Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways

[Display omitted] •Triptolide (TP) has potential toxicity on heart.•Cardiotoxicity of TP involves ROS-mediated mitochondria-dependent apoptosis pathway.•Nrf2 pathway is an important mediator in TP-induced oxidative stress.•Nrf2 may be a promising cardioprotective target against TP-induced cardiac in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology letters 2014-11, Vol.230 (3), p.454-466
Hauptverfasser:	Zhou, Jie, Xi, Chen, Wang, Wenwen, Fu, Xinglu, Jinqiang, Liang, Qiu, Yuwen, Jin, Jin, Xu, Jingfen, Huang, Zhiying
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Biocompatibility Cardiotoxicity Caspase 3 - metabolism Cell Line Cytochromes c - metabolism Diterpenes - toxicity Epoxy Compounds - toxicity In vitro testing Male Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred BALB C Mitochondria - drug effects Mitochondrion Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Oxidative stress Oxidative Stress - drug effects Pathways Phenanthrenes - toxicity Rats Reactive Oxygen Species - metabolism Signal Transduction Stresses Toxicity Triptolide Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!