Rodent versus human insulitis: why the huge disconnect?
The purpose of this article is to summarize recent developments in the histopathology of recent-onset type 1 diabetes. Insulitis is considered to be the defining lesion in young type 1 diabetic patients, and insight into its pathogenic mechanism is crucial for the development of effective new therap...
Gespeichert in:
| Veröffentlicht in: | Current opinion in endocrinology, diabetes, and obesity diabetes, and obesity, 2015-04, Vol.22 (2), p.86-90 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | 2 |
| container_start_page | 86 |
| container_title | Current opinion in endocrinology, diabetes, and obesity |
| container_volume | 22 |
| creator | in’t Veld, Peter |
| description | The purpose of this article is to summarize recent developments in the histopathology of recent-onset type 1 diabetes.
Insulitis is considered to be the defining lesion in young type 1 diabetic patients, and insight into its pathogenic mechanism is crucial for the development of effective new therapies. The present overview highlights some recent developments including an international consensus guideline for the diagnosis of insulitis in type 1 diabetic patients, immunophenotyping of the insulitic lesions, evidence for a heterogeneity of the disease process and a discussion on the differences and similarities between insulitis in patients and in rodent models of the disease.
We have reviewed recent data, published over the last year, on the nature and mechanism of insulitis in both patients and the nonobese diabetic mouse model. |
| doi_str_mv | 10.1097/MED.0000000000000135 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1658704392</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1658704392</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3014-9ea9c6e45618bd2a9e6b46544f527e46733542832e10b8e65c7eab039b50bd5b3</originalsourceid><addsrcrecordid>eNpdkFtLw0AQhRdRbK3-A5E8-pI6e8_6IlLrBSqCKPi2bJKpieZSs4ml_96U1gvOywzMOWeGj5BjCmMKRp_dT6_G8LcolztkSLVkITM62v2Z1cuAHHj_BiC1lnKfDJhUhhkGQ6If6xSrNvjExnc-yLrSVUFe-a7I29yfB8tsFbQZ9otXDNLcJ3VVYdJeHJK9uSs8Hm37iDxfT58mt-Hs4eZucjkLEw5UhAadSRQKqWgUp8wZVLFQUoi5ZBqF0pxLwSLOkEIcoZKJRhcDN7GEOJUxH5HTTe6iqT869K0t-yewKFyFdectVTLSILhhvVRspElTe9_g3C6avHTNylKwa2S2R2b_I-ttJ9sLXVxi-mP6ZvSbu6yLtsf0XnRLbGyGrmgzC5QpBcyEDKgE0YeG62TBvwBO0nTD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1658704392</pqid></control><display><type>article</type><title>Rodent versus human insulitis: why the huge disconnect?</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>in’t Veld, Peter</creator><creatorcontrib>in’t Veld, Peter</creatorcontrib><description>The purpose of this article is to summarize recent developments in the histopathology of recent-onset type 1 diabetes.
Insulitis is considered to be the defining lesion in young type 1 diabetic patients, and insight into its pathogenic mechanism is crucial for the development of effective new therapies. The present overview highlights some recent developments including an international consensus guideline for the diagnosis of insulitis in type 1 diabetic patients, immunophenotyping of the insulitic lesions, evidence for a heterogeneity of the disease process and a discussion on the differences and similarities between insulitis in patients and in rodent models of the disease.
We have reviewed recent data, published over the last year, on the nature and mechanism of insulitis in both patients and the nonobese diabetic mouse model.</description><identifier>ISSN: 1752-296X</identifier><identifier>EISSN: 1752-2978</identifier><identifier>DOI: 10.1097/MED.0000000000000135</identifier><identifier>PMID: 25692920</identifier><language>eng</language><publisher>England: Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Animals ; Autoimmunity ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - physiopathology ; Disease Models, Animal ; Humans ; Mice, Inbred NOD ; Pancreas - immunology ; Pancreas - metabolism ; Pancreas - physiopathology ; Prognosis ; Species Specificity ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Translational Medical Research</subject><ispartof>Current opinion in endocrinology, diabetes, and obesity, 2015-04, Vol.22 (2), p.86-90</ispartof><rights>Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3014-9ea9c6e45618bd2a9e6b46544f527e46733542832e10b8e65c7eab039b50bd5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25692920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>in’t Veld, Peter</creatorcontrib><title>Rodent versus human insulitis: why the huge disconnect?</title><title>Current opinion in endocrinology, diabetes, and obesity</title><addtitle>Curr Opin Endocrinol Diabetes Obes</addtitle><description>The purpose of this article is to summarize recent developments in the histopathology of recent-onset type 1 diabetes.
