Recent methodological advances in MALDI mass spectrometry
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used for characterization of large, thermally labile biomolecules. Advantages of this analytical technique are high sensitivity, robustness, high-throughput capacity, and applicability to a wide range of compound clas...
Gespeichert in:
| Veröffentlicht in: | Analytical and bioanalytical chemistry 2014-04, Vol.406 (9-10), p.2261-2278 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2278 |
|---|---|
| container_issue | 9-10 |
| container_start_page | 2261 |
| container_title | Analytical and bioanalytical chemistry |
| container_volume | 406 |
| creator | Dreisewerd, Klaus |
| description | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used for characterization of large, thermally labile biomolecules. Advantages of this analytical technique are high sensitivity, robustness, high-throughput capacity, and applicability to a wide range of compound classes. For some years, MALDI-MS has also been increasingly used for mass spectrometric imaging as well as in other areas of clinical research. Recently, several new concepts have been presented that have the potential to further advance the performance characteristics of MALDI. Among these innovations are novel matrices with low proton affinities for particularly efficient protonation of analyte molecules, use of wavelength-tunable lasers to achieve optimum excitation conditions, and use of liquid matrices for improved quantification. Instrumental modifications have also made possible MALDI-MS imaging with cellular resolution as well as an efficient generation of multiply charged MALDI ions by use of heated vacuum interfaces. This article reviews these recent innovations and gives the author’s personal outlook of possible future developments.
Figure
Figure published in Cramer, RC, Dreisewerd, K. (2007) UV Matrix‐Assisted Laser Desorption/Ionization: Principles, Instrumentation, and Applications. In: M. Gross (Ed.): Encyclopedia of Mass Spectrometry, Vol. 6, pp 646‐661, Elsevier, Oxford |
| doi_str_mv | 10.1007/s00216-014-7646-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660048039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A387257730</galeid><sourcerecordid>A387257730</sourcerecordid><originalsourceid>FETCH-LOGICAL-c580t-950e896f7dfcb5ebead497c3448874f3f7e84ad9d456659ed0be7d60acff6d233</originalsourceid><addsrcrecordid>eNqNkdFrFDEQxhdRbK3-Ab7Igi--bDvZTSbJ41G1Fq4IpT6HXDI5t-xuzmSv0P_eXLcWEUTJQ8Lk9818w1dVbxmcMgB5lgFahg0w3kjk2OCz6pghU02LAp4_vXl7VL3K-RaACcXwZXXUchQt43hc6WtyNM31SPP36OMQt72zQ239nZ0c5bqf6qvV-uNlPdqc67wjN6dY4HT_unoR7JDpzeN9Un37_Onm_Euz_npxeb5aN04omBstgJTGIH1wG0Ebsp5r6TrOlZI8dEGS4tZrzwWi0ORhQ9IjWBcC-rbrTqoPS99dij_2lGcz9tnRMNiJ4j4bhgjAFXT636gQWjIFKP8DZazTCh_Q93-gt3GfprJzmS2hlULIg83ThdragUw_hTgn68rxNPYuThT6Ul91SrZCyg6KgC0Cl2LOiYLZpX606d4wMId4zRKvKfGaQ7wGi-bdo5X9ZiT_pPiVZwHaBcjla9pS-s3rX7v-BM-NrQ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1670275573</pqid></control><display><type>article</type><title>Recent methodological advances in MALDI mass spectrometry</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Dreisewerd, Klaus</creator><creatorcontrib>Dreisewerd, Klaus</creatorcontrib><description>Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used for characterization of large, thermally labile biomolecules. Advantages of this analytical technique are high sensitivity, robustness, high-throughput capacity, and applicability to a wide range of compound classes. For some years, MALDI-MS has also been increasingly used for mass spectrometric imaging as well as in other areas of clinical research. Recently, several new concepts have been presented that have the potential to further advance the performance characteristics of MALDI. Among these innovations are novel matrices with low proton affinities for particularly efficient protonation of analyte molecules, use of wavelength-tunable lasers to achieve optimum excitation conditions, and use of liquid matrices for improved quantification. Instrumental modifications have also made possible MALDI-MS imaging with cellular resolution as well as an efficient generation of multiply charged MALDI ions by use of heated vacuum interfaces. This article reviews these recent innovations and gives the author’s personal outlook of possible future developments.
