Green synthesis of platinum nanoparticles that induce cell death and G2/M-phase cell cycle arrest in human cervical cancer cells
Platinum-based chemotherapeutic drugs, including cisplatin, carboplatin, and oxaliplatin, have been used to manage cancer in spite of dose-dependent side effects, including nephrotoxicity, neurotoxicity and ototoxicity. These disadvantages have prompted the development of new strategies for cancer t...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2015-01, Vol.26 (1), p.5330-9, Article 7 |
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| creator | Alshatwi, Ali A. Athinarayanan, Jegan Vaiyapuri Subbarayan, Periasamy |
| description | Platinum-based chemotherapeutic drugs, including cisplatin, carboplatin, and oxaliplatin, have been used to manage cancer in spite of dose-dependent side effects, including nephrotoxicity, neurotoxicity and ototoxicity. These disadvantages have prompted the development of new strategies for cancer therapy that utilize functionalized nanoparticles as nanomedicines. In the present investigation, we have synthesized platinum nanoparticles using tea polyphenol (TPP) as both a reducing and surface modifying agent. The crystalline nature and morphology of the prepared TPP-functionalized platinum nanoparticles (TPP@Pt) were analyzed using X-ray diffraction (XRD) and transmission electron microscopy (TEM). The XRD results revealed that the TPP@Pt had a crystalline nature with a face-centered cubic structure. TEM imaging suggested that the TTP@Pt are flower shaped with a well-dispersed 30–60 nm-sized TPP@Pt formation. Cervical cancer cells (SiHa) were then treated with different concentrations of TPP@Pt. The effects of TPP@Pt on cell viability, nuclear morphology and cell cycle distribution were investigated. A cell viability assay revealed that the proliferation of SiHa cells was inhibited by TPP@Pt. Propidium iodide nuclear staining indicated that TPP@Pt induced nuclear fragmentation and chromatin condensation. Treatment with TPP@Pt significantly increased the percentage of cells in the G2/M phase, which indicates induced cell cycle arrest in the G2/M phase and an increased number of cells in the subG0 cell death phase. These findings highlight a potential use of TPP@Pt in cervical cancer treatment.
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| doi_str_mv | 10.1007/s10856-014-5330-1 |
| format | Article |
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Graphical Abstract</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-014-5330-1</identifier><identifier>PMID: 25577212</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Biomaterials ; Biomedical engineering ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Cancer ; Cell cycle ; Cell death ; Cell Death - drug effects ; Cell Division - drug effects ; Cell Line, Tumor ; Ceramics ; Cervical cancer ; Chemistry and Materials Science ; Chemotherapy ; Composites ; Crystal structure ; Engineering and Nano-engineering Approaches for Medical Devices ; Female ; G2 Phase - drug effects ; Glass ; Humans ; Materials Science ; Metal Nanoparticles - chemistry ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence ; Morphology ; Nanoparticles ; Nanotechnology ; Natural Materials ; Platinum ; Platinum - chemistry ; Polymer Sciences ; Regenerative Medicine/Tissue Engineering ; Surfaces and Interfaces ; Thin Films ; Transmission electron microscopy ; Uterine Cervical Neoplasms - pathology ; Viability ; X-Ray Diffraction</subject><ispartof>Journal of materials science. Materials in medicine, 2015-01, Vol.26 (1), p.5330-9, Article 7</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-4c3eebbf427404e993380a0a70c505b6b75aa697e0235639c366b0b12b0acd3c3</citedby><cites>FETCH-LOGICAL-c578t-4c3eebbf427404e993380a0a70c505b6b75aa697e0235639c366b0b12b0acd3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-014-5330-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-014-5330-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25577212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alshatwi, Ali A.