Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction
Purified rat peritoneal mast cells in vitro die over a period of 2-6 days in conventional serum-containing medium. As mast cells die, they become pyknotic and undergo DNA fragmentation suggestive of an apoptotic process. Treatment of in vitro mast cells with nerve growth factor (NGF) greatly retards...
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| Veröffentlicht in: | The Journal of biological chemistry 1994-01, Vol.269 (4), p.2695-2702 |
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| container_title | The Journal of biological chemistry |
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| creator | K Horigome E D Bullock E M Johnson, Jr |
| description | Purified rat peritoneal mast cells in vitro die over a period of 2-6 days in conventional serum-containing medium. As mast
cells die, they become pyknotic and undergo DNA fragmentation suggestive of an apoptotic process. Treatment of in vitro mast
cells with nerve growth factor (NGF) greatly retards and reduces the death of mast cells (EC50 approximately 1 nM), with no
effect on mast cell proliferation. Other neurotrophins have no such effect. NGF also induces the immediate early genes c-fos
and NGFI-A with a similar dose dependence. In contrast to the secretagogue activity of NGF, neither the survival-promoting
effect nor immediate early gene induction requires lysophosphatidylserine. The ability of NGF to promote mast cell survival
is cell density-dependent and appears to be primarily because of induction of the synthesis and/or secretion of an autocrine
survival factor by stimulated mast cells. These results suggest that the previously observed effects of NGF on mast cell numbers
in vivo may in part be because of enhanced survival and that NGF may be an important mediator of mast cell function in normal
and pathological states. |
| doi_str_mv | 10.1016/S0021-9258(17)41999-5 |
| format | Article |
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cells die, they become pyknotic and undergo DNA fragmentation suggestive of an apoptotic process. Treatment of in vitro mast
cells with nerve growth factor (NGF) greatly retards and reduces the death of mast cells (EC50 approximately 1 nM), with no
effect on mast cell proliferation. Other neurotrophins have no such effect. NGF also induces the immediate early genes c-fos
and NGFI-A with a similar dose dependence. In contrast to the secretagogue activity of NGF, neither the survival-promoting
effect nor immediate early gene induction requires lysophosphatidylserine. The ability of NGF to promote mast cell survival
is cell density-dependent and appears to be primarily because of induction of the synthesis and/or secretion of an autocrine
survival factor by stimulated mast cells. These results suggest that the previously observed effects of NGF on mast cell numbers
in vivo may in part be because of enhanced survival and that NGF may be an important mediator of mast cell function in normal
and pathological states.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(17)41999-5</identifier><identifier>PMID: 8300599</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Biochemistry and Molecular Biology</publisher><subject>Animals ; Biological and medical sciences ; Blotting, Northern ; Blotting, Southern ; Cell Death - drug effects ; Cell physiology ; Cell Survival - drug effects ; Cells, Cultured ; Culture Media, Conditioned ; Fundamental and applied biological sciences. Psychology ; Gene Expression - drug effects ; Genes, fos - drug effects ; Genes, Immediate-Early - drug effects ; Lysophospholipids - pharmacology ; Male ; Mast Cells - cytology ; Mast Cells - drug effects ; Mast Cells - metabolism ; Mice ; Molecular and cellular biology ; Nerve Growth Factors - pharmacology ; Peritoneal Cavity ; Rats ; Responses to growth factors, tumor promotors, other factors ; Serotonin - metabolism</subject><ispartof>The Journal of biological chemistry, 1994-01, Vol.269 (4), p.2695-2702</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-5835120d23b15d84aaabb621991f2060ca4b8572b209ecfb740048169abb3563</citedby><cites>FETCH-LOGICAL-c438t-5835120d23b15d84aaabb621991f2060ca4b8572b209ecfb740048169abb3563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4008101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8300599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>K Horigome</creatorcontrib><creatorcontrib>E D Bullock</creatorcontrib><creatorcontrib>E M Johnson, Jr</creatorcontrib><title>Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Purified rat peritoneal mast cells in vitro die over a period of 2-6 days in conventional serum-containing medium. As mast
cells die, they become pyknotic and undergo DNA fragmentation suggestive of an apoptotic process. Treatment of in vitro mast
cells with nerve growth factor (NGF) greatly retards and reduces the death of mast cells (EC50 approximately 1 nM), with no
effect on mast cell proliferation. Other neurotrophins have no such effect. NGF also induces the immediate early genes c-fos
and NGFI-A with a similar dose dependence. In contrast to the secretagogue activity of NGF, neither the survival-promoting
effect nor immediate early gene induction requires lysophosphatidylserine. The ability of NGF to promote mast cell survival
