Activation of human monocytes by the pineal hormone melatonin

To determine the effects of the pineal hormone melatonin on human monocytes, human monocytes were activated by different concentrations of melatonin. Above the activation threshold of 5 x 10(-11) M, melatonin was able to induce the cytotoxicity of human monocytes, the secretion of IL-1, and the prod...

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Veröffentlicht in:	The Journal of immunology (1950) 1994-09, Vol.153 (6), p.2671-2680
Hauptverfasser:	Morrey, KM, McLachlan, JA, Serkin, CD, Bakouche, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Northern Cells, Cultured Cytotoxicity Tests, Immunologic Humans Interleukin-1 - biosynthesis Lipopolysaccharides - pharmacology Macrophage Activation - physiology Melatonin - analysis Melatonin - physiology Monocytes - physiology Nitric Oxide - biosynthesis Pineal Gland - chemistry Protein Kinase C - metabolism Reactive Oxygen Species - metabolism
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