Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors

Baicalin and scutellarin are the principal bioactive components of Scutellaria baicalensis Georgi which has extensively been incorporated into heat-clearing and detoxification formulas for the treatment of Helicobacter pylori-related gastrointestinal disorders in traditional Chinese medicine. Howeve...

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Veröffentlicht in:	Journal of ethnopharmacology 2015-03, Vol.162, p.69-78
Hauptverfasser:	Yu, Xiao-Dan, Zheng, Rong-Bo, Xie, Jian-Hui, Su, Ji-Yan, Huang, Xiao-Qi, Wang, Yong-Hong, Zheng, Yi-Feng, Mo, Zhi-Zhun, Wu, Xiao-Li, Wu, Dian-Wei, Liang, Ye-er, Zeng, Hui-Fang, Su, Zi-Ren, Huang, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Apigenin - chemistry Apigenin - pharmacology Baicalin Cell Line Cell Survival - drug effects Flavonoids - chemistry Flavonoids - pharmacology Glucuronates - chemistry Glucuronates - pharmacology Helicobacter pylori Helicobacter pylori - enzymology Humans Molecular docking Molecular Docking Simulation Non-competitive inhibitior Scutellarin Urease Urease - antagonists & inhibitors Urease - chemistry Urease - metabolism
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