NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling

Although glial cell line-derived neurotrophic factor (GDNF)/Ret signaling is essential for enteric nervous system (ENS) development, the positive regulators regulating GDNF/Ret signaling and controlling ENS development are poorly understood. Here, we show that Nedd4-related E3 ubiquitin ligase-2 (NE...

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Veröffentlicht in:	Cellular signalling 2015-03, Vol.27 (3), p.578-586
Hauptverfasser:	Wei, Rongfei, Qiu, Xiao, Wang, Shaoxia, Li, Yang, Wang, Yiwu, Lu, Kefeng, Fu, Yesheng, Xing, Guichun, He, Fuchu, Zhang, Lingqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enteric nervous system GDNF/Ret signaling Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism Intestines - pathology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mouse NEDL2 Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-ret - metabolism Signal Transduction Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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