Inhibition of interleukin-1β converting enzyme by the cowpox virus serpin CrmA

We reported previously that human interleukin-1 beta converting enzyme (ICE) is regulated by the CrmA serpin encoded by cowpox virus. We now report the mechanism and kinetics of this unusual inhibition of a cysteine proteinase by a member of the serpin superfamily previously thought to inhibit serin...

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Veröffentlicht in:	The Journal of biological chemistry 1994, Vol.269 (30), p.19331-19337
Hauptverfasser:	KOMIYAMA, T, RAY, C. A, PICKUP, D. J, HOWARD, A. D, THRONBERRY, N. A, PETERSON, E. P, SALVESEN, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences cowpox virus Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases
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