zu-WLLbH3-GhOu0dcuh841yq_xBmu3LTl1PoeA2Eqq27ysMaen5FGwu4rPbusJ-fzu7afzi_7y4_sP52eXvR8EW_vA3DRMknKhnUenvHaDUDZohyhHhyoEP3GntR31wJhGLkNgAYQGp6Xg_IS8OvguJX_bsK5mjtXjbmcT5q0aKmUbTWtU_hsVuhm2qfwPKvQouRKioS9_Q6_zVlLrub09AhONu0dd2R2amEJei_V7U3PGxShgULCnTv9AtTXhHNtwMcR2_ouAHgS-5FoLBrOUONvy3VAw-0yYQyZMy4TZZ8JA07y4_fDmZpzuFD9D0AB2AGq7SldY7nX0V9cfKxa-zA</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Lang, Roman</creator><creator>Dieminger, Natalie</creator><creator>Beusch, Anja</creator><creator>Lee, Yu-Mi</creator><creator>Dunkel, Andreas</creator><creator>Suess, Barbara</creator><creator>Skurk, Thomas</creator><creator>Wahl, Anika</creator><creator>Hauner, Hans</creator><creator>Hofmann, Thomas</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7QH</scope><scope>7UA</scope></search><sort><creationdate>20131001</creationdate><title>Bioappearance and pharmacokinetics of bioactives upon coffee consumption</title><author>Lang, Roman ; Dieminger, Natalie ; Beusch, Anja ; Lee, Yu-Mi ; Dunkel, Andreas ; Suess, Barbara ; Skurk, Thomas ; Wahl, Anika ; Hauner, Hans ; Hofmann, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-f2bd5d61349bceb8c9b548af9bee67be8ffcd3b99a795229e36ff2f0490b96433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Alkaloids - blood</topic><topic>Alkaloids - metabolism</topic><topic>Alkaloids - urine</topic><topic>Alzheimer's disease</topic><topic>Analytical Chemistry</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Caffeine</topic><topic>Caffeine - blood</topic><topic>Caffeine - metabolism</topic><topic>Caffeine - urine</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chlorogenic acid</topic><topic>Chlorogenic Acid - blood</topic><topic>Chlorogenic Acid - metabolism</topic><topic>Chlorogenic Acid - urine</topic><topic>Coffee</topic><topic>Coffee - metabolism</topic><topic>Coumaric Acids - blood</topic><topic>Coumaric Acids - metabolism</topic><topic>Coumaric Acids - urine</topic><topic>Diabetes</topic><topic>Female</topic><topic>Food Science</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Metabolites</topic><topic>Monitoring/Environmental Analysis</topic><topic>Nanotechnology</topic><topic>Pharmacokinetics</topic><topic>Phytochemicals</topic><topic>Plasma</topic><topic>Quantitative analysis</topic><topic>Research Paper</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Sulfates</topic><topic>Surgical implants</topic><topic>Tandem Mass Spectrometry</topic><topic>Xanthines - blood</topic><topic>Xanthines - metabolism</topic><topic>Xanthines - urine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lang, Roman</creatorcontrib><creatorcontrib>Dieminger, Natalie</creatorcontrib><creatorcontrib>Beusch, Anja</creatorcontrib><creatorcontrib>Lee, Yu-Mi</creatorcontrib><creatorcontrib>Dunkel, Andreas</creatorcontrib><creatorcontrib>Suess, Barbara</creatorcontrib><creatorcontrib>Skurk, Thomas</creatorcontrib><creatorcontrib>Wahl, Anika</creatorcontrib><creatorcontrib>Hauner, Hans</creatorcontrib><creatorcontrib>Hofmann, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Roman</au><au>Dieminger, Natalie</au><au>Beusch, Anja</au><au>Lee, Yu-Mi</au><au>Dunkel, Andreas</au><au>Suess, Barbara</au><au>Skurk, Thomas</au><au>Wahl, Anika</au><au>Hauner, Hans</au><au>Hofmann, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioappearance and pharmacokinetics of bioactives upon coffee consumption</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>405</volume><issue>26</issue><spage>8487</spage><epage>8503</epage><pages>8487-8503</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Habitual consumption of medium amounts of coffee over the whole life-span is hypothesized to reduce the risk to develop diabetes type 2 (DM2) and Alzheimer’s disease (AD). To identify putative bioactive coffee-derived metabolites, first, pooled urine from coffee drinkers and non-coffee drinkers were screened by UPLC-HDMS. After statistical data analysis, trigonelline, dimethylxanthines and monomethylxanthines, and ferulic acid conjugates were identified as the major metabolites found after coffee consumption. For quantitative analysis of these markers in body fluids, targeted methods based on stable-isotope dilution and UPLC-MS/MS were developed and applied to plasma samples from a coffee intervention study (
