UPLC-Q-TOF-MS analysis of non-volatile migrants from new active packaging materials
Ultra-performance liquid chromatography (UPLC) coupled to mass spectrometry (MS) is a useful tool in the analysis of non-volatile compounds, and the use of a quadrupole-time-of-flight (Q-TOF) mass analyzer allows a high sensitivity and accuracy when acquiring full fragment mode, providing a high ass...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2012-10, Vol.404 (6-7), p.1945-1957 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Aznar, M. Rodriguez-Lafuente, A. Alfaro, P. Nerin, C. |
| description | Ultra-performance liquid chromatography (UPLC) coupled to mass spectrometry (MS) is a useful tool in the analysis of non-volatile compounds, and the use of a quadrupole-time-of-flight (Q-TOF) mass analyzer allows a high sensitivity and accuracy when acquiring full fragment mode, providing a high assurance of correct identification of unknown compounds. In this work, UPLC-Q-TOF-MS technology has been applied to the analysis of non-volatile migrants from new active packaging materials. The materials tested were based on polypropylene (PP), ethylene–vinyl alcohol copolymer (EVOH), and poly(ethylene terephthalate) (PET). The active packaging materials studied were one PP film containing a natural antioxidant, and two PP/EVOH films, two PET/EVOH films and one coextruded PP/EVOH/PP film containing natural antimicrobials. The chemical structure of several compounds was unequivocally identified. The analysis revealed the migration of some of the active substances used in the manufacture of active packaging, such as caffeine (0.07 ± 0.01 μg/g), carvacrol (0.31 ± 0.03 μg/g) and citral (0.20 ± 0.01 μg/g). Unintentionally added substances were also found, such as citral reaction compounds, or citral impurities present in the raw materials. |
| doi_str_mv | 10.1007/s00216-012-6247-5 |
| format | Article |
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In this work, UPLC-Q-TOF-MS technology has been applied to the analysis of non-volatile migrants from new active packaging materials. The materials tested were based on polypropylene (PP), ethylene–vinyl alcohol copolymer (EVOH), and poly(ethylene terephthalate) (PET). The active packaging materials studied were one PP film containing a natural antioxidant, and two PP/EVOH films, two PET/EVOH films and one coextruded PP/EVOH/PP film containing natural antimicrobials. The chemical structure of several compounds was unequivocally identified. The analysis revealed the migration of some of the active substances used in the manufacture of active packaging, such as caffeine (0.07 ± 0.01 μg/g), carvacrol (0.31 ± 0.03 μg/g) and citral (0.20 ± 0.01 μg/g). Unintentionally added substances were also found, such as citral reaction compounds, or citral impurities present in the raw materials.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-012-6247-5</identifier><identifier>PMID: 22836481</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Alcohols ; Analysis ; Analytical Chemistry ; Anti-Infective Agents - analysis ; Antioxidants - analysis ; Biochemistry ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chromatography, High Pressure Liquid - methods ; Citral ; Food ; Food Contamination - analysis ; Food Packaging - instrumentation ; Food Science ; Laboratory Medicine ; Liquid chromatography ; Mass Spectrometry - methods ; Monitoring/Environmental Analysis ; Original Paper ; Packaging ; Polyethylene terephthalates ; Polypropylenes ; Polypropylenes - analysis ; Polyvinyls - analysis ; Raw materials ; Time-of-flight mass spectrometry</subject><ispartof>Analytical and bioanalytical chemistry, 2012-10, Vol.404 (6-7), p.1945-1957</ispartof><rights>Springer-Verlag 2012</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-d3b856058e06d0210363baedd7bba060c9289a9ccfacddd57f1d5c573e953fc23</citedby><cites>FETCH-LOGICAL-c486t-d3b856058e06d0210363baedd7bba060c9289a9ccfacddd57f1d5c573e953fc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-012-6247-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-012-6247-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22836481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aznar, M.</creatorcontrib><creatorcontrib>Rodriguez-Lafuente, A.</creatorcontrib><creatorcontrib>Alfaro, P.</creatorcontrib><creatorcontrib>Nerin, C.</creatorcontrib><title>UPLC-Q-TOF-MS analysis of non-volatile migrants from new active packaging materials</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Ultra-performance liquid chromatography (UPLC) coupled to mass spectrometry (MS) is a useful tool in the analysis of non-volatile compounds, and the use of a quadrupole-time-of-flight (Q-TOF) mass analyzer allows a high sensitivity and accuracy when acquiring full fragment mode, providing a high assurance of correct identification of unknown compounds. In this work, UPLC-Q-TOF-MS technology has been applied to the analysis of non-volatile migrants from new active packaging materials. The materials tested were based on polypropylene (PP), ethylene–vinyl alcohol copolymer (EVOH), and poly(ethylene terephthalate) (PET). The active packaging materials studied were one PP film containing a natural antioxidant, and two PP/EVOH films, two PET/EVOH films and one coextruded PP/EVOH/PP film containing natural antimicrobials. The chemical structure of several compounds was unequivocally identified. The analysis revealed the migration of some of the active substances used in the manufacture of active packaging, such as caffeine (0.07 ± 0.01 μg/g), carvacrol (0.31 ± 0.03 μg/g) and citral (0.20 ± 0.01 μg/g). Unintentionally added substances were also found, such as citral reaction compounds, or citral impurities present in the raw materials.