</creatorcontrib><creatorcontrib>Athinarayanan, Jegan</creatorcontrib><creatorcontrib>Vaiyapuri Subbarayan, Periasamy</creatorcontrib><title>Green synthesis of platinum nanoparticles that induce cell death and G2/M-phase cell cycle arrest in human cervical cancer cells</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Platinum-based chemotherapeutic drugs, including cisplatin, carboplatin, and oxaliplatin, have been used to manage cancer in spite of dose-dependent side effects, including nephrotoxicity, neurotoxicity and ototoxicity. These disadvantages have prompted the development of new strategies for cancer therapy that utilize functionalized nanoparticles as nanomedicines. In the present investigation, we have synthesized platinum nanoparticles using tea polyphenol (TPP) as both a reducing and surface modifying agent. The crystalline nature and morphology of the prepared TPP-functionalized platinum nanoparticles (TPP@Pt) were analyzed using X-ray diffraction (XRD) and transmission electron microscopy (TEM). The XRD results revealed that the TPP@Pt had a crystalline nature with a face-centered cubic structure. TEM imaging suggested that the TTP@Pt are flower shaped with a well-dispersed 30–60 nm-sized TPP@Pt formation. Cervical cancer cells (SiHa) were then treated with different concentrations of TPP@Pt. The effects of TPP@Pt on cell viability, nuclear morphology and cell cycle distribution were investigated. A cell viability assay revealed that the proliferation of SiHa cells was inhibited by TPP@Pt. Propidium iodide nuclear staining indicated that TPP@Pt induced nuclear fragmentation and chromatin condensation. Treatment with TPP@Pt significantly increased the percentage of cells in the G2/M phase, which indicates induced cell cycle arrest in the G2/M phase and an increased number of cells in the subG0 cell death phase. These findings highlight a potential use of TPP@Pt in cervical cancer treatment.
Graphical Abstract</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biomaterials</subject><subject>Biomedical engineering</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cell Death - drug effects</subject><subject>Cell Division - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Ceramics</subject><subject>Cervical cancer</subject><subject>Chemistry and Materials Science</subject><subject>Chemotherapy</subject><subject>Composites</subject><subject>Crystal structure</subject><subject>Engineering and Nano-engineering Approaches for Medical Devices</subject><subject>Female</subject><subject>G2 Phase - drug effects</subject><subject>Glass</subject><subject>Humans</subject><subject>Materials Science</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Microscopy, Electron, Transmission</subject><subject>Microscopy, Fluorescence</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Natural Materials</subject><subject>Platinum</subject><subject>Platinum - chemistry</subject><subject>Polymer Sciences</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Surfaces and Interfaces</subject><subject>Thin Films</subject><subject>Transmission electron microscopy</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Viability</subject><subject>X-Ray Diffraction</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU-L1TAUxYMoznP0A7iRgBs3cW7-t0sZ9Dkw4kbX4TbNsx3atCat8Hbz0U19TxFBmFUunN85uZdDyEsObzmAvcocKm0YcMW0lMD4I7Lj2kqmKlk9JjuotWVKS7ggz3K-AwBVa_2UXAitrRVc7Mj9PoUQaT7GpQu5z3Q60HnApY_rSCPGaca09H4ImS4dLrSP7eoD9WEYaBtw6SjGlu7F1Sc2d5jPij8WB8WUQt4stFtHjEVKP3qPRcZY5l9ofk6eHHDI4cX5vSRfP7z_cv2R3X7e31y_u2Ve22physsQmuaghFWgQl1LWQECWvAadGMaqxFNbQMIqY2svTSmgYaLBtC30stL8uaUO6fp-1r2cmOftw0whmnNjhsDYIyw1QNQrYw1lZQPQJUWorbKFPT1P-jdtKZYbt4oVe6pNC8UP1E-TTmncHBz6kdMR8fBbaW7U-mulO620t3meXVOXpsxtH8cv1sugDgBuUjxW0h_ff3f1J_QFLXz</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Alshatwi, Ali A.</creator><creator>Athinarayanan, Jegan</creator><creator>Vaiyapuri Subbarayan, Periasamy</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0W</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Green synthesis of platinum nanoparticles that induce cell death and G2/M-phase cell cycle arrest in human cervical cancer cells</title><author>Alshatwi, Ali A. ; Athinarayanan, Jegan ; Vaiyapuri Subbarayan, Periasamy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-4c3eebbf427404e993380a0a70c505b6b75aa697e0235639c366b0b12b0acd3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biomaterials</topic><topic>Biomedical engineering</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedical materials</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Cell Death - drug effects</topic><topic>Cell Division - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Ceramics</topic><topic>Cervical cancer</topic><topic>Chemistry and Materials Science</topic><topic>Chemotherapy</topic><topic>Composites</topic><topic>Crystal