Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

Metformin has therapeutic potential against breast cancer, but the mechanisms of action in vivo remain uncertain. This study examined biomarker effects of metformin in primary breast cancer in a preoperative window of opportunity trial. Non-diabetic women with operable invasive breast cancer were ra...

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Veröffentlicht in:	Breast cancer research and treatment 2015-02, Vol.150 (1), p.149-155
Hauptverfasser:	Hadad, Sirwan M., Coates, Philip, Jordan, Lee B., Dowling, Ryan J. O., Chang, Martin C., Done, Susan J., Purdie, Colin A., Goodwin, Pamela J., Stambolic, Vuk, Moulder-Thompson, Stacy, Thompson, Alastair M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Biomarkers Biomarkers - metabolism Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer research Cancer therapies Caspase 3 - metabolism Clinical Trial Clinical trials Diabetes therapy Diabetics Drug therapy Female Health aspects Humans Immunohistochemistry Insulin Ki-67 Antigen - metabolism Medicine Medicine & Public Health Metformin - administration & dosage Metformin - therapeutic use Neoadjuvant Therapy Oncology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor, Insulin - metabolism Signal Transduction Treatment Outcome
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