</description><subject>Alcohols</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Anti-Infective Agents - analysis</subject><subject>Antioxidants - analysis</subject><subject>Biochemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Citral</subject><subject>Food</subject><subject>Food Contamination - analysis</subject><subject>Food Packaging - instrumentation</subject><subject>Food Science</subject><subject>Laboratory Medicine</subject><subject>Liquid chromatography</subject><subject>Mass Spectrometry - methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Original Paper</subject><subject>Packaging</subject><subject>Polyethylene terephthalates</subject><subject>Polypropylenes</subject><subject>Polypropylenes - analysis</subject><subject>Polyvinyls - analysis</subject><subject>Raw materials</subject><subject>Time-of-flight mass spectrometry</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuFSEUhomxsbX6AG4MSzfUAwwMs2xurDW5pjZt14QBZkKdgSvMrenbl5upXVpYHBK-c_LDh9AnCmcUoP1aABiVBCgjkjUtEW_QCZVUESYFvH05N-wYvS_lHoAKReU7dMyY4rJR9ATd3P3absg1ub26ID9vsIlmeiyh4DTgmCJ5SJNZwuTxHMZs4lLwkNOMo_-LjV3Cg8c7Y3-bMcQRz2bxOZipfEBHQy3-43M9RXcX3243l2R79f3H5nxLbKPkQhzvlZAglAfp6kOAS94b71zb9wYk2I6pznTWDsY650Q7UCesaLnvBB8s46foyzp3l9OfvS-LnkOxfppM9GlfNJUSQHDo5OtowzrVQivhdbSumps3B_RsRUczeR3ikJZsbN3Oz8Gm6If6dfqcdw2lneKHxHRtsDmVkv2gdznMJj9qCvqgVK9KdVWqD0q1qD2fn_Ps-9m7l45_DivAVqDUqzj6rO_TPleR5T9TnwCQH6nV</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Aznar, M.</creator><creator>Rodriguez-Lafuente, A.</creator><creator>Alfaro, P.</creator><creator>Nerin, C.</creator><general>Springer-Verlag</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QH</scope><scope>7UA</scope><scope>C1K</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20121001</creationdate><title>UPLC-Q-TOF-MS analysis of non-volatile migrants from new active packaging materials</title><author>Aznar, M. ; Rodriguez-Lafuente, A. ; Alfaro, P. ; Nerin, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-d3b856058e06d0210363baedd7bba060c9289a9ccfacddd57f1d5c573e953fc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alcohols</topic><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Anti-Infective Agents - analysis</topic><topic>Antioxidants - analysis</topic><topic>Biochemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Citral</topic><topic>Food</topic><topic>Food Contamination - analysis</topic><topic>Food Packaging - instrumentation</topic><topic>Food Science</topic><topic>Laboratory Medicine</topic><topic>Liquid chromatography</topic><topic>Mass Spectrometry - methods</topic><topic>Monitoring/Environmental Analysis</topic><topic>Original Paper</topic><topic>Packaging</topic><topic>Polyethylene terephthalates</topic><topic>Polypropylenes</topic><topic>Polypropylenes - analysis</topic><topic>Polyvinyls - analysis</topic><topic>Raw materials</topic><topic>Time-of-flight mass spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aznar, M.</creatorcontrib><creatorcontrib>Rodriguez-Lafuente, A.</creatorcontrib><creatorcontrib>Alfaro, P.</creatorcontrib><creatorcontrib>Nerin, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aznar, M.</au><au>Rodriguez-Lafuente, A.</au><au>Alfaro, P.</au><au>Nerin, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UPLC-Q-TOF-MS analysis of non-volatile migrants from new active packaging materials</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>404</volume><issue>6-7</issue><spage>1945</spage><epage>1957</epage><pages>1945-1957</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Ultra-performance liquid chromatography (UPLC) coupled to mass spectrometry (MS) is a useful tool in the analysis of non-volatile compounds, and the use of a quadrupole-time-of-flight (Q-TOF) mass analyzer allows a high sensitivity and accuracy when acquiring full fragment mode, providing a high assurance of correct identification of unknown compounds. In this work, UPLC-Q-TOF-MS technology has been applied to the analysis of non-volatile migrants from new active packaging materials. The materials tested were based on polypropylene (PP), ethylene–vinyl alcohol copolymer (EVOH), and poly(ethylene terephthalate) (PET). The active packaging materials studied were one PP film containing a natural antioxidant, and two PP/EVOH films, two PET/EVOH films and one coextruded PP/EVOH/PP film containing natural antimicrobials. The chemical structure of several compounds was unequivocally identified. The analysis revealed the migration of some of the active substances used in the manufacture of active packaging, such as caffeine (0.07 ± 0.01 μg/g), carvacrol (0.31 ± 0.03 μg/g) and citral (0.20 ± 0.01 μg/g). 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| subjects | Alcohols Analysis Analytical Chemistry Anti-Infective Agents - analysis Antioxidants - analysis Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography, High Pressure Liquid - methods Citral Food Food Contamination - analysis Food Packaging - instrumentation Food Science Laboratory Medicine Liquid chromatography Mass Spectrometry - methods Monitoring/Environmental Analysis Original Paper Packaging Polyethylene terephthalates Polypropylenes Polypropylenes - analysis Polyvinyls - analysis Raw materials Time-of-flight mass spectrometry |
| title | UPLC-Q-TOF-MS analysis of non-volatile migrants from new active packaging materials |
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