Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on “how PBPK modeling can be applie...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical pharmacology and therapeutics 2015-03, Vol.97 (3), p.247-262
Hauptverfasser: Jones, HM, Chen, Y, Gibson, C, Heimbach, T, Parrott, N, Peters, SA, Snoeys, J, Upreti, VV, Zheng, M, Hall, SD
Format: Artikel
Sprache:eng
Schlagworte:
Drug Approval
Drug Discovery - methods
Drug Industry - methods
Humans
Models, Biological
Pharmacokinetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 262
container_issue 3
container_start_page 247
container_title Clinical pharmacology and therapeutics
container_volume 97
creator Jones, HM
Chen, Y
Gibson, C
Heimbach, T
Parrott, N
Peters, SA
Snoeys, J
Upreti, VV
Zheng, M
Hall, SD
description The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on “how PBPK modeling can be applied in industry” focusing on the strategies for application of PBPK at different stages, an associated perspective on the confidence and challenges, as well as guidance on interacting with regulatory agencies and internal best practices.
doi_str_mv 10.1002/cpt.37
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1657324791</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1657324791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4177-deb578cd96a2a6e5c07467e5e9f2fb02b31226039f59e598913b9d10646d96403</originalsourceid><addsrcrecordid>eNp1kM1u1DAURi0EosMAj4CyQrBI8U9sj9lVI1qQKuhiEOwsx76ZmjpxsJMpeXtcpu2OlXWlc46sD6HXBJ8SjOkHO06nTD5BK8IZrQVn_ClaYYxVrSgTJ-hFzr_K2ajN5jk6oVxITLFaodur6yX7GOLeWxPCUrUmg6vGa5N6Y-ONH2Dytuqjg-CHfeWHyqV5XzmfbTxAWiozuMrBAUIceximj9XZgw3zdBctjpvzVNARUh7BTv4AL9GzzoQMr-7fNfp-_mm3_Vxffrv4sj27rG1DpKwdtFxurFPCUCOAWywbIYGD6mjXYtoyQqnATHVcAVcbRVirHMGiEcVpMFujd8fumOLvGfKk-_JzCMEMEOesieCS0UYWcY3eHlGbYs4JOj0m35u0aIL13ci6jKyZLOCb--bc9uAesYdVC_D-CNz6AMt_Mnp7tfsXq4-szxP8eWRNutFCMsn1j68X-lwq-XO3w5qzvyVIleg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1657324791</pqid></control><display><type>article</type><title>Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jones, HM ; Chen, Y ; Gibson, C ; Heimbach, T ; Parrott, N ; Peters, SA ; Snoeys, J ; Upreti, VV ; Zheng, M ; Hall, SD</creator><creatorcontrib>Jones, HM ; Chen, Y ; Gibson, C ; Heimbach, T ; Parrott, N ; Peters, SA ; Snoeys, J ; Upreti, VV ; Zheng, M ; Hall, SD</creatorcontrib><description>The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on “how PBPK modeling can be applied in industry” focusing on the strategies for application of PBPK at different stages, an associated perspective on the confidence and challenges, as well as guidance on interacting with regulatory agencies and internal best practices.</description><identifier>ISSN: 0009-9236</identifier><identifier>EISSN: 1532-6535</identifier><identifier>DOI: 10.1002/cpt.37</identifier><identifier>PMID: 25670209</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Drug Approval ; Drug Discovery - methods ; Drug Industry - methods ; Humans ; Models, Biological ; Pharmacokinetics</subject><ispartof>Clinical pharmacology and therapeutics, 2015-03, Vol.97 (3), p.247-262</ispartof><rights>2014 American Society for Clinical Pharmacology and Therapeutics</rights><rights>2014 American Society for Clinical Pharmacology and Therapeutics.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4177-deb578cd96a2a6e5c07467e5e9f2fb02b31226039f59e598913b9d10646d96403</citedby><cites>FETCH-LOGICAL-c4177-deb578cd96a2a6e5c07467e5e9f2fb02b31226039f59e598913b9d10646d96403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcpt.37$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcpt.37$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25670209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, HM</creatorcontrib><creatorcontrib>Chen, Y</creatorcontrib><creatorcontrib>Gibson, C</creatorcontrib><creatorcontrib>Heimbach, T</creatorcontrib><creatorcontrib>Parrott, N</creatorcontrib><creatorcontrib>Peters, SA</creatorcontrib><creatorcontrib>Snoeys, J</creatorcontrib><creatorcontrib>Upreti, VV</creatorcontrib><creatorcontrib>Zheng, M</creatorcontrib><creatorcontrib>Hall, SD</creatorcontrib><title>Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective</title><title>Clinical pharmacology and therapeutics</title><addtitle>Clin. Pharmacol. Ther</addtitle><description>The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on “how PBPK modeling can be applied in industry” focusing on the strategies for application of PBPK at different stages, an associated perspective on the confidence and challenges, as well as guidance on interacting with regulatory agencies and internal best practices.