Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress

Significance The biological factors that determine whether an individual develops mental illness, such as depression or posttraumatic stress disorder, or responds adequately to pharmacotherapy remain almost completely unknown. Using genetically modified mice, we demonstrate that low levels of brain...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-02, Vol.112 (8), p.2557-2562
Hauptverfasser:	Sachs, Benjamin D., Ni, Jason R., Caron, Marc G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use anxiety behavior disorders Biological Sciences Brain Brain - drug effects Brain - metabolism Disease Susceptibility Fluoxetine - pharmacology Fluoxetine - therapeutic use Gene Expression Regulation - drug effects Genotype & phenotype Mice patients psychological stress serotonin Serotonin - deficiency Serotonin - metabolism Stress Stress response Stress, Psychological - drug therapy Stress, Psychological - metabolism transgenic animals Tryptophan Hydroxylase - metabolism
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