Metal oxyanion stabilization of the rat glucocorticoid receptor is independent of thiols

The ability of sodium molybdate, both to stabilize the steroid binding activity of glucocorticoid receptors and to prevent the activation of receptor-steroid complexes to a DNA binding species, has long been thought to involve thiols. Two receptor thiols in particular, Cys-656 and Cys-661 of rat rec...

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Veröffentlicht in:	The Journal of biological chemistry 1994-10, Vol.269 (41), p.25621-25628
Hauptverfasser:	Modarress, K J, Cavanaugh, A H, Chakraborti, P K, Simons, S S
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Animals Anions - pharmacology Base Sequence Cyclic GMP - analogs & derivatives Cysteine - genetics Cysteine - metabolism Dexamethasone - analogs & derivatives Dexamethasone - metabolism Methyl Methanesulfonate - analogs & derivatives Methyl Methanesulfonate - pharmacology Molecular Sequence Data Molybdenum - pharmacology Mutation Peptide Fragments - metabolism Rats Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Structure-Activity Relationship Sulfhydryl Compounds - metabolism Trypsin - metabolism Tungsten Compounds - pharmacology Vanadates - pharmacology
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