The interaction of platinum-based drugs with native biologically relevant proteins

This study focuses on the identification of the products that are formed upon binding of therapeutically relevant platinum complexes to proteins like β-lactoglobulin A (LGA), human serum albumin (HSA), or human hemoglobin (HB). The respective proteins were incubated with the platinum-based anticance...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2013-02, Vol.405 (6), p.1855-1864
Hauptverfasser:	Brauckmann, Christine, Wehe, Christoph A., Kieshauer, Michael, Lanvers-Kaminsky, Claudia, Sperling, Michael, Karst, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Ammonia Analytical Chemistry Antimitotic agents Antineoplastic agents Antineoplastic Agents - blood Binding sites Biochemistry Cancer Carboplatin - blood Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Chromatography Chromatography, Liquid Cisplatin - blood Drug interactions Drugs Experiments Food Science Hemoglobin Hemoglobins - chemistry Human Humans Identification and classification Ionization Laboratory Medicine Lactoglobulins - blood Liquid chromatography Mass spectrometry Monitoring/Environmental Analysis Organoplatinum Compounds - blood Original Paper Oxidation-Reduction Plasma Platinum Platinum - analysis Protein Binding Proteins Scientific imaging Serum Albumin - chemistry Sodium Chloride - chemistry Spectrometry, Mass, Electrospray Ionization Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Thiols
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