Figure
Figure published in Cramer, RC, Dreisewerd, K. (2007) UV Matrix‐Assisted Laser Desorption/Ionization: Principles, Instrumentation, and Applications. In: M. Gross (Ed.): Encyclopedia of Mass Spectrometry, Vol. 6, pp 646‐661, Elsevier, Oxford</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-014-7646-6</identifier><identifier>PMID: 24652146</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acids ; Analysis ; Analytical Chemistry ; Animals ; Biochemistry ; Bisphenol A ; Characterization and Evaluation of Materials ; Charging ; Chemistry ; Chemistry and Materials Science ; Food Science ; Humans ; Imaging ; Innovations ; Ionization ; Laboratory Medicine ; Lasers ; Lipids ; Liquids ; Mass spectrometry ; Mathematical analysis ; Monitoring/Environmental Analysis ; Optimization ; Peptides ; Peptides - chemistry ; Proteins ; Proteins - chemistry ; Review ; Robustness ; Scientific imaging ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends ; Trace elements</subject><ispartof>Analytical and bioanalytical chemistry, 2014-04, Vol.406 (9-10), p.2261-2278</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-950e896f7dfcb5ebead497c3448874f3f7e84ad9d456659ed0be7d60acff6d233</citedby><cites>FETCH-LOGICAL-c580t-950e896f7dfcb5ebead497c3448874f3f7e84ad9d456659ed0be7d60acff6d233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-014-7646-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-014-7646-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24652146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dreisewerd, Klaus</creatorcontrib><title>Recent methodological advances in MALDI mass spectrometry</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used for characterization of large, thermally labile biomolecules. Advantages of this analytical technique are high sensitivity, robustness, high-throughput capacity, and applicability to a wide range of compound classes. For some years, MALDI-MS has also been increasingly used for mass spectrometric imaging as well as in other areas of clinical research. Recently, several new concepts have been presented that have the potential to further advance the performance characteristics of MALDI. Among these innovations are novel matrices with low proton affinities for particularly efficient protonation of analyte molecules, use of wavelength-tunable lasers to achieve optimum excitation conditions, and use of liquid matrices for improved quantification. Instrumental modifications have also made possible MALDI-MS imaging with cellular resolution as well as an efficient generation of multiply charged MALDI ions by use of heated vacuum interfaces. This article reviews these recent innovations and gives the author’s personal outlook of possible future developments.
Figure
Figure published in Cramer, RC, Dreisewerd, K. (2007) UV Matrix‐Assisted Laser Desorption/Ionization: Principles, Instrumentation, and Applications. In: M. Gross (Ed.): Encyclopedia of Mass Spectrometry, Vol. 6, pp 646‐661, Elsevier, Oxford</description><subject>Acids</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Bisphenol A</subject><subject>Characterization and Evaluation of Materials</subject><subject>Charging</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Food Science</subject><subject>Humans</subject><subject>Imaging</subject><subject>Innovations</subject><subject>Ionization</subject><subject>Laboratory Medicine</subject><subject>Lasers</subject><subject>Lipids</subject><subject>Liquids</subject><subject>Mass spectrometry</subject><subject>Mathematical analysis</subject><subject>Monitoring/Environmental Analysis</subject><subject>Optimization</subject><subject>Peptides</subject><subject>Peptides - chemistry</subject><subject>Proteins</subject><subject>Proteins - chemistry</subject><subject>Review</subject><subject>Robustness</subject><subject>Scientific imaging</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends</subject><subject>Trace elements</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkdFrFDEQxhdRbK3-Ab7Igi--bDvZTSbJ41G1Fq4IpT6HXDI5t-xuzmSv0P_eXLcWEUTJQ8Lk9818w1dVbxmcMgB5lgFahg0w3kjk2OCz6pghU02LAp4_vXl7VL3K-RaACcXwZXXUchQt43hc6WtyNM31SPP36OMQt72zQ239nZ0c5bqf6qvV-uNlPdqc67wjN6dY4HT_unoR7JDpzeN9Un37_Onm_Euz_npxeb5aN04omBstgJTGIH1wG0Ebsp5r6TrOlZI8dEGS4tZrzwWi0ORhQ9IjWBcC-rbrTqoPS99dij_2lGcz9tnRMNiJ4j4bhgjAFXT636gQWjIFKP8DZazTCh_Q93-gt3GfprJzmS2hlULIg83ThdragUw_hTgn68rxNPYuThT6Ul91SrZCyg6KgC0Cl2LOiYLZpX606d4wMId4zRKvKfGaQ7wGi-bdo5X9ZiT_pPiVZwHaBcjla9pS-s3rX7v-BM-NrQ4</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Dreisewerd, Klaus</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7QH</scope><scope>7UA</scope></search><sort><creationdate>20140401</creationdate><title>Recent