Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions

We have isolated two independent mutations in the DNA-binding domain of the rat glucocorticoid receptor, P493R and S459A, that implicate DNA binding in the control of attached transcriptional activation domains, either that of the receptor itself or of VP16. The mutants are capable of activating tra...

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Veröffentlicht in:	Genes & development 1994-12, Vol.8 (23), p.2842-2856
Hauptverfasser:	Lefstin, J A, Thomas, J R, Yamamoto, K R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Amino Acid Sequence Animals Base Sequence Binding Sites Biological Evolution DNA - chemistry DNA - metabolism DNA Primers DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Mice Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Nucleic Acid Conformation Plasmids Point Mutation Protein Structure, Secondary Rats Receptors, Glucocorticoid - chemistry Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Sequence Homology, Amino Acid Teratoma Transcription, Genetic Transfection Tumor Cells, Cultured Zinc Fingers
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