Contribution of the Transforming Growth Factor α B-loop β-Sheet to Binding and Activation of the Epidermal Growth Factor Receptor (∗)

We have exploited the differences in binding affinities of the chicken epidermal growth factor (EGF) receptor for EGF and transforming growth factor α (TGFα) to study the role of the B-loop β-sheet of these ligands in receptor recognition and activation. Although EGF and TGFα share similar secondary...

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