Critical issues for Klebsiella pneumoniae KPC-carbapenemase producing K. pneumoniae infections: a critical agenda
The wide dissemination of carbapenemase producing K. pneumoniae (KPC-Kp) has caused a public health crisis of global dimensions, due to the serious infections in hospitalized patients associated with high mortality. In 2014, we aim to review clinical data on KPC-Kp at a time when a pro-active strate...
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| Veröffentlicht in: | Future microbiology 2015-02, Vol.10 (2), p.283-294 |
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| creator | De Rosa, Francesco G Corcione, Silvia Cavallo, Rossana Di Perri, Giovanni Bassetti, Matteo |
| description | The wide dissemination of carbapenemase producing K. pneumoniae (KPC-Kp) has caused a public health crisis of global dimensions, due to the serious infections in hospitalized patients associated with high mortality. In 2014, we aim to review clinical data on KPC-Kp at a time when a pro-active strategy (combating the problem before it is established) is no longer useful, focusing on epidemiology, patient risk profile, infection control, digestive tract colonization and treatment issues such as the role of carbapenems or carbapenem sparing strategies, colistin and resistance, dual carbapenem administration and the role of tigecycline. All these issues are illustrated prospectively to provide a forum for a Consensus strategy when not only intensive care units but also medical and surgical wards are affected by the epidemics. |
| doi_str_mv | 10.2217/fmb.14.121 |
| format | Article |
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| subjects | Anti-Bacterial Agents - therapeutic use Bacterial Proteins - biosynthesis beta-Lactamases - biosynthesis Carbapenems - therapeutic use Care and treatment Colistin - therapeutic use Cross Infection - drug therapy Cross Infection - epidemiology Drug Therapy, Computer-Assisted Epidemiology Hospitals Humans Infection Control Klebsiella Klebsiella infections Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Microbiological research Minocycline - analogs & derivatives Minocycline - therapeutic use Mortality Prevention Risk Factors Studies |
| title | Critical issues for Klebsiella pneumoniae KPC-carbapenemase producing K. pneumoniae infections: a critical agenda |
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