High glucose driven expression of pro-inflammatory cytokine and chemokine genes in lymphocytes: Molecular mechanisms of IL-17 family gene expression

High glucose is an independent risk factor that alters the expression pattern of cytokines/chemokine leading to leukocyte activation in diabetes. Fluctuation of cytokine milieu in lymphocytes may lead to differentiation into a particular subset. Our objectives were to profile high glucose induced in...

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Veröffentlicht in:	Cellular signalling 2014-03, Vol.26 (3), p.528-539
Hauptverfasser:	Kumar, Prabhakaran, Natarajan, Kartiga, Shanmugam, Narkunaraja
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Atherosclerosis - pathology Cell Adhesion - drug effects Chemokine CCL11 - blood Chemokines Cytokines Diabetes Diabetes Mellitus - genetics Gene expression Genes Glucose Glucose - pharmacology Human Umbilical Vein Endothelial Cells - immunology Humans IL-17 Inhibitors Interleukin-17 - biosynthesis Interleukin-17 - blood Interleukin-17 - genetics Interleukin-6 - biosynthesis Interleukin-6 - blood Interleukin-6 - genetics Interleukin-6 - immunology Jurkat Cells - immunology Kinases Lymphocyte Activation - genetics Lymphocytes NF-kappa B - biosynthesis Oxidative Stress - drug effects Promoter Regions, Genetic RNA, Messenger - biosynthesis Sweetening Agents - pharmacology Th17 Cells - cytology Th17 Cells - immunology Transcription Factor AP-1 - biosynthesis
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