Effect of Low Versus High Dialysate Sodium Concentration on Blood Pressure and Endothelial-Derived Vasoregulators During Hemodialysis: A Randomized Crossover Study

Background Intradialytic hypertension affects ∼15% of hemodialysis patients and is associated with increased morbidity and mortality. While intradialytic hypertension is associated with increases in endothelin 1 relative to nitric oxide (NO), the cause of these imbalances is unknown. In vitro eviden...

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Veröffentlicht in:	American journal of kidney diseases 2015-03, Vol.65 (3), p.464-473
Hauptverfasser:	Inrig, Jula K., MD, MHS, Molina, Christopher, BS, D’Silva, Kristin, BS, Kim, Catherine, MD, Van Buren, Peter, MD, Allen, Jason D., PhD, Toto, Robert, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged blood pressure (BP) Blood Pressure - drug effects Blood Pressure - physiology Cross-Over Studies dialysate sodium concentration Dialysis Solutions - administration & dosage Dialysis Solutions - adverse effects end-stage renal disease (ESRD) endothelin 1 Endothelin-1 - blood endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female hemodialysis Humans Hypertension - blood Hypertension - chemically induced Hypertension - prevention & control Intradialytic hypertension Male Mechanisms and Treatment of Intradialytic Hypertension–Sodium (MATCH-NA) Study Middle Aged Nephrology nitric oxide nitrite Nitrites - blood Prospective Studies Renal Dialysis - adverse effects serum sodium concentration Single-Blind Method Sodium - administration & dosage Sodium - adverse effects sodium gradient Treatment Outcome vasoregulation
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