Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats
We previously found that low-dose X-ray irradiation or radon (weak α-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbit. In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of t...
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| Veröffentlicht in: | Free radical biology & medicine 1994-04, Vol.16 (4), p.529-534 |
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| creator | Yamaoka, Kiyonri Edamatsu, Rei Itoh, Takehiko Akitane, Mori |
| description | We previously found that low-dose X-ray irradiation or radon (weak α-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbit. In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of the cerebral cortex in aged male Wistar rats (65 and 91 weeks old) were affected by low-dose X-ray irradiation (100 cGy or under) compared with those in 7-week-old rats, to elucidate the mechanism of aging inhibition. The following results were obtained: Although radiation sensitivity was observed to decreases with age, low-dose irradiation changed the Mn-SOD activity, lipid peroxide level, and membrane protein fluidity parameter of the cerebral cortex in the aged rats to be closer to those in the youth. These finding suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity. |
| doi_str_mv | 10.1016/0891-5849(94)90132-5 |
| format | Article |
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In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of the cerebral cortex in aged male Wistar rats (65 and 91 weeks old) were affected by low-dose X-ray irradiation (100 cGy or under) compared with those in 7-week-old rats, to elucidate the mechanism of aging inhibition. The following results were obtained: Although radiation sensitivity was observed to decreases with age, low-dose irradiation changed the Mn-SOD activity, lipid peroxide level, and membrane protein fluidity parameter of the cerebral cortex in the aged rats to be closer to those in the youth. These finding suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity.</description><identifier>ISSN: 0891-5849</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/0891-5849(94)90132-5</identifier><identifier>PMID: 8005539</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; Aging - physiology ; Animals ; Biomembrane ; Brain cortex ; Cell Membrane - physiology ; Cell Membrane - radiation effects ; Cerebral Cortex - growth & development ; Cerebral Cortex - radiation effects ; Decrease in lipid peroxide lebel ; Dose-Response Relationship, Radiation ; Free radicals ; Increase in membrane protein fluidity ; Increase in Mn-SOD activity ; Lipid Peroxides - metabolism ; Lipid Peroxides - radiation effects ; Low-dose irradiation ; Male ; Membrane Fluidity - physiology ; Membrane Fluidity - radiation effects ; Rabbits ; Rats ; Rats, Wistar ; Superoxide Dismutase - metabolism ; Superoxide Dismutase - radiation effects ; Thiobarbituric Acid Reactive Substances - analysis ; X-Rays</subject><ispartof>Free radical biology & medicine, 1994-04, Vol.16 (4), p.529-534</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-8400c5690206d32d75e75eaaef4d8393a94f0edc23a9546d7656a932ef92d0063</citedby><cites>FETCH-LOGICAL-c454t-8400c5690206d32d75e75eaaef4d8393a94f0edc23a9546d7656a932ef92d0063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0891-5849(94)90132-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8005539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaoka, Kiyonri</creatorcontrib><creatorcontrib>Edamatsu, Rei</creatorcontrib><creatorcontrib>Itoh, Takehiko</creatorcontrib><creatorcontrib>Akitane, Mori</creatorcontrib><title>Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats</title><title>Free radical biology & medicine</title><addtitle>Free Radic Biol Med</addtitle><description>We previously found that low-dose X-ray irradiation or radon (weak α-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbit. 