VE1 Antibody Is Not Highly Specific for the BRAF V600E Mutation in Thyroid Cytology Categories With the Exception of Malignant Cases

Objectives: We evaluated the utility of the VE1 antibody that can detect a mutant protein resulting from the BRAF V600E mutation as a diagnostic tool for thyroid fine-needle aspiration cytology (FNAC). Methods: We performed VE1 immunocytochemistry on 202 FNAC specimens from surgically confirmed thyr...

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Veröffentlicht in:	American journal of clinical pathology 2015-03, Vol.143 (3), p.437-444
Hauptverfasser:	Lee, Sang-Ryung, Yim, Hyunee, Han, Jae Ho, Lee, Kyi Beom, Lee, Jeonghun, Soh, Euy Young, Kim, Dae Jung, Chung, Yoon-Sok, Jeong, Seon-Yong, Sheen, Seung Soo, Park, So Hyun, Kim, Jang-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antibodies, Monoclonal Biopsy, Fine-Needle Carcinoma, Papillary - pathology DNA Mutational Analysis False Positive Reactions Humans Immunohistochemistry Mice Mutation Predictive Value of Tests Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Sensitivity and Specificity Thyroid Neoplasms - pathology Thyroid Nodule - pathology
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