pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes
A range of bidentate N,O-donor ligands of the imidazolyl-carboxylate moiety, which partially mimic naturally occurring bioligands, were prepared and reacted with the oxidovanadium(IV) ion to form the corresponding bis-coordinated oxidovanadium(IV) complexes. The aqueous pH-metric chemical speciation...
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Veröffentlicht in: | Journal of inorganic biochemistry 2015-04, Vol.145, p.11-18 |
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container_title | Journal of inorganic biochemistry |
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creator | Gundhla, Isaac Z. Walmsley, Ryan S. Ugirinema, Vital Mnonopi, Nandipha O. Hosten, Eric Betz, Richard Frost, Carminita L. Tshentu, Zenixole R. |
description | A range of bidentate N,O-donor ligands of the imidazolyl-carboxylate moiety, which partially mimic naturally occurring bioligands, were prepared and reacted with the oxidovanadium(IV) ion to form the corresponding bis-coordinated oxidovanadium(IV) complexes. The aqueous pH-metric chemical speciation was investigated using glass electrode potentiometry, which allowed for the determination of protonation and stability constants of the ligands and complexes, respectively. The species distribution diagrams generated from this information gave evidence that the bis[(imidazolyl)carboxylato]oxovanadium(IV) complexes possess a broad pH-metric stability. The complexes improved glucose uptake in cell cultures using 3T3-L1 adipocytes, C2C12 muscle cells and Chang liver cells. The PTP inhibition studies indicated that the mechanism underlying insulin-stimulated glucose uptake was possibly via the protein tyrosine phosphorylation through the inhibition of the protein tyrosine phosphatase 1B (PTP 1B). The vanadium compounds also demonstrated the inhibition of D-dimer formation, suggesting that these compounds could potentially relieve a hypercoagulative state in diabetic patients.
The bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes show potential as anti-diabetic agents. [Display omitted]
•Oxidovanadium(IV) was stabilized by the imidazolyl-carboxylato moiety under physiological pH.•The isolated complexes were shown to activate glucose uptake in cell cultures.•The complexes showed inhibitory effect towards protein tyrosine phosphatase (PTP 1B).•The complexes also showed the inhibition of D-dimer formation. |
doi_str_mv | 10.1016/j.jinorgbio.2014.12.019 |
format | Article |
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The bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes show potential as anti-diabetic agents. [Display omitted]
•Oxidovanadium(IV) was stabilized by the imidazolyl-carboxylato moiety under physiological pH.•The isolated complexes were shown to activate glucose uptake in cell cultures.•The complexes showed inhibitory effect towards protein tyrosine phosphatase (PTP 1B).•The complexes also showed the inhibition of D-dimer formation.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2014.12.019</identifier><identifier>PMID: 25594947</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3T3-L1 Cells ; Adipocytes - drug effects ; Adipocytes - metabolism ; Animals ; Anti-coagulative effects ; Anti-diabetic effects ; Anticoagulants - pharmacology ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Crystallography, X-Ray ; Enzyme Inhibitors - pharmacology ; Glucose - metabolism ; Hydrogen-Ion Concentration ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; In Vitro Techniques ; Mice ; Models, Chemical ; Oxidovanadium(IV) complexes ; Speciation</subject><ispartof>Journal of inorganic biochemistry, 2015-04, Vol.145, p.11-18</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-f78367cf999e84bbb423b8f6f12edc8a8d6f5edee20f13f703b4a13f7e8898773</citedby><cites>FETCH-LOGICAL-c371t-f78367cf999e84bbb423b8f6f12edc8a8d6f5edee20f13f703b4a13f7e8898773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinorgbio.2014.12.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25594947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gundhla, Isaac Z.</creatorcontrib><creatorcontrib>Walmsley, Ryan S.</creatorcontrib><creatorcontrib>Ugirinema, Vital</creatorcontrib><creatorcontrib>Mnonopi, Nandipha O.</creatorcontrib><creatorcontrib>Hosten, Eric</creatorcontrib><creatorcontrib>Betz, Richard</creatorcontrib><creatorcontrib>Frost, Carminita L.</creatorcontrib><creatorcontrib>Tshentu, Zenixole R.</creatorcontrib><title>pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>A range of bidentate N,O-donor ligands of the imidazolyl-carboxylate moiety, which partially mimic naturally occurring bioligands, were prepared and reacted with the oxidovanadium(IV) ion to form the corresponding bis-coordinated oxidovanadium(IV) complexes. The aqueous pH-metric chemical speciation was investigated using glass electrode potentiometry, which allowed for the determination of protonation and stability constants of the ligands and complexes, respectively. The species distribution diagrams generated from this information gave evidence that the bis[(imidazolyl)carboxylato]oxovanadium(IV) complexes possess a broad pH-metric stability. The complexes improved glucose uptake in cell cultures using 3T3-L1 adipocytes, C2C12 muscle cells and Chang liver cells. The PTP inhibition studies indicated that the mechanism underlying insulin-stimulated glucose uptake was possibly via the protein tyrosine phosphorylation through the inhibition of the protein tyrosine phosphatase 1B (PTP 1B). The vanadium compounds also demonstrated the inhibition of D-dimer formation, suggesting that these compounds could potentially relieve a hypercoagulative state in diabetic patients.
The bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes show potential as anti-diabetic agents. [Display omitted]
•Oxidovanadium(IV) was stabilized by the imidazolyl-carboxylato moiety under physiological pH.•The isolated complexes were shown to activate glucose uptake in cell cultures.•The complexes showed inhibitory effect towards protein tyrosine phosphatase (PTP 1B).•The complexes also showed the inhibition of D-dimer formation.</description><subject>3T3-L1 Cells</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Animals</subject><subject>Anti-coagulative effects</subject><subject>Anti-diabetic effects</subject><subject>Anticoagulants - pharmacology</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination Complexes - pharmacology</subject><subject>Crystallography, X-Ray</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Glucose - metabolism</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Mice</subject><subject>Models, Chemical</subject><subject>Oxidovanadium(IV) complexes</subject><subject>Speciation</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EotvCK0CO20OCnTixc6yqQitV4gJcELL8Z1xmlcSL7ax2eQieuVm29MppRqPffJ9mPkLeM1oxyroPm2qDU4gPBkNVU8YrVleU9S_IiknRlE3D-UuyWsi6pKzhZ-Q8pQ2ltG25eE3O6rbtec_FivzZ3pYj5Ii2sD9hRKuHIm3Bos4YpmIMDgacHgo9uSLl2SGkIvgCp2KHOYZlntGhNpAXBfAebP4LGEzf1zii07_DcBgurY4m7A-DzuFH2KMLOz1ph_O4vvt2WdgwbgfYQ3pDXnk9JHj7VC_I1483X65vy_vPn-6ur-5L2wiWSy9k0wnr-74HyY0xvG6M9J1nNTgrtXSdb8EB1NSzxgvaGK6PDUjZSyGaC7I-6W5j-DVDymrEZGEY9ARhTop1reQ1590RFSfUxpBSBK-2EUcdD4pRdQxDbdRzGOoYhmK1WsJYNt89mcxmBPe89-_7C3B1AmA5dYcQVbIIkwWHcXmkcgH_a_IIobGjuA</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Gundhla, Isaac Z.</creator><creator>Walmsley, Ryan S.</creator><creator>Ugirinema, Vital</creator><creator>Mnonopi, Nandipha O.</creator><creator>Hosten, Eric</creator><creator>Betz, Richard</creator><creator>Frost, Carminita L.</creator><creator>Tshentu, Zenixole R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes</title><author>Gundhla, Isaac Z. ; Walmsley, Ryan S. ; Ugirinema, Vital ; Mnonopi, Nandipha O. ; Hosten, Eric ; Betz, Richard ; Frost, Carminita L. ; Tshentu, Zenixole R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-f78367cf999e84bbb423b8f6f12edc8a8d6f5edee20f13f703b4a13f7e8898773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>3T3-L1 Cells</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Animals</topic><topic>Anti-coagulative effects</topic><topic>Anti-diabetic effects</topic><topic>Anticoagulants - pharmacology</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Crystallography, X-Ray</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Glucose - metabolism</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Mice</topic><topic>Models, Chemical</topic><topic>Oxidovanadium(IV) complexes</topic><topic>Speciation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gundhla, Isaac Z.</creatorcontrib><creatorcontrib>Walmsley, Ryan S.</creatorcontrib><creatorcontrib>Ugirinema, Vital</creatorcontrib><creatorcontrib>Mnonopi, Nandipha O.</creatorcontrib><creatorcontrib>Hosten, Eric</creatorcontrib><creatorcontrib>Betz, Richard</creatorcontrib><creatorcontrib>Frost, Carminita L.</creatorcontrib><creatorcontrib>Tshentu, Zenixole R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gundhla, Isaac Z.</au><au>Walmsley, Ryan S.</au><au>Ugirinema, Vital</au><au>Mnonopi, Nandipha O.</au><au>Hosten, Eric</au><au>Betz, Richard</au><au>Frost, Carminita L.</au><au>Tshentu, Zenixole R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>145</volume><spage>11</spage><epage>18</epage><pages>11-18</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>A range of bidentate N,O-donor ligands of the imidazolyl-carboxylate moiety, which partially mimic naturally occurring bioligands, were prepared and reacted with the oxidovanadium(IV) ion to form the corresponding bis-coordinated oxidovanadium(IV) complexes. The aqueous pH-metric chemical speciation was investigated using glass electrode potentiometry, which allowed for the determination of protonation and stability constants of the ligands and complexes, respectively. The species distribution diagrams generated from this information gave evidence that the bis[(imidazolyl)carboxylato]oxovanadium(IV) complexes possess a broad pH-metric stability. The complexes improved glucose uptake in cell cultures using 3T3-L1 adipocytes, C2C12 muscle cells and Chang liver cells. The PTP inhibition studies indicated that the mechanism underlying insulin-stimulated glucose uptake was possibly via the protein tyrosine phosphorylation through the inhibition of the protein tyrosine phosphatase 1B (PTP 1B). The vanadium compounds also demonstrated the inhibition of D-dimer formation, suggesting that these compounds could potentially relieve a hypercoagulative state in diabetic patients.
The bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes show potential as anti-diabetic agents. [Display omitted]
•Oxidovanadium(IV) was stabilized by the imidazolyl-carboxylato moiety under physiological pH.•The isolated complexes were shown to activate glucose uptake in cell cultures.•The complexes showed inhibitory effect towards protein tyrosine phosphatase (PTP 1B).•The complexes also showed the inhibition of D-dimer formation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25594947</pmid><doi>10.1016/j.jinorgbio.2014.12.019</doi><tpages>8</tpages></addata></record> |
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subjects | 3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Animals Anti-coagulative effects Anti-diabetic effects Anticoagulants - pharmacology Coordination Complexes - chemistry Coordination Complexes - pharmacology Crystallography, X-Ray Enzyme Inhibitors - pharmacology Glucose - metabolism Hydrogen-Ion Concentration Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology In Vitro Techniques Mice Models, Chemical Oxidovanadium(IV) complexes Speciation |
title | pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes |
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