n
= 13 volunteers) who consumed a single cup of caffeinated coffee brew after a 10-day washout period. Chlorogenic acid-derived metabolites were found to be separated into two groups showing different pharmacokinetic properties. The first group comprised, e.g., ferulic acid and feruloyl sulfate and showed early appearance in the plasma (∼1 h). The second group contained particularly chlorogenic acid metabolites formed by the intestinal microflora, appearing late and persisting in the plasma (>6 h). Trigonelline appeared early but persisted with calculated half-life times ∼5 h. The plasma levels of caffeine metabolites significantly and progressively increased 2–4 h after coffee consumption and did not reach
c
max
within the time frame of the study. The pharmacokinetic profiles suggest that particularly trigonelline, caffeine, its metabolites, as well as late appearing dihydroferulic acid, feruloylglycine and dihydroferulic acid sulfate formed from chlorogenic acid by the intestinal microflora accumulate in the plasma due to their long half-life times during habitual consumption of several cups of coffee distributed over the day. Since some of these metabolites have been reported to show antioxidant effects in vivo, antioxidant-response-element activating potential, and neuroprotective properties, respectively, some of these key metabolites might account for the inflammation- and DM2/AD risk reducing effects reported for habitual life time consumption of coffee.
Figure
Identification of coffee key metabolites in human urine using untargeted MS-based profiling and subsequent targeted analyses in plasma using stable isotope dilution assays</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23982107</pmid><doi>10.1007/s00216-013-7288-0</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1618-2642 |
| ispartof | Analytical and bioanalytical chemistry, 2013-10, Vol.405 (26), p.8487-8503 |
| issn | 1618-2642 1618-2650 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acids Adult Alkaloids - blood Alkaloids - metabolism Alkaloids - urine Alzheimer's disease Analytical Chemistry Antioxidants Biochemistry Biocompatibility Biomedical materials Caffeine Caffeine - blood Caffeine - metabolism Caffeine - urine Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chlorogenic acid Chlorogenic Acid - blood Chlorogenic Acid - metabolism Chlorogenic Acid - urine Coffee Coffee - metabolism Coumaric Acids - blood Coumaric Acids - metabolism Coumaric Acids - urine Diabetes Female Food Science Health aspects Humans Laboratory Medicine Male Mass spectrometry Metabolites Monitoring/Environmental Analysis Nanotechnology Pharmacokinetics Phytochemicals Plasma Quantitative analysis Research Paper Risk Risk factors Statistical analysis Sulfates Surgical implants Tandem Mass Spectrometry Xanthines - blood Xanthines - metabolism Xanthines - urine Young Adult |
| title | Bioappearance and pharmacokinetics of bioactives upon coffee consumption |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T19%3A28%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioappearance%20and%20pharmacokinetics%20of%20bioactives%20upon%20coffee%20consumption&rft.jtitle=Analytical%20and%20bioanalytical%20chemistry&rft.au=Lang,%20Roman&rft.date=2013-10-01&rft.volume=405&rft.issue=26&rft.spage=8487&rft.epage=8503&rft.pages=8487-8503&rft.issn=1618-2642&rft.eissn=1618-2650&rft_id=info:doi/10.1007/s00216-013-7288-0&rft_dat=%3Cgale_proqu%3EA347405804%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1670247634&rft_id=info:pmid/23982107&rft_galeid=A347405804&rfr_iscdi=true |