Detection of Tumor-derived DNA in Cerebrospinal Fluid

The sensitivity of PCR-based methods for the detection of DNA offers opportunities for tumor diagnosis from the small amounts of tumor-derived DNA released into body fluids. We report the detection of tumor DNA in the cerebrospinal fluid (CSF) of two patients with intracranial neoplasms. One patient...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 1994-07, Vol.53 (4), p.364-368
Hauptverfasser:	Rhodes, C Harker, Honsinger, Charles, Sorenson, George D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Brain Neoplasms - cerebrospinal fluid Brain Neoplasms - secondary Breast Neoplasms - cerebrospinal fluid Breast Neoplasms - pathology Carcinoma, Ductal, Breast - cerebrospinal fluid Carcinoma, Ductal, Breast - secondary Cerebrospinal fluid (biochemistry, cytology, circulation, manometry). Intracranial pressure determination DNA, Neoplasm - cerebrospinal fluid ErbB Receptors - genetics Female Gene Amplification Glioblastoma - cerebrospinal fluid Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Proto-Oncogene Proteins - genetics Receptor, ErbB-2
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