Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes

Current classification of head and neck squamous cell carcinomas (HNSCC) based on anatomic site and stage fails to capture biologic heterogeneity or adequately inform treatment. Here, we use gene expression-based consensus clustering, copy number profiling, and human papillomavirus (HPV) status on a...

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Veröffentlicht in:	Clinical cancer research 2015-02, Vol.21 (4), p.870-881
Hauptverfasser:	Keck, Michaela K, Zuo, Zhixiang, Khattri, Arun, Stricker, Thomas P, Brown, Christopher D, Imanguli, Matin, Rieke, Damian, Endhardt, Katharina, Fang, Petra, Brägelmann, Johannes, DeBoer, Rebecca, El-Dinali, Mohamed, Aktolga, Serdal, Lei, Zhengdeng, Tan, Patrick, Rozen, Steve G, Salgia, Ravi, Weichselbaum, Ralph R, Lingen, Mark W, Story, Michael D, Ang, K Kian, Cohen, Ezra E W, White, Kevin P, Vokes, Everett E, Seiwert, Tanguy Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Squamous Cell - classification Carcinoma, Squamous Cell - virology Head and Neck Neoplasms - classification Head and Neck Neoplasms - virology Humans Papillomaviridae Papillomavirus Infections - complications Squamous Cell Carcinoma of Head and Neck
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