An innovative solid oral nutritional supplement to fight weight loss and anorexia: open, randomised controlled trial of efficacy in institutionalised, malnourished older adults
To evaluate the impact of a solid nutritional supplement on the weight gain of institutionalised older adults>70 years with protein-energy malnutrition. The innovation of these high-protein and high-energy cookies was the texture adapted to edentulous patients (Protibis®, Solidages, France). An o...
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| Veröffentlicht in: | Age and ageing 2015-03, Vol.44 (2), p.245-251 |
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| creator | Pouyssegur, Valerie Brocker, Patrice Schneider, Stéphane M Philip, Jean Luc Barat, Philippe Reichert, Ewa Breugnon, Frederic Brunet, Didier Civalleri, Bruno Solere, Jean Paul Bensussan, Line Lupi-Pegurier, Laurence |
| description | To evaluate the impact of a solid nutritional supplement on the weight gain of institutionalised older adults>70 years with protein-energy malnutrition. The innovation of these high-protein and high-energy cookies was the texture adapted to edentulous patients (Protibis®, Solidages, France).
An open, multicentre, randomised controlled trial.
Seven nursing homes.
One hundred and seventy-five malnourished older adults, aged 86±8 years.
All participants received the standard institutional diet. In addition, Intervention group participants received eight cookies daily (11.5 g protein; 244 kcal) for 6 weeks (w0-w6).
Five visits (w-4, w0, w6, w10 and w18).
Percentage of weight gain from w0 to w6 (body mass in kg).
Appetite, rated using a numerical scale (0: no appetite to 10: extremely good appetite); current episodes of pressure ulcers and diarrhea.
Average weight increased in Intervention group (n=88) compared with Control group (n=87) without cookies supplementation (+1.6 versus -0.7%, P=0.038). Weight gain persisted 1 month (+3.0 versus -0.2%, P=0.025) and 3 months after the end of cookies consumption (+3.9 versus -0.9%, P=0.003), with diarrhea reduction (P=0.027). There was a synergistic effect with liquid/creamy dietary supplements. Subgroup analysis confirmed the positive impact of cookies supplementation alone on weight increase (P=0.024), appetite increase (P=0.009) and pressure ulcers reduction (P=0.031).
The trial suggested that, to fight against anorexia, the stimulation of touch (finger food; chewing, even on edentulous gums) and hearing (intra-oral sounds) could be valuable alternatives to sight, smell and taste alterations. |
| doi_str_mv | 10.1093/ageing/afu150 |
| format | Article |
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An open, multicentre, randomised controlled trial.
Seven nursing homes.
One hundred and seventy-five malnourished older adults, aged 86±8 years.
All participants received the standard institutional diet. In addition, Intervention group participants received eight cookies daily (11.5 g protein; 244 kcal) for 6 weeks (w0-w6).
Five visits (w-4, w0, w6, w10 and w18).
Percentage of weight gain from w0 to w6 (body mass in kg).
Appetite, rated using a numerical scale (0: no appetite to 10: extremely good appetite); current episodes of pressure ulcers and diarrhea.
Average weight increased in Intervention group (n=88) compared with Control group (n=87) without cookies supplementation (+1.6 versus -0.7%, P=0.038). Weight gain persisted 1 month (+3.0 versus -0.2%, P=0.025) and 3 months after the end of cookies consumption (+3.9 versus -0.9%, P=0.003), with diarrhea reduction (P=0.027). There was a synergistic effect with liquid/creamy dietary supplements. Subgroup analysis confirmed the positive impact of cookies supplementation alone on weight increase (P=0.024), appetite increase (P=0.009) and pressure ulcers reduction (P=0.031).