is cell density-dependent and appears to be primarily because of induction of the synthesis and/or secretion of an autocrine
survival factor by stimulated mast cells. These results suggest that the previously observed effects of NGF on mast cell numbers
in vivo may in part be because of enhanced survival and that NGF may be an important mediator of mast cell function in normal
and pathological states.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Blotting, Southern</subject><subject>Cell Death - drug effects</subject><subject>Cell physiology</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Culture Media, Conditioned</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Genes, fos - drug effects</subject><subject>Genes, Immediate-Early - drug effects</subject><subject>Lysophospholipids - pharmacology</subject><subject>Male</subject><subject>Mast Cells - cytology</subject><subject>Mast Cells - drug effects</subject><subject>Mast Cells - metabolism</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Peritoneal Cavity</subject><subject>Rats</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Serotonin - metabolism</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9v3CAQxVHVKt2m_QiRUFVV7cEpYGPDMYrSP1KkHpJDb2iMh10q22wBb5RvX5xdLQeQmN_MvPcIueLsmjPefntgTPBKC6m-8O5rw7XWlXxFNpypuqol__OabM7IW_Iupb-snEbzC3Khasak1hsS75xDmxMNjs4YD0i3MTzlHXVgc4g0zDRCpnuMPocZYaQTpEwtjmO6pg9LPPhD-dzHMIXsCw3zQP004eAhY4UQx2e6xRmpn4fFrsh78sbBmPDD6b0kj9_vHm9_Vve_f_y6vbmvbFOrXElVTAg2iLrnclANAPR9K4pP7gRrmYWmV7ITvWAareu7pphTvNUFq2VbX5LPx7FF278FUzaTT6tumDEsyfBWKs27FZRH0MaQUkRn9tFPEJ8NZ2aN2rxEbdYcDe_MS9RGlr6r04KlL37PXadsS_3TqQ7JwugizNanM1bkqjK9YB-P2M5vd08-oul9sDucjGi1adZb1v8BR9OS0g</recordid><startdate>19940128</startdate><enddate>19940128</enddate><creator>K Horigome</creator><creator>E D Bullock</creator><creator>E M Johnson, Jr</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19940128</creationdate><title>Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction</title><author>K Horigome ; E D Bullock ; E M Johnson, Jr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-5835120d23b15d84aaabb621991f2060ca4b8572b209ecfb740048169abb3563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Blotting, Southern</topic><topic>Cell Death - drug effects</topic><topic>Cell physiology</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Culture Media, Conditioned</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>Genes, fos - drug effects</topic><topic>Genes, Immediate-Early - drug effects</topic><topic>Lysophospholipids - pharmacology</topic><topic>Male</topic><topic>Mast Cells - cytology</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - metabolism</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>Peritoneal Cavity</topic><topic>Rats</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>K Horigome</creatorcontrib><creatorcontrib>E D Bullock</creatorcontrib><creatorcontrib>E M Johnson, Jr</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>K Horigome</au><au>E D Bullock</au><au>E M Johnson, Jr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1994-01-28</date><risdate>1994</risdate><volume>269</volume><issue>4</issue><spage>2695</spage><epage>2702</epage><pages>2695-2702</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>Purified rat peritoneal mast cells in vitro die over a period of 2-6 days in conventional serum-containing medium. As mast
cells die, they become pyknotic and undergo DNA fragmentation suggestive of an apoptotic process. Treatment of in vitro mast
cells with nerve growth factor (NGF) greatly retards and reduces the death of mast cells (EC50 approximately 1 nM), with no
effect on mast cell proliferation. Other neurotrophins have no such effect. NGF also induces the immediate early genes c-fos
and NGFI-A with a similar dose dependence. In contrast to the secretagogue activity of NGF, neither the survival-promoting
effect nor immediate early gene induction requires lysophosphatidylserine. The ability of NGF to promote mast cell survival
is cell density-dependent and appears to be primarily because of induction of the synthesis and/or secretion of an autocrine
survival factor by stimulated mast cells. These results suggest that the previously observed effects of NGF on mast cell numbers
in vivo may in part be because of enhanced survival and that NGF may be an important mediator of mast cell function in normal
and pathological states.</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>8300599</pmid><doi>10.1016/S0021-9258(17)41999-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of biological chemistry, 1994-01, Vol.269 (4), p.2695-2702 |
| issn | 0021-9258 1083-351X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blotting, Northern Blotting, Southern Cell Death - drug effects Cell physiology Cell Survival - drug effects Cells, Cultured Culture Media, Conditioned Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, fos - drug effects Genes, Immediate-Early - drug effects Lysophospholipids - pharmacology Male Mast Cells - cytology Mast Cells - drug effects Mast Cells - metabolism Mice Molecular and cellular biology Nerve Growth Factors - pharmacology Peritoneal Cavity Rats Responses to growth factors, tumor promotors, other factors Serotonin - metabolism |
| title | Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction |
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