TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE
Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been assessed. Menadione treatment of rats injected with DPI was associated with improved weight gain and increas...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 1992-08, Vol.115 (4), p.991-1000 |
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| container_title | Brain (London, England : 1878) |
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| creator | COOPER, J. M. HAYES, D. J. CHALLISS, R. A. J. MORGAN-HUGHES, J. A. CLARK, J. B. |
| description | Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been assessed. Menadione treatment of rats injected with DPI was associated with improved weight gain and increased survival rate This was accompanied by an improvement in muscle function as judged by analysis of isometric twitch tension of the gastrocnemius muscle (1 Hz for 20 min). The decline in phosphocreatine (PCr) levels in the gastrocnemius muscle during stimulation and delayed recovery in PCr after stimulation were similar in the menadione treated and untreated models Menadione treatment of the DPI model resulted in a resting intramuscular pH significantly lower than control or untreated DPI rats, but a similar decline in intramuscular pH to the DPI rats during stimulation. The changes in metabolite levels were broadly similar in both the menadione treated and untreated DPI models following stimulation, although the changes, except for increased lactate concentration, were generally less marked in the menadione-treated DPI model |
| doi_str_mv | 10.1093/brain/115.4.991 |
| format | Article |
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M. ; HAYES, D. J. ; CHALLISS, R. A. J. ; MORGAN-HUGHES, J. A. ; CLARK, J. B.</creator><creatorcontrib>COOPER, J. M. ; HAYES, D. J. ; CHALLISS, R. A. J. ; MORGAN-HUGHES, J. A. ; CLARK, J. B.</creatorcontrib><description>Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been assessed. Menadione treatment of rats injected with DPI was associated with improved weight gain and increased survival rate This was accompanied by an improvement in muscle function as judged by analysis of isometric twitch tension of the gastrocnemius muscle (1 Hz for 20 min). The decline in phosphocreatine (PCr) levels in the gastrocnemius muscle during stimulation and delayed recovery in PCr after stimulation were similar in the menadione treated and untreated models Menadione treatment of the DPI model resulted in a resting intramuscular pH significantly lower than control or untreated DPI rats, but a similar decline in intramuscular pH to the DPI rats during stimulation. 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Drug treatments ; Phosphates - metabolism ; Phosphocreatine - metabolism ; Rats ; Rats, Wistar ; Vitamin K - administration & dosage ; Vitamin K - therapeutic use</subject><ispartof>Brain (London, England : 1878), 1992-08, Vol.115 (4), p.991-1000</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-28e15d4c8e4a18f3f31f79d848765723b2546b3f2e65b11ddddc95194e6a015c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4347846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1393515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COOPER, J. M.</creatorcontrib><creatorcontrib>HAYES, D. J.</creatorcontrib><creatorcontrib>CHALLISS, R. A. J.</creatorcontrib><creatorcontrib>MORGAN-HUGHES, J. A.</creatorcontrib><creatorcontrib>CLARK, J. B.</creatorcontrib><title>TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been assessed. Menadione treatment of rats injected with DPI was associated with improved weight gain and increased survival rate This was accompanied by an improvement in muscle function as judged by analysis of isometric twitch tension of the gastrocnemius muscle (1 Hz for 20 min). The decline in phosphocreatine (PCr) levels in the gastrocnemius muscle during stimulation and delayed recovery in PCr after stimulation were similar in the menadione treated and untreated models Menadione treatment of the DPI model resulted in a resting intramuscular pH significantly lower than control or untreated DPI rats, but a similar decline in intramuscular pH to the DPI rats during stimulation. The changes in metabolite levels were broadly similar in both the menadione treated and untreated DPI models following stimulation, although the changes, except for increased lactate concentration, were generally less marked in the menadione-treated DPI model</description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biphenyl Compounds - administration & dosage</subject><subject>Biphenyl Compounds - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Electron Transport</subject><subject>Electron Transport Complex I</subject><subject>Hindlimb</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mitochondrial Myopathies - drug therapy</subject><subject>Mitochondrial Myopathies - metabolism</subject><subject>Muscle</subject><subject>Muscles - metabolism</subject><subject>NADH, NADPH Oxidoreductases - deficiency</subject><subject>Onium Compounds - administration & dosage</subject><subject>Onium Compounds - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphates - metabolism</subject><subject>Phosphocreatine - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vitamin K - administration & dosage</subject><subject>Vitamin K - therapeutic use</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAQRi0EgrKcOSHlgLil9cRL4mNIXRrUprSkYrlYTupIgW7ErQT_HkMrmMto9L1vDg-hS8BtwIJ0ikbXyw4Aa9O2EHCAWkA59gNg_BC1MMbcjwTDJ-jU2jeMgZKAH6NjIIIwYC00zCcyzocyy71Rz5PPD3KS_lzxwMvibt-b3qbjaZqNMulNZHea5PGj9LqylyapzJIX7ynN-54rxN3UMefoqNJzay72-wxNezJP-v5gdJcm8cAvCRMbP4gMsBktI0M1RBWpCFShmEU0CjkLA1IEjPKCVIHhrACYuSkFA0EN1xhYSc7Qze7vull9bI3dqEVtSzOf66VZba0CzqIgINiBnR1YNitrG1OpdVMvdPOlAKsfgepXoHICFVVOoGtc7V9vi4WZ_fM7Yy6_3ufalnpeNXpZ1vYPo4SGEeUO83dYbTfm8y_WzbviIQmZ6j-_Kjp-vc_xfeha3_LDgKU</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>COOPER, J. M.</creator><creator>HAYES, D. J.</creator><creator>CHALLISS, R. A. J.</creator><creator>MORGAN-HUGHES, J. A.</creator><creator>CLARK, J. B.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19920801</creationdate><title>TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE</title><author>COOPER, J. M. ; HAYES, D. J. ; CHALLISS, R. A. J. ; MORGAN-HUGHES, J. A. ; CLARK, J. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-28e15d4c8e4a18f3f31f79d848765723b2546b3f2e65b11ddddc95194e6a015c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adenosine Diphosphate - metabolism</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biphenyl Compounds - administration & dosage</topic><topic>Biphenyl Compounds - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Electron Transport</topic><topic>Electron Transport Complex I</topic><topic>Hindlimb</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mitochondrial Myopathies - drug therapy</topic><topic>Mitochondrial Myopathies - metabolism</topic><topic>Muscle</topic><topic>Muscles - metabolism</topic><topic>NADH, NADPH Oxidoreductases - deficiency</topic><topic>Onium Compounds - administration & dosage</topic><topic>Onium Compounds - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphates - metabolism</topic><topic>Phosphocreatine - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vitamin K - administration & dosage</topic><topic>Vitamin K - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COOPER, J. M.</creatorcontrib><creatorcontrib>HAYES, D. J.</creatorcontrib><creatorcontrib>CHALLISS, R. A. J.</creatorcontrib><creatorcontrib>MORGAN-HUGHES, J. A.</creatorcontrib><creatorcontrib>CLARK, J. 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B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>115</volume><issue>4</issue><spage>991</spage><epage>1000</epage><pages>991-1000</pages><issn>0006-8950</issn><eissn>1460-2156</eissn><abstract>Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been assessed. Menadione treatment of rats injected with DPI was associated with improved weight gain and increased survival rate This was accompanied by an improvement in muscle function as judged by analysis of isometric twitch tension of the gastrocnemius muscle (1 Hz for 20 min). The decline in phosphocreatine (PCr) levels in the gastrocnemius muscle during stimulation and delayed recovery in PCr after stimulation were similar in the menadione treated and untreated models Menadione treatment of the DPI model resulted in a resting intramuscular pH significantly lower than control or untreated DPI rats, but a similar decline in intramuscular pH to the DPI rats during stimulation. The changes in metabolite levels were broadly similar in both the menadione treated and untreated DPI models following stimulation, although the changes, except for increased lactate concentration, were generally less marked in the menadione-treated DPI model</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>1393515</pmid><doi>10.1093/brain/115.4.991</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain (London, England : 1878), 1992-08, Vol.115 (4), p.991-1000 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Animals Biological and medical sciences Biphenyl Compounds - administration & dosage Biphenyl Compounds - therapeutic use Drug Therapy, Combination Electron Transport Electron Transport Complex I Hindlimb Magnetic Resonance Spectroscopy Male Medical sciences Mitochondrial Myopathies - drug therapy Mitochondrial Myopathies - metabolism Muscle Muscles - metabolism NADH, NADPH Oxidoreductases - deficiency Onium Compounds - administration & dosage Onium Compounds - therapeutic use Pharmacology. Drug treatments Phosphates - metabolism Phosphocreatine - metabolism Rats Rats, Wistar Vitamin K - administration & dosage Vitamin K - therapeutic use |
| title | TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE |
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