Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study
BACKGROUND The health‐promoting properties of apples are directly related to the biologically active compounds that they contain, such as polyphenols. The objective of this study was to prepare a low‐sugar, fibre‐ and phlorizin‐enriched powder from unripe apples and to gain insight regarding its ant...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2015-02, Vol.95 (3), p.560-568 |
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| container_title | Journal of the science of food and agriculture |
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| creator | Makarova, Elina Górnaś, Paweł Konrade, Ilze Tirzite, Dace Cirule, Helena Gulbe, Anita Pugajeva, Iveta Seglina, Dalija Dambrova, Maija |
| description | BACKGROUND
The health‐promoting properties of apples are directly related to the biologically active compounds that they contain, such as polyphenols. The objective of this study was to prepare a low‐sugar, fibre‐ and phlorizin‐enriched powder from unripe apples and to gain insight regarding its anti‐hyperglycaemic activity in healthy volunteers.
RESULTS
The unripe apples (Malus domestica Borkh.) were collected 30 days after the full bloom day; blanched and pressed to obtain apple pomace which was then processed with a food cutter, oven‐dried and milled to prepare apple powder. The concentrations of total sugars, water‐soluble pectin and phlorizin in the apple preparation were 153.44 ± 2.46, 27.73 ± 0.51 and 12.61 ± 0.15 g kg−1, respectively. Acute ingestion of the apple preparation improved glucose metabolism in the oral glucose tolerance test (OGTT) in six healthy volunteers by reducing the postprandial glucose response at 15 to 30 min by approximately two‐fold (P < 0.05) and by increasing urinary glucose excretion during the 2‐ to 4‐h interval of the OGTT by five‐fold (P < 0.05).
CONCLUSION
The results obtained indicate that the dried and powdered pomace of unripe apples can be used as a health‐promoting natural product for the reduction of postprandial glycaemia and to improve the health of patients with diabetes. © 2014 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.6779 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660038723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3565188411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5609-d3faf93d406e7a4ab61fb7d7953815b56c03fb87c587ba2430789130c84f51a43</originalsourceid><addsrcrecordid>eNqN0U9vFCEYBnBiNHa7evALGBIv9jAtDDDMeFsbu9U01cR_SS-EYaHLyjAjMOp48qPLZNceTExMSDjwex8CDwBPMDrFCJVnu2jkacV5cw8sMGp4gRBG98Ein5UFw7Q8Ascx7hBCTVNVD8FRSRvMGeML8GulxqSh9MkW22nQ4dZNSurOKqiN0SpF2Jt8DEcf7JDhMDgNh6AHGWSyvYeq90lab_0tHLauD_an9TCvrZYubSf4rXejT1qH-ALKedLZznoZJhjTuJkegQdGuqgfH_Yl-Hjx6sP5ZXH1dv36fHVVKFahptgQI01DNhRVmksq2wqblm94w0iNWcsqhYhpa65YzVtZUoJ43WCCVE0Nw5KSJXi-zx1C_3XUMYnORqWdk173YxS4qhAiNS_Jf1DKeF2SfPcSPPuL7vox-PyQWXGKCKJ1Vid7pUIfY9BGDMF2-QsERmJuUMwNirnBbJ8eEse205s7-aeyDM724Lt1evp3knjz_mJ1iCz2EzYm_eNuQoYvGRLOxOfrtaCfXq5v3l3fiEvyGxsLtkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1647403048</pqid></control><display><type>article</type><title>Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Makarova, Elina ; Górnaś, Paweł ; Konrade, Ilze ; Tirzite, Dace ; Cirule, Helena ; Gulbe, Anita ; Pugajeva, Iveta ; Seglina, Dalija ; Dambrova, Maija</creator><creatorcontrib>Makarova, Elina ; Górnaś, Paweł ; Konrade, Ilze ; Tirzite, Dace ; Cirule, Helena ; Gulbe, Anita ; Pugajeva, Iveta ; Seglina, Dalija ; Dambrova, Maija</creatorcontrib><description>BACKGROUND
The health‐promoting properties of apples are directly related to the biologically active compounds that they contain, such as polyphenols. The objective of this study was to prepare a low‐sugar, fibre‐ and phlorizin‐enriched powder from unripe apples and to gain insight regarding its anti‐hyperglycaemic activity in healthy volunteers.
