TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE

Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been assessed. Menadione treatment of rats injected with DPI was associated with improved weight gain and increas...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 1992-08, Vol.115 (4), p.991-1000
Hauptverfasser:	COOPER, J. M., HAYES, D. J., CHALLISS, R. A. J., MORGAN-HUGHES, J. A., CLARK, J. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Animals Biological and medical sciences Biphenyl Compounds - administration & dosage Biphenyl Compounds - therapeutic use Drug Therapy, Combination Electron Transport Electron Transport Complex I Hindlimb Magnetic Resonance Spectroscopy Male Medical sciences Mitochondrial Myopathies - drug therapy Mitochondrial Myopathies - metabolism Muscle Muscles - metabolism NADH, NADPH Oxidoreductases - deficiency Onium Compounds - administration & dosage Onium Compounds - therapeutic use Pharmacology. Drug treatments Phosphates - metabolism Phosphocreatine - metabolism Rats Rats, Wistar Vitamin K - administration & dosage Vitamin K - therapeutic use
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