Treatment‐free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide
Objective. To investigate the effect of an intensified treatment protocol synchronizing plasmapheresis with subsequent pulse cyclophosphamide for severe systemic lupus erythematosus (SLE). Methods. A protocol of plasmapheresis (3 x 60 ml/kg) and subsequent high‐dose pulse cyclophosphamide (36 mg/kg)...
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| Veröffentlicht in: | Arthritis and rheumatism 1994-12, Vol.37 (12), p.1784-1794 |
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| container_issue | 12 |
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| container_title | Arthritis and rheumatism |
| container_volume | 37 |
| creator | Euler, Hans H. Schroeder, Johann O. Harten, Pontus Zeuner, Rainald A. Gutschmidt, Hans J. |
| description | Objective. To investigate the effect of an intensified treatment protocol synchronizing plasmapheresis with subsequent pulse cyclophosphamide for severe systemic lupus erythematosus (SLE).
Methods. A protocol of plasmapheresis (3 x 60 ml/kg) and subsequent high‐dose pulse cyclophosphamide (36 mg/kg) followed by 6 months of peroral immunosuppression was used to treat 14 patients with severe SLE.
Results. Rapid improvement was achieved in all patients. Immunosuppressants, including corticosteroids, were withdrawn at month 6 in 12 patients. Eight patients continued without treatment for a mean observation period of 5.6 years (46–91 months).
Conclusion. The results demonstrate that treatment‐free clinical remission can be achieved in some patients with severe SLE. |
| doi_str_mv | 10.1002/art.1780371212 |
| format | Article |
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Methods. A protocol of plasmapheresis (3 x 60 ml/kg) and subsequent high‐dose pulse cyclophosphamide (36 mg/kg) followed by 6 months of peroral immunosuppression was used to treat 14 patients with severe SLE.
Results. Rapid improvement was achieved in all patients. Immunosuppressants, including corticosteroids, were withdrawn at month 6 in 12 patients. Eight patients continued without treatment for a mean observation period of 5.6 years (46–91 months).
Conclusion. The results demonstrate that treatment‐free clinical remission can be achieved in some patients with severe SLE.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780371212</identifier><identifier>PMID: 7986225</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Amenorrhea - physiopathology ; Biological and medical sciences ; Complement C4 - analysis ; Complement C4 - deficiency ; Creatinine - blood ; Cyclophosphamide - administration & dosage ; Cyclophosphamide - therapeutic use ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Immunoglobulins - metabolism ; Immunomodulators ; Kinetics ; Leukocyte Count ; Leukopenia - etiology ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - therapy ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Plasmapheresis ; Pregnancy ; Pregnancy Complications - physiopathology ; Pulsatile Flow ; Time Factors</subject><ispartof>Arthritis and rheumatism, 1994-12, Vol.37 (12), p.1784-1794</ispartof><rights>Copyright © 1994 American College of Rheumatology</rights><rights>1995 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4002-94030e2048a538b4ba2ea28e02839634cdb5a6359c8061177672fbfebfe52da93</citedby><cites>FETCH-LOGICAL-c4002-94030e2048a538b4ba2ea28e02839634cdb5a6359c8061177672fbfebfe52da93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780371212$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780371212$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27913,27914,45563,45564</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3338738$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7986225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Euler, Hans H.</creatorcontrib><creatorcontrib>Schroeder, Johann O.</creatorcontrib><creatorcontrib>Harten, Pontus</creatorcontrib><creatorcontrib>Zeuner, Rainald A.</creatorcontrib><creatorcontrib>Gutschmidt, Hans J.</creatorcontrib><title>Treatment‐free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective. To investigate the effect of an intensified treatment protocol synchronizing plasmapheresis with subsequent pulse cyclophosphamide for severe systemic lupus erythematosus (SLE).
Methods. A protocol of plasmapheresis (3 x 60 ml/kg) and subsequent high‐dose pulse cyclophosphamide (36 mg/kg) followed by 6 months of peroral immunosuppression was used to treat 14 patients with severe SLE.
Results. Rapid improvement was achieved in all patients. Immunosuppressants, including corticosteroids, were withdrawn at month 6 in 12 patients. Eight patients continued without treatment for a mean observation period of 5.6 years (46–91 months).