RESULTS
The unripe apples (Malus domestica Borkh.) were collected 30 days after the full bloom day; blanched and pressed to obtain apple pomace which was then processed with a food cutter, oven‐dried and milled to prepare apple powder. The concentrations of total sugars, water‐soluble pectin and phlorizin in the apple preparation were 153.44 ± 2.46, 27.73 ± 0.51 and 12.61 ± 0.15 g kg−1, respectively. Acute ingestion of the apple preparation improved glucose metabolism in the oral glucose tolerance test (OGTT) in six healthy volunteers by reducing the postprandial glucose response at 15 to 30 min by approximately two‐fold (P < 0.05) and by increasing urinary glucose excretion during the 2‐ to 4‐h interval of the OGTT by five‐fold (P < 0.05).
CONCLUSION
The results obtained indicate that the dried and powdered pomace of unripe apples can be used as a health‐promoting natural product for the reduction of postprandial glycaemia and to improve the health of patients with diabetes. © 2014 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.6779</identifier><identifier>PMID: 24917557</identifier><identifier>CODEN: JSFAAE</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Antioxidants ; Apples ; Blood Glucose - metabolism ; Blooming mills ; Chemical industries ; Cutters ; Diabetes ; Dietary Fiber - analysis ; Dietary Fiber - pharmacology ; Dietary Sucrose - analysis ; Dietary Sucrose - metabolism ; Female ; fibre ; Foods ; Fruit - chemistry ; Glucose ; glucose excretion ; Glucose Tolerance Test ; Healthy Volunteers ; Humans ; Hyperglycemia ; Hyperglycemia - blood ; Hyperglycemia - drug therapy ; Hypoglycemic Agents - analysis ; Hypoglycemic Agents - pharmacology ; Ingestion ; Malus - chemistry ; Metabolism ; Nutrition research ; Patients ; Pectins - analysis ; Pectins - pharmacology ; Phlorhizin - analysis ; Phlorhizin - pharmacology ; phlorizin ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polyphenols ; Polyphenols - pharmacology ; Postprandial Period ; Powders ; Reference Values ; unripe apples</subject><ispartof>Journal of the science of food and agriculture, 2015-02, Vol.95 (3), p.560-568</ispartof><rights>2014 Society of Chemical Industry</rights><rights>2014 Society of Chemical Industry.</rights><rights>Copyright John Wiley and Sons, Limited Feb 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5609-d3faf93d406e7a4ab61fb7d7953815b56c03fb87c587ba2430789130c84f51a43</citedby><cites>FETCH-LOGICAL-c5609-d3faf93d406e7a4ab61fb7d7953815b56c03fb87c587ba2430789130c84f51a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.6779$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.6779$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24917557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Makarova, Elina</creatorcontrib><creatorcontrib>Górnaś, Paweł</creatorcontrib><creatorcontrib>Konrade, Ilze</creatorcontrib><creatorcontrib>Tirzite, Dace</creatorcontrib><creatorcontrib>Cirule, Helena</creatorcontrib><creatorcontrib>Gulbe, Anita</creatorcontrib><creatorcontrib>Pugajeva, Iveta</creatorcontrib><creatorcontrib>Seglina, Dalija</creatorcontrib><creatorcontrib>Dambrova, Maija</creatorcontrib><title>Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>BACKGROUND
The health‐promoting properties of apples are directly related to the biologically active compounds that they contain, such as polyphenols. The objective of this study was to prepare a low‐sugar, fibre‐ and phlorizin‐enriched powder from unripe apples and to gain insight regarding its anti‐hyperglycaemic activity in healthy volunteers.
RESULTS
The unripe apples (Malus domestica Borkh.) were collected 30 days after the full bloom day; blanched and pressed to obtain apple pomace which was then processed with a food cutter, oven‐dried and milled to prepare apple powder. The concentrations of total sugars, water‐soluble pectin and phlorizin in the apple preparation were 153.44 ± 2.46, 27.73 ± 0.51 and 12.61 ± 0.15 g kg−1, respectively. Acute ingestion of the apple preparation improved glucose metabolism in the oral glucose tolerance test (OGTT) in six healthy volunteers by reducing the postprandial glucose response at 15 to 30 min by approximately two‐fold (P < 0.05) and by increasing urinary glucose excretion during the 2‐ to 4‐h interval of the OGTT by five‐fold (P < 0.05).
