Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests

The non-peptide NK-1 receptor antagonist, CP 96,345, has been evaluated for antinociceptive activity in two chemical pain models in the mouse. CP 96,345, injected intrathecally (i.t.) 5 min prior to 2.0% formalin, produced significant antinociception in both the early and late phases of the formalin...

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Veröffentlicht in:	Neuroscience letters 1993-03, Vol.151 (2), p.142-145
Hauptverfasser:	Sakurada, Tsukasa, Katsumata, Kazushige, Yogo, Hiromichi, Tan-No, Koichi, Sakurada, Shinobu, Kisara, Kensuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - administration & dosage Analgesics - pharmacology Animals Biological and medical sciences Biphenyl Compounds - administration & dosage Biphenyl Compounds - pharmacology Capsaicin CP 96,345 Dose-Response Relationship, Drug Formaldehyde Formalin Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - pharmacology Injections, Spinal Male Medical sciences Mice Mice, Inbred Strains Mouse Naloxone - pharmacology Neuropharmacology Pain - chemically induced Pain Measurement - drug effects Pharmacology. Drug treatments Postural Balance - drug effects Receptors, Neurokinin-2 Receptors, Neurotransmitter - antagonists & inhibitors Spinal cord Substance P - analogs & derivatives Substance P - pharmacology
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