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These finding suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biomembrane</subject><subject>Brain cortex</subject><subject>Cell Membrane - physiology</subject><subject>Cell Membrane - radiation effects</subject><subject>Cerebral Cortex - growth & development</subject><subject>Cerebral Cortex - radiation effects</subject><subject>Decrease in lipid peroxide lebel</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Free radicals</subject><subject>Increase in membrane protein fluidity</subject><subject>Increase in Mn-SOD activity</subject><subject>Lipid Peroxides - metabolism</subject><subject>Lipid Peroxides - radiation effects</subject><subject>Low-dose irradiation</subject><subject>Male</subject><subject>Membrane Fluidity - physiology</subject><subject>Membrane Fluidity - radiation effects</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Superoxide Dismutase - radiation effects</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>X-Rays</subject><issn>0891-5849</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNtKAzEQhoMotR7eQGGvRC9WJ5vDbm4EEU9QEEHBu5AmsxLpNpps1b69WVt6KQzJhPn_mclHyBGFcwpUXkCjaCkark4VP1NAWVWKLTKmTc1KLpTcJuONZJfspfQOAFywZkRGDYAQTI3J003bou1TEdpiFr5LFxIWr2U0y8LHaJw3vQ_zIsfUhw67aTRzLHx-RpNPG2KPP4PZvKErounTAdlpzSzh4freJy-3N8_X9-Xk8e7h-mpSWi54XzYcwAqpoALpWOVqgTmMwZa7hilmFG8Bna1yJrh0tRTSKFZhqyoHINk-OVn1_Yjhc4Gp151PFmezvGBYJE2lqCnwOgv5SmhjSCliqz-i70xcagp6IKkHTHrApBXXfyS1yLbjdf_FtEO3Ma3R5frlqo75k18eo07W49yi8zET1S74_wf8AotkgWc</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Yamaoka, Kiyonri</creator><creator>Edamatsu, Rei</creator><creator>Itoh, Takehiko</creator><creator>Akitane, Mori</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19940401</creationdate><title>Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats</title><author>Yamaoka, Kiyonri ; Edamatsu, Rei ; Itoh, Takehiko ; Akitane, Mori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-8400c5690206d32d75e75eaaef4d8393a94f0edc23a9546d7656a932ef92d0063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biomembrane</topic><topic>Brain cortex</topic><topic>Cell Membrane - physiology</topic><topic>Cell Membrane - radiation effects</topic><topic>Cerebral Cortex - growth & development</topic><topic>Cerebral Cortex - radiation effects</topic><topic>Decrease in lipid peroxide lebel</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Free radicals</topic><topic>Increase in membrane protein fluidity</topic><topic>Increase in Mn-SOD activity</topic><topic>Lipid Peroxides - metabolism</topic><topic>Lipid Peroxides - radiation effects</topic><topic>Low-dose irradiation</topic><topic>Male</topic><topic>Membrane Fluidity - physiology</topic><topic>Membrane Fluidity - radiation effects</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Superoxide Dismutase - radiation effects</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaoka, Kiyonri</creatorcontrib><creatorcontrib>Edamatsu, Rei</creatorcontrib><creatorcontrib>Itoh, Takehiko</creatorcontrib><creatorcontrib>Akitane, Mori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Free radical biology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaoka, Kiyonri</au><au>Edamatsu, Rei</au><au>Itoh, Takehiko</au><au>Akitane, Mori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats</atitle><jtitle>Free radical biology & medicine</jtitle><addtitle>Free Radic Biol Med</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>16</volume><issue>4</issue><spage>529</spage><epage>534</epage><pages>529-534</pages><issn>0891-5849</issn><eissn>1873-4596</eissn><abstract>We previously found that low-dose X-ray irradiation or radon (weak α-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbit. In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of the cerebral cortex in aged male Wistar rats (65 and 91 weeks old) were affected by low-dose X-ray irradiation (100 cGy or under) compared with those in 7-week-old rats, to elucidate the mechanism of aging inhibition. The following results were obtained: Although radiation sensitivity was observed to decreases with age, low-dose irradiation changed the Mn-SOD activity, lipid peroxide level, and membrane protein fluidity parameter of the cerebral cortex in the aged rats to be closer to those in the youth. These finding suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8005539</pmid><doi>10.1016/0891-5849(94)90132-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Aging Aging - physiology Animals Biomembrane Brain cortex Cell Membrane - physiology Cell Membrane - radiation effects Cerebral Cortex - growth & development Cerebral Cortex - radiation effects Decrease in lipid peroxide lebel Dose-Response Relationship, Radiation Free radicals Increase in membrane protein fluidity Increase in Mn-SOD activity Lipid Peroxides - metabolism Lipid Peroxides - radiation effects Low-dose irradiation Male Membrane Fluidity - physiology Membrane Fluidity - radiation effects Rabbits Rats Rats, Wistar Superoxide Dismutase - metabolism Superoxide Dismutase - radiation effects Thiobarbituric Acid Reactive Substances - analysis X-Rays |
| title | Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats |
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