CONCLUSION
The results obtained indicate that the dried and powdered pomace of unripe apples can be used as a health‐promoting natural product for the reduction of postprandial glycaemia and to improve the health of patients with diabetes. © 2014 Society of Chemical Industry</description><subject>Antioxidants</subject><subject>Apples</subject><subject>Blood Glucose - metabolism</subject><subject>Blooming mills</subject><subject>Chemical industries</subject><subject>Cutters</subject><subject>Diabetes</subject><subject>Dietary Fiber - analysis</subject><subject>Dietary Fiber - pharmacology</subject><subject>Dietary Sucrose - analysis</subject><subject>Dietary Sucrose - metabolism</subject><subject>Female</subject><subject>fibre</subject><subject>Foods</subject><subject>Fruit - chemistry</subject><subject>Glucose</subject><subject>glucose excretion</subject><subject>Glucose Tolerance Test</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - blood</subject><subject>Hyperglycemia - drug therapy</subject><subject>Hypoglycemic Agents - analysis</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Ingestion</subject><subject>Malus - chemistry</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Patients</subject><subject>Pectins - analysis</subject><subject>Pectins - pharmacology</subject><subject>Phlorhizin - analysis</subject><subject>Phlorhizin - pharmacology</subject><subject>phlorizin</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>Polyphenols - pharmacology</subject><subject>Postprandial Period</subject><subject>Powders</subject><subject>Reference Values</subject><subject>unripe apples</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U9vFCEYBnBiNHa7evALGBIv9jAtDDDMeFsbu9U01cR_SS-EYaHLyjAjMOp48qPLZNceTExMSDjwex8CDwBPMDrFCJVnu2jkacV5cw8sMGp4gRBG98Ein5UFw7Q8Ascx7hBCTVNVD8FRSRvMGeML8GulxqSh9MkW22nQ4dZNSurOKqiN0SpF2Jt8DEcf7JDhMDgNh6AHGWSyvYeq90lab_0tHLauD_an9TCvrZYubSf4rXejT1qH-ALKedLZznoZJhjTuJkegQdGuqgfH_Yl-Hjx6sP5ZXH1dv36fHVVKFahptgQI01DNhRVmksq2wqblm94w0iNWcsqhYhpa65YzVtZUoJ43WCCVE0Nw5KSJXi-zx1C_3XUMYnORqWdk173YxS4qhAiNS_Jf1DKeF2SfPcSPPuL7vox-PyQWXGKCKJ1Vid7pUIfY9BGDMF2-QsERmJuUMwNirnBbJ8eEse205s7-aeyDM724Lt1evp3knjz_mJ1iCz2EzYm_eNuQoYvGRLOxOfrtaCfXq5v3l3fiEvyGxsLtkA</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Makarova, Elina</creator><creator>Górnaś, Paweł</creator><creator>Konrade, Ilze</creator><creator>Tirzite, Dace</creator><creator>Cirule, Helena</creator><creator>Gulbe, Anita</creator><creator>Pugajeva, Iveta</creator><creator>Seglina, Dalija</creator><creator>Dambrova, Maija</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study</title><author>Makarova, Elina ; Górnaś, Paweł ; Konrade, Ilze ; Tirzite, Dace ; Cirule, Helena ; Gulbe, Anita ; Pugajeva, Iveta ; Seglina, Dalija ; Dambrova, Maija</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5609-d3faf93d406e7a4ab61fb7d7953815b56c03fb87c587ba2430789130c84f51a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antioxidants</topic><topic>Apples</topic><topic>Blood Glucose - metabolism</topic><topic>Blooming mills</topic><topic>Chemical industries</topic><topic>Cutters</topic><topic>Diabetes</topic><topic>Dietary Fiber - analysis</topic><topic>Dietary Fiber - pharmacology</topic><topic>Dietary Sucrose - analysis</topic><topic>Dietary Sucrose - metabolism</topic><topic>Female</topic><topic>fibre</topic><topic>Foods</topic><topic>Fruit - chemistry</topic><topic>Glucose</topic><topic>glucose excretion</topic><topic>Glucose Tolerance Test</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - blood</topic><topic>Hyperglycemia - drug therapy</topic><topic>Hypoglycemic Agents - analysis</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Ingestion</topic><topic>Malus - chemistry</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>Patients</topic><topic>Pectins - analysis</topic><topic>Pectins - pharmacology</topic><topic>Phlorhizin - analysis</topic><topic>Phlorhizin - pharmacology</topic><topic>phlorizin</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyphenols</topic><topic>Polyphenols - pharmacology</topic><topic>Postprandial Period</topic><topic>Powders</topic><topic>Reference Values</topic><topic>unripe apples</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Makarova, Elina</creatorcontrib><creatorcontrib>Górnaś, Paweł</creatorcontrib><creatorcontrib>Konrade, Ilze</creatorcontrib><creatorcontrib>Tirzite, Dace</creatorcontrib><creatorcontrib>Cirule, Helena</creatorcontrib><creatorcontrib>Gulbe, Anita</creatorcontrib><creatorcontrib>Pugajeva, Iveta</creatorcontrib><creatorcontrib>Seglina, Dalija</creatorcontrib><creatorcontrib>Dambrova, Maija</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Makarova, Elina</au><au>Górnaś, Paweł</au><au>Konrade, Ilze</au><au>Tirzite, Dace</au><au>Cirule, Helena</au><au>Gulbe, Anita</au><au>Pugajeva, Iveta</au><au>Seglina, Dalija</au><au>Dambrova, Maija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>2015-02</date><risdate>2015</risdate><volume>95</volume><issue>3</issue><spage>560</spage><epage>568</epage><pages>560-568</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><coden>JSFAAE</coden><abstract>BACKGROUND
The health‐promoting properties of apples are directly related to the biologically active compounds that they contain, such as polyphenols. The objective of this study was to prepare a low‐sugar, fibre‐ and phlorizin‐enriched powder from unripe apples and to gain insight regarding its anti‐hyperglycaemic activity in healthy volunteers.
RESULTS
The unripe apples (Malus domestica Borkh.) were collected 30 days after the full bloom day; blanched and pressed to obtain apple pomace which was then processed with a food cutter, oven‐dried and milled to prepare apple powder. The concentrations of total sugars, water‐soluble pectin and phlorizin in the apple preparation were 153.44 ± 2.46, 27.73 ± 0.51 and 12.61 ± 0.15 g kg−1, respectively. Acute ingestion of the apple preparation improved glucose metabolism in the oral glucose tolerance test (OGTT) in six healthy volunteers by reducing the postprandial glucose response at 15 to 30 min by approximately two‐fold (P < 0.05) and by increasing urinary glucose excretion during the 2‐ to 4‐h interval of the OGTT by five‐fold (P < 0.05).
CONCLUSION
The results obtained indicate that the dried and powdered pomace of unripe apples can be used as a health‐promoting natural product for the reduction of postprandial glycaemia and to improve the health of patients with diabetes. © 2014 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>24917557</pmid><doi>10.1002/jsfa.6779</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of the science of food and agriculture, 2015-02, Vol.95 (3), p.560-568 |
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| subjects | Antioxidants Apples Blood Glucose - metabolism Blooming mills Chemical industries Cutters Diabetes Dietary Fiber - analysis Dietary Fiber - pharmacology Dietary Sucrose - analysis Dietary Sucrose - metabolism Female fibre Foods Fruit - chemistry Glucose glucose excretion Glucose Tolerance Test Healthy Volunteers Humans Hyperglycemia Hyperglycemia - blood Hyperglycemia - drug therapy Hypoglycemic Agents - analysis Hypoglycemic Agents - pharmacology Ingestion Malus - chemistry Metabolism Nutrition research Patients Pectins - analysis Pectins - pharmacology Phlorhizin - analysis Phlorhizin - pharmacology phlorizin Plant Extracts - chemistry Plant Extracts - pharmacology Polyphenols Polyphenols - pharmacology Postprandial Period Powders Reference Values unripe apples |
| title | Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study |
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