Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier

The transdermal administration of chemotherapeutic agents is a persistent challenge for tumor treatments. A model anticancer agent, epirubicin (EPI), is attached to functionalized superparamagnetic iron‐oxide nanoparticles (SPION). The covalent modification of the SPION results in EPI–SPION, a poten...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-01, Vol.11 (2), p.239-247
Hauptverfasser:	Rao, Yue-feng, Chen, Wei, Liang, Xing-guang, Huang, Yong-zhuo, Miao, Jing, Liu, Lin, Lou, Yan, Zhang, Xing-guo, Wang, Ben, Tang, Rui-kang, Chen, Zhong, Lu, Xiao-yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Biocompatible Materials biomedical applications Cancer Cell Line, Tumor drug delivery Drug Delivery Systems epirubicin Epirubicin - administration & dosage Ferric Compounds - administration & dosage Humans Hydrogen-Ion Concentration iron oxide Magnetic fields Mathematical analysis Metal Nanoparticles Nanoparticles Nanotechnology Neoplasms - drug therapy Neoplasms - pathology Skin - metabolism Skin cancer superparamagnetic materials Therapy Tumor Microenvironment Tumors Vectors (mathematics)
Online-Zugang:	Volltext
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