Suppression of choroidal neovascularization by Endostar in rats

Choroidal neovascularization (CNV) is common in various retinal and choroidal diseases, and may result in severe and irreversible loss of vision. Our previous studies suggested that Endostar, a novel recombinant endostatin, is able to inhibit the proliferation and migration of choroid-retinal endoth...

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Veröffentlicht in:	Molecular medicine reports 2015-05, Vol.11 (5), p.3621-3625
Hauptverfasser:	LIU, JIAN, YE, PANPAN, SU, ZHAOAN, LIN, KANA, HE, FENGYING, XU, WEN
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiography Animals Cell proliferation choroidal neovascularization Choroidal Neovascularization - drug therapy Choroidal Neovascularization - etiology Choroidal Neovascularization - pathology Cybernetics Down-Regulation Drug dosages drug therapy Endostatin Endostatins - pharmacology Endothelial cells Fluorescein Fluorescein Angiography Gene Expression Profiling Gene Expression Regulation - drug effects Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Leukocyte migration Male Neovascularization Neutrophils Patient outcomes Polymerase chain reaction Prevention Proteins Rats Recombinant molecules Retina Rodents Studies Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
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