Near-tetraploid poorly differentiated acute myeloid leukemia M0 diagnosed by short-term cultures with a Phorbol ester TPA
Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14–30 μm in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed...
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| Veröffentlicht in: | Leukemia research 1994-07, Vol.18 (7), p.493-497 |
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| creator | Lemeẑ, Petr Jelínek, Jaroslav Michalová, Kyra Koubek, Kristián Schwarz, Jiŕí Malasková, Vêra Rypáčková, Blanka Jirásek, Adam Březinová, Jana Hrabánek, Jan Vítek, Antonín |
| description | Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14–30 μm in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetraploid karyotype. Blasts from both patients differentiated into macrophages in cultures with 10 ng/ml 12-
O-tetradecanoylphorbol-13-acetate (TPA) which is a feature specific for myeloid blasts and the cases were thus classified as poorly differentiated acute myeloid leukemias (AML M0). Near-tetraploid poorly differentiated acute myeloid leukemias M0 seem to be a special category of AML in the morphologic, immunologic and cytogenetic (MIC) classification. The presence of very large blasts in the heterogeneous blast population in acute unclassified leukemias could be a morphological sign of near-tetraploid leukemias AML M0. |
| doi_str_mv | 10.1016/0145-2126(94)90087-6 |
| format | Article |
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O-tetradecanoylphorbol-13-acetate (TPA) which is a feature specific for myeloid blasts and the cases were thus classified as poorly differentiated acute myeloid leukemias (AML M0). Near-tetraploid poorly differentiated acute myeloid leukemias M0 seem to be a special category of AML in the morphologic, immunologic and cytogenetic (MIC) classification. The presence of very large blasts in the heterogeneous blast population in acute unclassified leukemias could be a morphological sign of near-tetraploid leukemias AML M0.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(94)90087-6</identifier><identifier>PMID: 8022200</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aged ; Biological and medical sciences ; Cell Differentiation - drug effects ; DNA, Neoplasm - analysis ; Female ; Hematologic and hematopoietic diseases ; Humans ; Immunophenotyping ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; MIC classification ; Middle Aged ; near-tetraploid leukemia ; phorbol ester TPA ; Polyploidy ; short-term cultures ; Tetradecanoylphorbol Acetate - pharmacology ; Undifferentiated acute myeloid leukemia M0</subject><ispartof>Leukemia research, 1994-07, Vol.18 (7), p.493-497</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-a1123ea38a1af413bbde4e92ca6e1c6654e4dc0ad4c2f0d2cc11eaaf0f1244bf3</citedby><cites>FETCH-LOGICAL-c446t-a1123ea38a1af413bbde4e92ca6e1c6654e4dc0ad4c2f0d2cc11eaaf0f1244bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0145-2126(94)90087-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4173620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8022200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lemeẑ, Petr</creatorcontrib><creatorcontrib>Jelínek, Jaroslav</creatorcontrib><creatorcontrib>Michalová, Kyra</creatorcontrib><creatorcontrib>Koubek, Kristián</creatorcontrib><creatorcontrib>Schwarz, Jiŕí</creatorcontrib><creatorcontrib>Malasková, Vêra</creatorcontrib><creatorcontrib>Rypáčková, Blanka</creatorcontrib><creatorcontrib>Jirásek, Adam</creatorcontrib><creatorcontrib>Březinová, Jana</creatorcontrib><creatorcontrib>Hrabánek, Jan</creatorcontrib><creatorcontrib>Vítek, Antonín</creatorcontrib><title>Near-tetraploid poorly differentiated acute myeloid leukemia M0 diagnosed by short-term cultures with a Phorbol ester TPA</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14–30 μm in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetraploid karyotype. Blasts from both patients differentiated into macrophages in cultures with 10 ng/ml 12-
O-tetradecanoylphorbol-13-acetate (TPA) which is a feature specific for myeloid blasts and the cases were thus classified as poorly differentiated acute myeloid leukemias (AML M0). Near-tetraploid poorly differentiated acute myeloid leukemias M0 seem to be a special category of AML in the morphologic, immunologic and cytogenetic (MIC) classification. The presence of very large blasts in the heterogeneous blast population in acute unclassified leukemias could be a morphological sign of near-tetraploid leukemias AML M0.