</description><subject>Drug Approval</subject><subject>Drug Discovery - methods</subject><subject>Drug Industry - methods</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Pharmacokinetics</subject><issn>0009-9236</issn><issn>1532-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u1DAURi0EosMAj4CyQrBI8U9sj9lVI1qQKuhiEOwsx76ZmjpxsJMpeXtcpu2OlXWlc46sD6HXBJ8SjOkHO06nTD5BK8IZrQVn_ClaYYxVrSgTJ-hFzr_K2ajN5jk6oVxITLFaodur6yX7GOLeWxPCUrUmg6vGa5N6Y-ONH2Dytuqjg-CHfeWHyqV5XzmfbTxAWiozuMrBAUIceximj9XZgw3zdBctjpvzVNARUh7BTv4AL9GzzoQMr-7fNfp-_mm3_Vxffrv4sj27rG1DpKwdtFxurFPCUCOAWywbIYGD6mjXYtoyQqnATHVcAVcbRVirHMGiEcVpMFujd8fumOLvGfKk-_JzCMEMEOesieCS0UYWcY3eHlGbYs4JOj0m35u0aIL13ci6jKyZLOCb--bc9uAesYdVC_D-CNz6AMt_Mnp7tfsXq4-szxP8eWRNutFCMsn1j68X-lwq-XO3w5qzvyVIleg</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Jones, HM</creator><creator>Chen, Y</creator><creator>Gibson, C</creator><creator>Heimbach, T</creator><creator>Parrott, N</creator><creator>Peters, SA</creator><creator>Snoeys, J</creator><creator>Upreti, VV</creator><creator>Zheng, M</creator><creator>Hall, SD</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective</title><author>Jones, HM ; Chen, Y ; Gibson, C ; Heimbach, T ; Parrott, N ; Peters, SA ; Snoeys, J ; Upreti, VV ; Zheng, M ; Hall, SD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4177-deb578cd96a2a6e5c07467e5e9f2fb02b31226039f59e598913b9d10646d96403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Drug Approval</topic><topic>Drug Discovery - methods</topic><topic>Drug Industry - methods</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, HM</creatorcontrib><creatorcontrib>Chen, Y</creatorcontrib><creatorcontrib>Gibson, C</creatorcontrib><creatorcontrib>Heimbach, T</creatorcontrib><creatorcontrib>Parrott, N</creatorcontrib><creatorcontrib>Peters, SA</creatorcontrib><creatorcontrib>Snoeys, J</creatorcontrib><creatorcontrib>Upreti, VV</creatorcontrib><creatorcontrib>Zheng, M</creatorcontrib><creatorcontrib>Hall, SD</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, HM</au><au>Chen, Y</au><au>Gibson, C</au><au>Heimbach, T</au><au>Parrott, N</au><au>Peters, SA</au><au>Snoeys, J</au><au>Upreti, VV</au><au>Zheng, M</au><au>Hall, SD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clin. Pharmacol. Ther</addtitle><date>2015-03</date><risdate>2015</risdate><volume>97</volume><issue>3</issue><spage>247</spage><epage>262</epage><pages>247-262</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><abstract>The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on “how PBPK modeling can be applied in industry” focusing on the strategies for application of PBPK at different stages, an associated perspective on the confidence and challenges, as well as guidance on interacting with regulatory agencies and internal best practices.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25670209</pmid><doi>10.1002/cpt.37</doi><tpages>16</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0009-9236
ispartof Clinical pharmacology and therapeutics, 2015-03, Vol.97 (3), p.247-262
issn 0009-9236
1532-6535
language eng
recordid cdi_proquest_miscellaneous_1657324791
source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Drug Approval
Drug Discovery - methods
Drug Industry - methods
Humans
Models, Biological
Pharmacokinetics
title Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T06%3A13%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physiologically%20based%20pharmacokinetic%20modeling%20in%20drug%20discovery%20and%20development:%20A%20pharmaceutical%20industry%20perspective&rft.jtitle=Clinical%20pharmacology%20and%20therapeutics&rft.au=Jones,%20HM&rft.date=2015-03&rft.volume=97&rft.issue=3&rft.spage=247&rft.epage=262&rft.pages=247-262&rft.issn=0009-9236&rft.eissn=1532-6535&rft_id=info:doi/10.1002/cpt.37&rft_dat=%3Cproquest_cross%3E1657324791%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1657324791&rft_id=info:pmid/25670209&rfr_iscdi=true