Super‐infection with Staphylococcus aureus inhibits influenza virus‐induced type I IFN signalling through impaired STAT1‐STAT2 dimerization

Summary Bacterial super‐infections are a major complication in influenza virus‐infected patients. In response to infection with influenza viruses and bacteria, a complex interplay of cellular signalling mechanisms is initiated, regulating the anti‐pathogen response but also pathogen‐supportive funct...

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Veröffentlicht in:	Cellular microbiology 2015-03, Vol.17 (3), p.303-317
Hauptverfasser:	Warnking, Kathrin, Klemm, Carolin, Löffler, Bettina, Niemann, Silke, Krüchten, Andre, Peters, Georg, Ludwig, Stephan, Ehrhardt, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cercopithecus aethiops Gene expression Host-Pathogen Interactions Humans Infections Influenza Interferon Type I - metabolism Orthomyxoviridae - immunology Orthomyxoviridae - physiology Protein Multimerization Staphylococcus aureus - immunology STAT1 Transcription Factor - metabolism STAT2 Transcription Factor - metabolism Virus Replication Viruses
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