Bromoalkaloids Protect Primary Cortical Neurons from Induced Oxidative Stress

Bromoalkaloids are secondary metabolites with a demonstrated high activity in several therapeutic areas. In this research, we probe the neuroprotective and antioxidant activities of hymenialdisine and hymenin. Both structures were tested in an oxidative stress cellular model, consisting of cortical...

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Veröffentlicht in:	ACS chemical neuroscience 2015-02, Vol.6 (2), p.331-338
Hauptverfasser:	Leirós, M, Alonso, E, Rateb, M. E, Houssen, W. E, Ebel, R, Jaspars, M, Alfonso, A, Botana, L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - pharmacology Animals Antioxidant Response Elements - physiology Azepines - chemistry Azepines - pharmacology Blotting, Western Cell Membrane - drug effects Cell Membrane - metabolism Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - pathology Cerebral Cortex - physiology Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Mice Microscopy, Confocal Mitochondria - drug effects Mitochondria - metabolism Neurons - drug effects Neurons - pathology Neurons - physiology Neuroprotective Agents - pharmacology NF-E2-Related Factor 2 - metabolism Oxidative Stress - drug effects Oxidative Stress - physiology Pyrroles - chemistry Pyrroles - pharmacology Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Signal Transduction - drug effects
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