The trial suggested that, to fight against anorexia, the stimulation of touch (finger food; chewing, even on edentulous gums) and hearing (intra-oral sounds) could be valuable alternatives to sight, smell and taste alterations.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afu150</identifier><identifier>PMID: 25324332</identifier><identifier>CODEN: AANGAH</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Aging ; Anorexia ; Anorexia - diagnosis ; Anorexia - physiopathology ; Anorexia - psychology ; Anorexia - therapy ; Anorexia nervosa ; Appetite ; Care and treatment ; Clinical trials ; Diet ; Dietary Proteins - administration & dosage ; Dietary supplements ; Elderly ; Emotions ; Energy Intake ; Enteral Nutrition - methods ; Female ; Food, Formulated ; France ; Geriatric Assessment ; Health aspects ; Homes for the Aged ; Humans ; Male ; Malnutrition ; Nursing Homes ; Nutrition Assessment ; Nutritional Status ; Older people ; Protein-energy malnutrition ; Protein-Energy Malnutrition - diagnosis ; Protein-Energy Malnutrition - physiopathology ; Protein-Energy Malnutrition - psychology ; Protein-Energy Malnutrition - therapy ; Time Factors ; Treatment Outcome ; Weight control ; Weight Gain ; Weight Loss</subject><ispartof>Age and ageing, 2015-03, Vol.44 (2), p.245-251</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><rights>Copyright Oxford Publishing Limited(England) Mar 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-61d32178f53f8c654c078228819c267791c705c7ee928d9b5d10c5207ce267c43</citedby><cites>FETCH-LOGICAL-c359t-61d32178f53f8c654c078228819c267791c705c7ee928d9b5d10c5207ce267c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934,31008</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25324332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pouyssegur, Valerie</creatorcontrib><creatorcontrib>Brocker, Patrice</creatorcontrib><creatorcontrib>Schneider, Stéphane M</creatorcontrib><creatorcontrib>Philip, Jean Luc</creatorcontrib><creatorcontrib>Barat, Philippe</creatorcontrib><creatorcontrib>Reichert, Ewa</creatorcontrib><creatorcontrib>Breugnon, Frederic</creatorcontrib><creatorcontrib>Brunet, Didier</creatorcontrib><creatorcontrib>Civalleri, Bruno</creatorcontrib><creatorcontrib>Solere, Jean Paul</creatorcontrib><creatorcontrib>Bensussan, Line</creatorcontrib><creatorcontrib>Lupi-Pegurier, Laurence</creatorcontrib><title>An innovative solid oral nutritional supplement to fight weight loss and anorexia: open, randomised controlled trial of efficacy in institutionalised, malnourished older adults</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><description>To evaluate the impact of a solid nutritional supplement on the weight gain of institutionalised older adults>70 years with protein-energy malnutrition. The innovation of these high-protein and high-energy cookies was the texture adapted to edentulous patients (Protibis®, Solidages, France).
An open, multicentre, randomised controlled trial.
Seven nursing homes.
One hundred and seventy-five malnourished older adults, aged 86±8 years.
All participants received the standard institutional diet. In addition, Intervention group participants received eight cookies daily (11.5 g protein; 244 kcal) for 6 weeks (w0-w6).
Five visits (w-4, w0, w6, w10 and w18).
Percentage of weight gain from w0 to w6 (body mass in kg).
Appetite, rated using a numerical scale (0: no appetite to 10: extremely good appetite); current episodes of pressure ulcers and diarrhea.
Average weight increased in Intervention group (n=88) compared with Control group (n=87) without cookies supplementation (+1.6 versus -0.7%, P=0.038). Weight gain persisted 1 month (+3.0 versus -0.2%, P=0.025) and 3 months after the end of cookies consumption (+3.9 versus -0.9%, P=0.003), with diarrhea reduction (P=0.027). There was a synergistic effect with liquid/creamy dietary supplements. Subgroup analysis confirmed the positive impact of cookies supplementation alone on weight increase (P=0.024), appetite increase (P=0.009) and pressure ulcers reduction (P=0.031).