methodological advances in MALDI mass spectrometry</title><author>Dreisewerd, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-950e896f7dfcb5ebead497c3448874f3f7e84ad9d456659ed0be7d60acff6d233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acids</topic><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Bisphenol A</topic><topic>Characterization and Evaluation of Materials</topic><topic>Charging</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Food Science</topic><topic>Humans</topic><topic>Imaging</topic><topic>Innovations</topic><topic>Ionization</topic><topic>Laboratory Medicine</topic><topic>Lasers</topic><topic>Lipids</topic><topic>Liquids</topic><topic>Mass spectrometry</topic><topic>Mathematical analysis</topic><topic>Monitoring/Environmental Analysis</topic><topic>Optimization</topic><topic>Peptides</topic><topic>Peptides - chemistry</topic><topic>Proteins</topic><topic>Proteins - chemistry</topic><topic>Review</topic><topic>Robustness</topic><topic>Scientific imaging</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends</topic><topic>Trace elements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dreisewerd, Klaus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dreisewerd, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent methodological advances in MALDI mass spectrometry</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>406</volume><issue>9-10</issue><spage>2261</spage><epage>2278</epage><pages>2261-2278</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used for characterization of large, thermally labile biomolecules. Advantages of this analytical technique are high sensitivity, robustness, high-throughput capacity, and applicability to a wide range of compound classes. For some years, MALDI-MS has also been increasingly used for mass spectrometric imaging as well as in other areas of clinical research. Recently, several new concepts have been presented that have the potential to further advance the performance characteristics of MALDI. Among these innovations are novel matrices with low proton affinities for particularly efficient protonation of analyte molecules, use of wavelength-tunable lasers to achieve optimum excitation conditions, and use of liquid matrices for improved quantification. Instrumental modifications have also made possible MALDI-MS imaging with cellular resolution as well as an efficient generation of multiply charged MALDI ions by use of heated vacuum interfaces. This article reviews these recent innovations and gives the author’s personal outlook of possible future developments.
Figure
Figure published in Cramer, RC, Dreisewerd, K. (2007) UV Matrix‐Assisted Laser Desorption/Ionization: Principles, Instrumentation, and Applications. In: M. Gross (Ed.): Encyclopedia of Mass Spectrometry, Vol. 6, pp 646‐661, Elsevier, Oxford</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24652146</pmid><doi>10.1007/s00216-014-7646-6</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1618-2642 |
| ispartof | Analytical and bioanalytical chemistry, 2014-04, Vol.406 (9-10), p.2261-2278 |
| issn | 1618-2642 1618-2650 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1660048039 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acids Analysis Analytical Chemistry Animals Biochemistry Bisphenol A Characterization and Evaluation of Materials Charging Chemistry Chemistry and Materials Science Food Science Humans Imaging Innovations Ionization Laboratory Medicine Lasers Lipids Liquids Mass spectrometry Mathematical analysis Monitoring/Environmental Analysis Optimization Peptides Peptides - chemistry Proteins Proteins - chemistry Review Robustness Scientific imaging Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends Trace elements |
| title | Recent methodological advances in MALDI mass spectrometry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T03%3A29%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recent%20methodological%20advances%20in%20MALDI%20mass%20spectrometry&rft.jtitle=Analytical%20and%20bioanalytical%20chemistry&rft.au=Dreisewerd,%20Klaus&rft.date=2014-04-01&rft.volume=406&rft.issue=9-10&rft.spage=2261&rft.epage=2278&rft.pages=2261-2278&rft.issn=1618-2642&rft.eissn=1618-2650&rft_id=info:doi/10.1007/s00216-014-7646-6&rft_dat=%3Cgale_proqu%3EA387257730%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1670275573&rft_id=info:pmid/24652146&rft_galeid=A387257730&rfr_iscdi=true |