Is a CIS phenotype apparent in children with Disorders of Sex Development? Milder testicular dysgenesis is associated with a higher risk of malignancy

Summary All malignant testicular germ cell tumors (TGCT) of adult men are preceded by an in situ stage (CIS) of protracted evolution. The adult CIS is well characterized, but there is debate on the phenotype of infantile CIS, its distinction from delayed maturation of germ cells and prognostic poten...

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Veröffentlicht in:	Andrology (Oxford) 2015-01, Vol.3 (1), p.59-69
Hauptverfasser:	Chemes, H. E., Venara, M., Rey, G., Arcari, A. J., Musse, M. P., Papazian, R., Forclaz, V., Gottlieb, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Argentina - epidemiology Biomarkers, Tumor - genetics Carcinoma in Situ - chemistry Carcinoma in Situ - epidemiology Carcinoma in Situ - genetics Carcinoma in Situ - pathology Child Child, Preschool CIS markers Disorders of Sex Development DSD Female Genetic Predisposition to Disease Genetic Testing Gonadal Dysgenesis - epidemiology Gonadal Dysgenesis - genetics Humans Incidence Infant Infant, Newborn Male OCT 3/4 Octamer Transcription Factor-3 - analysis Phenotype Ploidies ploidy Predictive Value of Tests prognostic factors Retrospective Studies Risk Assessment Risk Factors Seminoma - chemistry Seminoma - epidemiology Seminoma - genetics Seminoma - pathology Sexual Development - genetics testicular carcinoma in situ (CIS) testicular dysgenesis testicular germ cell tumor (TGCT) Testicular Neoplasms - chemistry Testicular Neoplasms - epidemiology Testicular Neoplasms - genetics Testicular Neoplasms - pathology Young Adult
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