The trial suggested that, to fight against anorexia, the stimulation of touch (finger food; chewing, even on edentulous gums) and hearing (intra-oral sounds) could be valuable alternatives to sight, smell and taste alterations.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Anorexia</subject><subject>Anorexia - diagnosis</subject><subject>Anorexia - physiopathology</subject><subject>Anorexia - psychology</subject><subject>Anorexia - therapy</subject><subject>Anorexia nervosa</subject><subject>Appetite</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Diet</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary supplements</subject><subject>Elderly</subject><subject>Emotions</subject><subject>Energy Intake</subject><subject>Enteral Nutrition - methods</subject><subject>Female</subject><subject>Food, Formulated</subject><subject>France</subject><subject>Geriatric Assessment</subject><subject>Health aspects</subject><subject>Homes for the Aged</subject><subject>Humans</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Nursing Homes</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Older people</subject><subject>Protein-energy malnutrition</subject><subject>Protein-Energy Malnutrition - diagnosis</subject><subject>Protein-Energy Malnutrition - physiopathology</subject><subject>Protein-Energy Malnutrition - psychology</subject><subject>Protein-Energy Malnutrition - therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Weight control</subject><subject>Weight Gain</subject><subject>Weight Loss</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNpdkUtvFSEUx4nR2Gt16daQuHHRsTyGgXF3c-MradKNrgllzkxpGLgC08e38iPKOFUTEwgH-J3nH6HXlLynpOfnZgIXpnMzLlSQJ2hH2041TPH2KdoRQlhDJOtP0Iucb-qVCsqeoxMmOGs5Zzv0cx-wCyHemuJuAefo3YBjMh6HpSRXXAzVzsvx6GGGUHCJeHTTdcF38PvwMWdswlB3THDvzAccjxDOcKqPcXYZBmxjKCl6X80as8aLI4ZxdNbYh5q9rlxcWbZkq8cZno0PcUkuX1en6AdI2AyLL_klejYan-HV43mKvn_6-O3wpbm4_Pz1sL9oLBd9aTo6cEalGgUfle1Ea4lUjClFe8s6KXtqJRFWAvRMDf2VGCixghFpoX7blp-id1vcY4o_FshF114seG8CxCVr2glVI4hWVPTtf-hNLb22slIdlVS1klWq2ajJeNAurEOB-2LXuUyga_GHS71vV1wwqf7xNtURJxj1MbnZpAdNiV6l15v0epO-8m8eq1iuZhj-0n-05r8AFOeuBQ</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Pouyssegur, Valerie</creator><creator>Brocker, Patrice</creator><creator>Schneider, Stéphane M</creator><creator>Philip, Jean Luc</creator><creator>Barat, Philippe</creator><creator>Reichert, Ewa</creator><creator>Breugnon, Frederic</creator><creator>Brunet, Didier</creator><creator>Civalleri, Bruno</creator><creator>Solere, Jean Paul</creator><creator>Bensussan, Line</creator><creator>Lupi-Pegurier, Laurence</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>An innovative solid oral nutritional supplement to fight weight loss and anorexia: open, randomised controlled trial of efficacy in institutionalised, malnourished older adults</title><author>Pouyssegur, Valerie ; Brocker, Patrice ; Schneider, Stéphane M ; Philip, Jean Luc ; Barat, Philippe ; Reichert, Ewa ; Breugnon, Frederic ; Brunet, Didier ; Civalleri, Bruno ; Solere, Jean Paul ; Bensussan, Line ; Lupi-Pegurier, Laurence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-61d32178f53f8c654c078228819c267791c705c7ee928d9b5d10c5207ce267c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Anorexia</topic><topic>Anorexia - diagnosis</topic><topic>Anorexia - physiopathology</topic><topic>Anorexia - psychology</topic><topic>Anorexia - therapy</topic><topic>Anorexia nervosa</topic><topic>Appetite</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Diet</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary supplements</topic><topic>Elderly</topic><topic>Emotions</topic><topic>Energy Intake</topic><topic>Enteral Nutrition - methods</topic><topic>Female</topic><topic>Food, Formulated</topic><topic>France</topic><topic>Geriatric Assessment</topic><topic>Health aspects</topic><topic>Homes for the Aged</topic><topic>Humans</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Nursing Homes</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Older people</topic><topic>Protein-energy malnutrition</topic><topic>Protein-Energy Malnutrition - diagnosis</topic><topic>Protein-Energy Malnutrition - physiopathology</topic><topic>Protein-Energy Malnutrition - psychology</topic><topic>Protein-Energy Malnutrition - therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Weight control</topic><topic>Weight