structure</topic><topic>Engineering and Nano-engineering Approaches for Medical Devices</topic><topic>Female</topic><topic>G2 Phase - drug effects</topic><topic>Glass</topic><topic>Humans</topic><topic>Materials Science</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Microscopy, Electron, Transmission</topic><topic>Microscopy, Fluorescence</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Natural Materials</topic><topic>Platinum</topic><topic>Platinum - chemistry</topic><topic>Polymer Sciences</topic><topic>Regenerative Medicine/Tissue Engineering</topic><topic>Surfaces and Interfaces</topic><topic>Thin Films</topic><topic>Transmission electron microscopy</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Viability</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alshatwi, Ali A.</creatorcontrib><creatorcontrib>Athinarayanan, Jegan</creatorcontrib><creatorcontrib>Vaiyapuri Subbarayan, Periasamy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>DELNET Engineering & Technology Collection</collection><collection>MEDLINE - 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alshatwi, Ali A.</au><au>Athinarayanan, Jegan</au><au>Vaiyapuri Subbarayan, Periasamy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green synthesis of platinum nanoparticles that induce cell death and G2/M-phase cell cycle arrest in human cervical cancer cells</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>26</volume><issue>1</issue><spage>5330</spage><epage>9</epage><pages>5330-9</pages><artnum>7</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Platinum-based chemotherapeutic drugs, including cisplatin, carboplatin, and oxaliplatin, have been used to manage cancer in spite of dose-dependent side effects, including nephrotoxicity, neurotoxicity and ototoxicity. These disadvantages have prompted the development of new strategies for cancer therapy that utilize functionalized nanoparticles as nanomedicines. In the present investigation, we have synthesized platinum nanoparticles using tea polyphenol (TPP) as both a reducing and surface modifying agent. The crystalline nature and morphology of the prepared TPP-functionalized platinum nanoparticles (TPP@Pt) were analyzed using X-ray diffraction (XRD) and transmission electron microscopy (TEM). The XRD results revealed that the TPP@Pt had a crystalline nature with a face-centered cubic structure. TEM imaging suggested that the TTP@Pt are flower shaped with a well-dispersed 30–60 nm-sized TPP@Pt formation. Cervical cancer cells (SiHa) were then treated with different concentrations of TPP@Pt. The effects of TPP@Pt on cell viability, nuclear morphology and cell cycle distribution were investigated. A cell viability assay revealed that the proliferation of SiHa cells was inhibited by TPP@Pt. Propidium iodide nuclear staining indicated that TPP@Pt induced nuclear fragmentation and chromatin condensation. Treatment with TPP@Pt significantly increased the percentage of cells in the G2/M phase, which indicates induced cell cycle arrest in the G2/M phase and an increased number of cells in the subG0 cell death phase. These findings highlight a potential use of TPP@Pt in cervical cancer treatment.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25577212</pmid><doi>10.1007/s10856-014-5330-1</doi><tpages>9</tpages></addata></record> |
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| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biomaterials Biomedical engineering Biomedical Engineering and Bioengineering Biomedical materials Cancer Cell cycle Cell death Cell Death - drug effects Cell Division - drug effects Cell Line, Tumor Ceramics Cervical cancer Chemistry and Materials Science Chemotherapy Composites Crystal structure Engineering and Nano-engineering Approaches for Medical Devices Female G2 Phase - drug effects Glass Humans Materials Science Metal Nanoparticles - chemistry Microscopy, Electron, Transmission Microscopy, Fluorescence Morphology Nanoparticles Nanotechnology Natural Materials Platinum Platinum - chemistry Polymer Sciences Regenerative Medicine/Tissue Engineering Surfaces and Interfaces Thin Films Transmission electron microscopy Uterine Cervical Neoplasms - pathology Viability X-Ray Diffraction |
| title | Green synthesis of platinum nanoparticles that induce cell death and G2/M-phase cell cycle arrest in human cervical cancer cells |
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