Enhanced bone tissue regeneration by antibacterial and osteoinductive silica-HACC-zein composite scaffolds loaded with rhBMP-2

Abstract Next-generation orthopedic implants with both osteoinductivity and antibacterial ability are greatly needed. In the present study, biodegradable rhBMP-2 loaded zein-based scaffolds with a macroporous structure were synthesized, and SBA-15 nanoparticles and hydroxypropyltrimethyl ammonium ch...

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Veröffentlicht in:	Biomaterials 2014-12, Vol.35 (38), p.10033-10045
Hauptverfasser:	Zhou, Panyu, Xia, Yan, Cheng, Xiaosong, Wang, Panfeng, Xie, Yang, Xu, Shuogui
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Ammonium Chloride - administration & dosage Ammonium Chloride - chemistry Animals Anti-Bacterial Agents - administration & dosage Antibacterial Antiinfectives and antibacterials Bacteria Bacterial Physiological Phenomena - drug effects Biocompatibility Biomedical materials Bone Morphogenetic Protein 2 - administration & dosage Bone Morphogenetic Protein 2 - chemistry Bone Regeneration - drug effects Bone Substitutes - administration & dosage Bone tissue engineering Bones Cell Survival - drug effects Chitosan - chemistry Defects Dentistry Drug Implants - administration & dosage Drug Implants - chemistry Equipment Failure Analysis Escherichia coli Humans Mice Nanocomposites - administration & dosage Nanocomposites - chemistry Osteogenesis - drug effects Osteogenesis - physiology Osteoinductive Prosthesis Design Rabbits Radius Fractures - pathology Radius Fractures - therapy Recombinant Proteins - administration & dosage rhBMP-2 Scaffolds Silica-HACC-zein Silicon Dioxide - chemistry Staphylococcus aureus Surgical implants Tissue Scaffolds Treatment Outcome Zein - chemistry
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