Gain</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pouyssegur, Valerie</creatorcontrib><creatorcontrib>Brocker, Patrice</creatorcontrib><creatorcontrib>Schneider, Stéphane M</creatorcontrib><creatorcontrib>Philip, Jean Luc</creatorcontrib><creatorcontrib>Barat, Philippe</creatorcontrib><creatorcontrib>Reichert, Ewa</creatorcontrib><creatorcontrib>Breugnon, Frederic</creatorcontrib><creatorcontrib>Brunet, Didier</creatorcontrib><creatorcontrib>Civalleri, Bruno</creatorcontrib><creatorcontrib>Solere, Jean Paul</creatorcontrib><creatorcontrib>Bensussan, Line</creatorcontrib><creatorcontrib>Lupi-Pegurier, Laurence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pouyssegur, Valerie</au><au>Brocker, Patrice</au><au>Schneider, Stéphane M</au><au>Philip, Jean Luc</au><au>Barat, Philippe</au><au>Reichert, Ewa</au><au>Breugnon, Frederic</au><au>Brunet, Didier</au><au>Civalleri, Bruno</au><au>Solere, Jean Paul</au><au>Bensussan, Line</au><au>Lupi-Pegurier, Laurence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An innovative solid oral nutritional supplement to fight weight loss and anorexia: open, randomised controlled trial of efficacy in institutionalised, malnourished older adults</atitle><jtitle>Age and ageing</jtitle><addtitle>Age Ageing</addtitle><date>2015-03</date><risdate>2015</risdate><volume>44</volume><issue>2</issue><spage>245</spage><epage>251</epage><pages>245-251</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><coden>AANGAH</coden><abstract>To evaluate the impact of a solid nutritional supplement on the weight gain of institutionalised older adults>70 years with protein-energy malnutrition. The innovation of these high-protein and high-energy cookies was the texture adapted to edentulous patients (Protibis®, Solidages, France).
An open, multicentre, randomised controlled trial.
Seven nursing homes.
One hundred and seventy-five malnourished older adults, aged 86±8 years.
All participants received the standard institutional diet. In addition, Intervention group participants received eight cookies daily (11.5 g protein; 244 kcal) for 6 weeks (w0-w6).
Five visits (w-4, w0, w6, w10 and w18).
Percentage of weight gain from w0 to w6 (body mass in kg).
Appetite, rated using a numerical scale (0: no appetite to 10: extremely good appetite); current episodes of pressure ulcers and diarrhea.
Average weight increased in Intervention group (n=88) compared with Control group (n=87) without cookies supplementation (+1.6 versus -0.7%, P=0.038). Weight gain persisted 1 month (+3.0 versus -0.2%, P=0.025) and 3 months after the end of cookies consumption (+3.9 versus -0.9%, P=0.003), with diarrhea reduction (P=0.027). There was a synergistic effect with liquid/creamy dietary supplements. Subgroup analysis confirmed the positive impact of cookies supplementation alone on weight increase (P=0.024), appetite increase (P=0.009) and pressure ulcers reduction (P=0.031).
The trial suggested that, to fight against anorexia, the stimulation of touch (finger food; chewing, even on edentulous gums) and hearing (intra-oral sounds) could be valuable alternatives to sight, smell and taste alterations.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25324332</pmid><doi>10.1093/ageing/afu150</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Age and ageing, 2015-03, Vol.44 (2), p.245-251 |
| issn | 0002-0729 1468-2834 |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Age Factors Aged Aged, 80 and over Aging Anorexia Anorexia - diagnosis Anorexia - physiopathology Anorexia - psychology Anorexia - therapy Anorexia nervosa Appetite Care and treatment Clinical trials Diet Dietary Proteins - administration & dosage Dietary supplements Elderly Emotions Energy Intake Enteral Nutrition - methods Female Food, Formulated France Geriatric Assessment Health aspects Homes for the Aged Humans Male Malnutrition Nursing Homes Nutrition Assessment Nutritional Status Older people Protein-energy malnutrition Protein-Energy Malnutrition - diagnosis Protein-Energy Malnutrition - physiopathology Protein-Energy Malnutrition - psychology Protein-Energy Malnutrition - therapy Time Factors Treatment Outcome Weight control Weight Gain Weight Loss |
| title | An innovative solid oral nutritional supplement to fight weight loss and anorexia: open, randomised controlled trial of efficacy in institutionalised, malnourished older adults |
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