Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice

[Display omitted] ► Heme oxygenase-1 negatively regulated high mobility group box 1 in inflammation. ► Demonstration of a role for p38 MAPK/Nrf2 signal for induction of heme oxygenase-1. ► Inula helenium L. maybe useful for treatment of sepsis.. High mobility group box 1 (HMGB1) plays a crucial medi...

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Veröffentlicht in:	Food and chemical toxicology 2013-05, Vol.55, p.386-395
Hauptverfasser:	Park, Eun Jung, Kim, Young Min, Park, Sang Won, Kim, Hye Jung, Lee, Jae Heun, Lee, Dong-Ung, Chang, Ki Churl
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine transaminase Animals anti-inflammatory activity aspartate transaminase Biological and medical sciences blood Cell Line creatinine Diseases Enzyme Induction Ethanol Ethanol - chemistry Ethyl alcohol General pharmacology heme oxygenase (biliverdin-producing) Heme Oxygenase-1 - biosynthesis HMGB1 HO-1 human umbilical vein endothelial cells IKappaB kinase inducible nitric oxide synthase Inflammation Inflammation - enzymology Inflammation - metabolism Inflammation - prevention & control Inhibitors Inula - chemistry Inula helenium Lipopolysaccharides - pharmacology liver luciferase macrophages Medical sciences Mice Multiple organ failure NF-E2-Related Factor 2 - metabolism nitric oxide p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism pathogenesis Pathways Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phosphorylation Plant Extracts - pharmacology Sepsis - enzymology Sepsis - metabolism Sepsis - physiopathology Signal Transduction Toxicology transcription factor NF-kappa B transfection tumor necrosis factor-alpha Veins
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