Basal forebrain cholinergic neurons are selectively vulnerable to AMPA/kainate receptor-mediated neurotoxicity

We exposed murine basal forebrain neuronal cultures for 24 h to denned concentrations of N-methyl- d-aspartate, kainate or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, and assessed the resultant degeneration of the cholinergic neuronal subpopulation, as identified by choline acetyltransferase i...

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Veröffentlicht in:	Neuroscience 1994-06, Vol.60 (3), p.659-664
Hauptverfasser:	Weiss, J.H., Yin, H.-Z., Choi, D.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine acetylcholinesterase Acetylcholinesterase - analysis AChE alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - toxicity Alzheimer Disease - metabolism AMPA Animals Biological and medical sciences Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors ChAT choline acetyltransferase Choline O-Acetyltransferase - analysis EDTA ethylenediaminetetra-acetate Fundamental and applied biological sciences. Psychology Kainic Acid - toxicity lactate dehydrogenase LDH Mice N-methyl- d-aspartate N-Methylaspartate - toxicity Nerve Tissue Proteins - analysis Neurons - drug effects NMDA PBS phosphatebuffered saline Prosencephalon - cytology Prosencephalon - drug effects Prosencephalon - embryology Receptors, AMPA - drug effects Receptors, AMPA - physiology Receptors, Kainic Acid - drug effects Receptors, Kainic Acid - physiology Vertebrates: nervous system and sense organs αamino-3-hydroxγ-5-methyl-4-isoxazolepropionic acid
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