Conclusion. The results demonstrate that treatment‐free clinical remission can be achieved in some patients with severe SLE.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amenorrhea - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Complement C4 - analysis</subject><subject>Complement C4 - deficiency</subject><subject>Creatinine - blood</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunoglobulins - metabolism</subject><subject>Immunomodulators</subject><subject>Kinetics</subject><subject>Leukocyte Count</subject><subject>Leukopenia - etiology</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - therapy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmapheresis</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Pulsatile Flow</subject><subject>Time Factors</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo6-zq1ZuQg-ytx3z053FZVl1YEGQ8N-lMtR1Jd9pU2qE9-RP24C_0l1jLDKs3IRCq3idvVaUYeyXFVgqh3pqYtrKqha6kkuoJ28hCNZmQWj5lGyFEnumikc_ZOeJXCpUu9Bk7q5q6VKrYsF-7CCaNMKXfP-_7CMAjjA7RhYm7iSN8hwgcV0yUttwv84Ic4poGGE0KSFEfvA8HN30hbLJDDJP7YdKDQej57A2OZh7IBR3yg0sDx6VD-LZQTT4vHoHb1fowDwHnwYxuDy_Ys96Q8PJ0X7DP72521x-yu4_vb6-v7jKb0yRZkwstQIm8NoWuu7wzCoyqQahaN6XO7b4rTEnj21qUUlZVWam-64FOofam0Rfs8ug7x0D9YGppdAvemwnCgq0sC3KSmsDtEbQxIEbo2zm60cS1laJ9WENLa2j_roEevD45L90I-0f89O-kvznpBq3xfTSTdfiIaa3rSteENUfs4Dys_ynaXn3a_dPCH2JSpvE</recordid><startdate>199412</startdate><enddate>199412</enddate><creator>Euler, Hans H.</creator><creator>Schroeder, Johann O.</creator><creator>Harten, Pontus</creator><creator>Zeuner, Rainald A.</creator><creator>Gutschmidt, Hans J.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>199412</creationdate><title>Treatment‐free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide</title><author>Euler, Hans H. ; Schroeder, Johann O. ; Harten, Pontus ; Zeuner, Rainald A. ; Gutschmidt, Hans J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4002-94030e2048a538b4ba2ea28e02839634cdb5a6359c8061177672fbfebfe52da93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amenorrhea - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Complement C4 - analysis</topic><topic>Complement C4 - deficiency</topic><topic>Creatinine - blood</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunoglobulins - metabolism</topic><topic>Immunomodulators</topic><topic>Kinetics</topic><topic>Leukocyte Count</topic><topic>Leukopenia - etiology</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - therapy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasmapheresis</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Pulsatile Flow</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Euler, Hans H.</creatorcontrib><creatorcontrib>Schroeder, Johann O.</creatorcontrib><creatorcontrib>Harten, Pontus</creatorcontrib><creatorcontrib>Zeuner, Rainald A.</creatorcontrib><creatorcontrib>Gutschmidt, Hans J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Euler, Hans H.</au><au>Schroeder, Johann O.</au><au>Harten, Pontus</au><au>Zeuner, Rainald A.</au><au>Gutschmidt, Hans J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment‐free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1994-12</date><risdate>1994</risdate><volume>37</volume><issue>12</issue><spage>1784</spage><epage>1794</epage><pages>1784-1794</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>Objective. To investigate the effect of an intensified treatment protocol synchronizing plasmapheresis with subsequent pulse cyclophosphamide for severe systemic lupus erythematosus (SLE).
Methods. A protocol of plasmapheresis (3 x 60 ml/kg) and subsequent high‐dose pulse cyclophosphamide (36 mg/kg) followed by 6 months of peroral immunosuppression was used to treat 14 patients with severe SLE.
Results. Rapid improvement was achieved in all patients. Immunosuppressants, including corticosteroids, were withdrawn at month 6 in 12 patients. Eight patients continued without treatment for a mean observation period of 5.6 years (46–91 months).
Conclusion. The results demonstrate that treatment‐free clinical remission can be achieved in some patients with severe SLE.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>7986225</pmid><doi>10.1002/art.1780371212</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adolescent Adult Amenorrhea - physiopathology Biological and medical sciences Complement C4 - analysis Complement C4 - deficiency Creatinine - blood Cyclophosphamide - administration & dosage Cyclophosphamide - therapeutic use Dose-Response Relationship, Drug Female Follow-Up Studies Humans Immunoglobulins - metabolism Immunomodulators Kinetics Leukocyte Count Leukopenia - etiology Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - therapy Medical sciences Middle Aged Pharmacology. Drug treatments Plasmapheresis Pregnancy Pregnancy Complications - physiopathology Pulsatile Flow Time Factors |
| title | Treatment‐free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide |
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