Insulitis is considered to be the defining lesion in young type 1 diabetic patients, and insight into its pathogenic mechanism is crucial for the development of effective new therapies. The present overview highlights some recent developments including an international consensus guideline for the diagnosis of insulitis in type 1 diabetic patients, immunophenotyping of the insulitic lesions, evidence for a heterogeneity of the disease process and a discussion on the differences and similarities between insulitis in patients and in rodent models of the disease.
We have reviewed recent data, published over the last year, on the nature and mechanism of insulitis in both patients and the nonobese diabetic mouse model.</description><subject>Animals</subject><subject>Autoimmunity</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Mice, Inbred NOD</subject><subject>Pancreas - immunology</subject><subject>Pancreas - metabolism</subject><subject>Pancreas - physiopathology</subject><subject>Prognosis</subject><subject>Species Specificity</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Translational Medical Research</subject><issn>1752-296X</issn><issn>1752-2978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtLw0AQhRdRbK3-A5E8-pI6e8_6IlLrBSqCKPi2bJKpieZSs4ml_96U1gvOywzMOWeGj5BjCmMKRp_dT6_G8LcolztkSLVkITM62v2Z1cuAHHj_BiC1lnKfDJhUhhkGQ6If6xSrNvjExnc-yLrSVUFe-a7I29yfB8tsFbQZ9otXDNLcJ3VVYdJeHJK9uSs8Hm37iDxfT58mt-Hs4eZucjkLEw5UhAadSRQKqWgUp8wZVLFQUoi5ZBqF0pxLwSLOkEIcoZKJRhcDN7GEOJUxH5HTTe6iqT869K0t-yewKFyFdectVTLSILhhvVRspElTe9_g3C6avHTNylKwa2S2R2b_I-ttJ9sLXVxi-mP6ZvSbu6yLtsf0XnRLbGyGrmgzC5QpBcyEDKgE0YeG62TBvwBO0nTD</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>in’t Veld, Peter</creator><general>Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Rodent versus human insulitis: why the huge disconnect?</title><author>in’t Veld, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3014-9ea9c6e45618bd2a9e6b46544f527e46733542832e10b8e65c7eab039b50bd5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Autoimmunity</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Mice, Inbred NOD</topic><topic>Pancreas - immunology</topic><topic>Pancreas - metabolism</topic><topic>Pancreas - physiopathology</topic><topic>Prognosis</topic><topic>Species Specificity</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Translational Medical Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>in’t Veld, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in endocrinology, diabetes, and obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>in’t Veld, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rodent versus human insulitis: why the huge disconnect?</atitle><jtitle>Current opinion in endocrinology, diabetes, and obesity</jtitle><addtitle>Curr Opin Endocrinol Diabetes Obes</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>22</volume><issue>2</issue><spage>86</spage><epage>90</epage><pages>86-90</pages><issn>1752-296X</issn><eissn>1752-2978</eissn><abstract>The purpose of this article is to summarize recent developments in the histopathology of recent-onset type 1 diabetes.
Insulitis is considered to be the defining lesion in young type 1 diabetic patients, and insight into its pathogenic mechanism is crucial for the development of effective new therapies. The present overview highlights some recent developments including an international consensus guideline for the diagnosis of insulitis in type 1 diabetic patients, immunophenotyping of the insulitic lesions, evidence for a heterogeneity of the disease process and a discussion on the differences and similarities between insulitis in patients and in rodent models of the disease.
We have reviewed recent data, published over the last year, on the nature and mechanism of insulitis in both patients and the nonobese diabetic mouse model.</abstract><cop>England</cop><pub>Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>25692920</pmid><doi>10.1097/MED.0000000000000135</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1752-296X |
| ispartof | Current opinion in endocrinology, diabetes, and obesity, 2015-04, Vol.22 (2), p.86-90 |
| issn | 1752-296X 1752-2978 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1658704392 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Autoimmunity Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - physiopathology Disease Models, Animal Humans Mice, Inbred NOD Pancreas - immunology Pancreas - metabolism Pancreas - physiopathology Prognosis Species Specificity T-Lymphocytes - immunology T-Lymphocytes - metabolism Translational Medical Research |
| title | Rodent versus human insulitis: why the huge disconnect? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A22%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rodent%20versus%20human%20insulitis:%20why%20the%20huge%20disconnect?&rft.jtitle=Current%20opinion%20in%20endocrinology,%20diabetes,%20and%20obesity&rft.au=in%E2%80%99t%20Veld,%20Peter&rft.date=2015-04-01&rft.volume=22&rft.issue=2&rft.spage=86&rft.epage=90&rft.pages=86-90&rft.issn=1752-296X&rft.eissn=1752-2978&rft_id=info:doi/10.1097/MED.0000000000000135&rft_dat=%3Cproquest_cross%3E1658704392%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1658704392&rft_id=info:pmid/25692920&rfr_iscdi=true |