Enhanced Tumor Targeting and Photocytotoxicity of Folate–Poly(ethylene glycol)–Chlorin Photosensitizer Mediated by Folate Receptor

A targeting and water-soluble photosensitizer folate–PEG–chlorin (I) has been synthesized and characterized. The uptake of conjugate I by HeLa and Hep-2 cells was much higher than the uptake by A549 cells, and can be inhibited by folic acid. Conjugate I exhibited much lower cytotoxicity against HeLa...

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Veröffentlicht in:	Chemistry letters 2013-02, Vol.42 (2), p.130-131
Hauptverfasser:	Li, Donghong, Li, Pengxi, Jiang, Zonglin, Guo, Linfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Conjugates Folic acid Membranes Mitochondria Receptors Tumors Uptakes
Online-Zugang:	Volltext
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