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MIC classification</subject><subject>Middle Aged</subject><subject>near-tetraploid leukemia</subject><subject>phorbol ester TPA</subject><subject>Polyploidy</subject><subject>short-term cultures</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Undifferentiated acute myeloid leukemia M0</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EKkvhH4DkA0JwCNiO400uSFXFl1Sgh3K2JvaYGpx4azug_Hu83dUeOc3hfead0UPIc87ecsbVO8Zl1wgu1OtBvhkY67eNekA2vN-2Tde33UOyOSGPyZOcfzHGuoEPZ-SsZ0IIxjZk_YaQmoIlwS5Eb-kuxhRWar1zmHAuHgpaCmYpSKcV75mAy2-cPNCvrILwc465MuNK821MpbaliZollCVhpn99uaVAr2s0xkAx15jeXF88JY8chIzPjvOc_Pj44ebyc3P1_dOXy4urxkipSgOcixah7YGDk7wdR4sSB2FAITdKdRKlNQysNMIxK4zhHAEcc1xIObr2nLw69O5SvFvqeT35bDAEmDEuWXPVbXvJZQXlATQp5pzQ6V3yE6RVc6b3xvVep97r1IPU98a1qmsvjv3LOKE9LR0V1_zlMYdsILgEs_H5hEm-bZXYY-8PGFYXfzwmnY3H2aD1CU3RNvr___EPvIae8Q</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Lemeẑ, Petr</creator><creator>Jelínek, Jaroslav</creator><creator>Michalová, Kyra</creator><creator>Koubek, Kristián</creator><creator>Schwarz, Jiŕí</creator><creator>Malasková, Vêra</creator><creator>Rypáčková, Blanka</creator><creator>Jirásek, Adam</creator><creator>Březinová, Jana</creator><creator>Hrabánek, Jan</creator><creator>Vítek, Antonín</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19940701</creationdate><title>Near-tetraploid poorly differentiated acute myeloid leukemia M0 diagnosed by short-term cultures with a Phorbol ester TPA</title><author>Lemeẑ, Petr ; Jelínek, Jaroslav ; Michalová, Kyra ; Koubek, Kristián ; Schwarz, Jiŕí ; Malasková, Vêra ; Rypáčková, Blanka ; Jirásek, Adam ; Březinová, Jana ; Hrabánek, Jan ; Vítek, Antonín</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-a1123ea38a1af413bbde4e92ca6e1c6654e4dc0ad4c2f0d2cc11eaaf0f1244bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Leukemia, Myeloid, Acute - diagnosis</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MIC classification</topic><topic>Middle Aged</topic><topic>near-tetraploid leukemia</topic><topic>phorbol ester TPA</topic><topic>Polyploidy</topic><topic>short-term cultures</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Undifferentiated acute myeloid leukemia M0</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lemeẑ, Petr</creatorcontrib><creatorcontrib>Jelínek, Jaroslav</creatorcontrib><creatorcontrib>Michalová, Kyra</creatorcontrib><creatorcontrib>Koubek, Kristián</creatorcontrib><creatorcontrib>Schwarz, Jiŕí</creatorcontrib><creatorcontrib>Malasková, Vêra</creatorcontrib><creatorcontrib>Rypáčková, Blanka</creatorcontrib><creatorcontrib>Jirásek, Adam</creatorcontrib><creatorcontrib>Březinová, Jana</creatorcontrib><creatorcontrib>Hrabánek, Jan</creatorcontrib><creatorcontrib>Vítek, Antonín</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lemeẑ, Petr</au><au>Jelínek, Jaroslav</au><au>Michalová, Kyra</au><au>Koubek, Kristián</au><au>Schwarz, Jiŕí</au><au>Malasková, Vêra</au><au>Rypáčková, Blanka</au><au>Jirásek, Adam</au><au>Březinová, Jana</au><au>Hrabánek, Jan</au><au>Vítek, Antonín</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Near-tetraploid poorly differentiated acute myeloid leukemia M0 diagnosed by short-term cultures with a Phorbol ester TPA</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>18</volume><issue>7</issue><spage>493</spage><epage>497</epage><pages>493-497</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14–30 μm in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetraploid karyotype. Blasts from both patients differentiated into macrophages in cultures with 10 ng/ml 12-
O-tetradecanoylphorbol-13-acetate (TPA) which is a feature specific for myeloid blasts and the cases were thus classified as poorly differentiated acute myeloid leukemias (AML M0). Near-tetraploid poorly differentiated acute myeloid leukemias M0 seem to be a special category of AML in the morphologic, immunologic and cytogenetic (MIC) classification. The presence of very large blasts in the heterogeneous blast population in acute unclassified leukemias could be a morphological sign of near-tetraploid leukemias AML M0.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8022200</pmid><doi>10.1016/0145-2126(94)90087-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Leukemia research, 1994-07, Vol.18 (7), p.493-497 |
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| language | eng |
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| subjects | Aged Biological and medical sciences Cell Differentiation - drug effects DNA, Neoplasm - analysis Female Hematologic and hematopoietic diseases Humans Immunophenotyping Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences MIC classification Middle Aged near-tetraploid leukemia phorbol ester TPA Polyploidy short-term cultures Tetradecanoylphorbol Acetate - pharmacology Undifferentiated acute myeloid leukemia M0 |
| title | Near-tetraploid poorly differentiated acute myeloid leukemia M0 diagnosed by short-term cultures with a Phorbol ester TPA |
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