Acquired somatic mutations of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) in preleukemic disorders

Mutations of isocitrate dehydrogenase isoform 1 and 2 (IDH1 and IDH2) genes have been identified in glioblastoma and acute myeloid leukemia (AML). However, little is known about the molecular alterations of IDH genes in preleukemic disorders with a propensity to transform to AML. We performed polyme...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 2015-03, Vol.54 (3), p.286-291
Hauptverfasser:	Chotirat, Sadudee, Thongnoppakhun, Wanna, Wanachiwanawin, Wanchai, Auewarakul, Chirayu U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anemia, Aplastic - genetics Aplastic anemia Base Sequence Cohort Studies Female Hemoglobinuria, Paroxysmal - genetics Humans IDH mutations Isocitrate Dehydrogenase - genetics Leukemia, Myeloid, Acute - genetics Male Middle Aged Mutation Myelodysplastic syndrome Myelodysplastic Syndromes - genetics Myeloproliferative Disorders - genetics Myeloproliferative neoplasms Paroxysmal nocturnal hemoglobinuria Polymorphism, Genetic Preleukemia disorders Young Adult
Online-Zugang:	Volltext
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