Study of 1,4-naphthoquinone as a new useful derivatization reagent for LC analysis of aliphatic thiols in dietary supplements and pharmaceuticals

The use of 1,4-naphthoquinone as an advantageous pre-column reagent for liquid chromatography analysis of aliphatic thiol compounds is proposed. The compound reacts selectively in mild conditions (5 min at room temperature; pH 7.5) with thiol function. The resulting adducts were separated under isoc...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2013-01, Vol.405 (2-3), p.817-825
Hauptverfasser:	Gatti, Rita, Andreatta, Paolo, Boschetti, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - chemistry Adducts Aliphatic compounds Amino acids Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Chemical properties Chemical tests and reagents Chemistry Chemistry and Materials Science Chromatography Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Composition Derivatives Dietary supplements Dietary Supplements - analysis Flow rates Food Science Identification and classification Laboratory Medicine Liquid chromatography Mass spectrometry Methods Methyl alcohol Monitoring/Environmental Analysis Naphthoquinones - chemistry Original Paper Oxidative stress Pharmaceutical chemistry Pharmaceutical Preparations - analysis Pharmaceuticals Quinone Reagents Scientific imaging Sulfhydryl Compounds - analysis Sulfur Thiols
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